Prognostic Value of a Family History of Oral Tongue Squamous Cell Carcinoma: A Matched‐Pair Study

Abstract

Objectives/Hypothesis: To analyze the prognostic value of a family cancer history for predicting survival in patients with oral tongue squamous cell carcinoma (SCC). Study Design: Retrospective case series. Methods: Each patient with a family history was paired with one patient with sporadic oral tongue SCC without a family history. The primary endpoint was disease-specific survival (DSS). Results: In total, 124 patients were enrolled as participants with a family cancer history, and the 5-year DSS rate was 51%. In the matched group, the 5-year DSS rate was 40%. The difference was significant (P = .032). In the smoking patients with a family history, the 5-year DSS rate was 43%. In the smoking patients from the matched group, the 5-year DSS rate was 17%; the difference was significant (P = .028). In nonsmoking patients with a history of cancer, the 5-year DSS rate was 51%; in nonsmoking patients in the matched group, the 5-year DSS rate was 40%; the difference was not significant (P = .141). Conclusions: A family cancer history is associated with improved DSS in surgically treated oral tongue SCC patients.

Significance of SUV Max for Predicting Occult Lymph Node Metastasis and Prognosis in Early-Stage Tongue Squamous Cell Carcinoma

“…is finding was consistent with previous studies [21][22][23]. Poor tumor differentiation was indicated by a higher Ki-67 index, a higher SUV max value, and an enhanced invasion ability of cancer cells [24].…”

Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the Tongue

“…The findings suggesting node positivity on CT or MRI were the following: area with clear evidence of non-fat, lowdensity, or liquid components; largest diameter >15 mm at level II and >10 mm at other levels; and ratio of the longest to smallest diameter ≤2. Drinkers were defined as those who consumed at least one alcoholic drink per day for at least 1 year, and smokers were defined as those who smoked on a daily basis or had quit smoking less than 5 years prior to the study (1,16,17). PNI was considered to be present if tumor cells were identified within the perineural space and/or nerve bundle; LVI was considered positive if tumor cells were noted within the lymphovascular channels (1,11,16,17).…”

“…Drinkers were defined as those who consumed at least one alcoholic drink per day for at least 1 year, and smokers were defined as those who smoked on a daily basis or had quit smoking less than 5 years prior to the study (1,16,17). PNI was considered to be present if tumor cells were identified within the perineural space and/or nerve bundle; LVI was considered positive if tumor cells were noted within the lymphovascular channels (1,11,16,17). Pathological DOI was measured from the level of the adjacent normal mucosa to the deepest point of tumor infiltration regardless of the presence or absence of ulceration (18).…”

Comparison Between Primary and Secondary Pediatric Mucoepidermoid Carcinoma of the Head and Neck

“…Pathologic sections of all included patients were re-reviewed by two head and neck pathologists with at least 10 years of experience who were double-blinded. Perineural invasion (PNI) was considered to be present if tumor cells were identified within the perineural space and/or nerve bundle; lymphovascular invasion (LVI) was positive if a tumor was noted within the lymphovascular channels (15,16). Disease grade was defined according to the World health Organization classification as follows (17): intracystic component <20% (+2), neural invasion (+2), necrosis (+3), ≥4 mitoses/10 high-power field (+3), and anaplasia (+4).…”