Prognostic Value of Albuminuria on Cardiovascular Outcomes After Elective Percutaneous Coronary Intervention

Kunimura, Ayako; Ishii, Hideki; Uetani, Tadayuki; Harada, Ken; Kataoka, Tetsuro; Takeshita, Masahiro; Harada, Kazuhiro; Okumura, Satoshi; Shinoda, Norihiro; Kato, Bunichi; Kato, Masataka; Suzuki, Susumu; Amano, Tetsuya; Murohara, Toyoaki

doi:10.1016/j.amjcard.2015.11.054

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…GFR <60 ml/min/1.73 m2) and CAD is the most frequent cause of cardiovascular death in these patients [8]. Impaired eGFR and the presence of albuminuria associate with occurrence and severity of coronary atherosclerosis and, among patients with CAD, with major adverse cardiovascular outcome [9][10].…”

Section: Introductionmentioning

confidence: 99%

Reduced glomerular filtration rate and prior cardiovascular event entail similar risk for coronary atherosclerotic burden

Piscitelli

Mangiacotti

Marchese

et al. 2019

Preprint

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Background: Prior cardiovascular event and kidney dysfunction are both strong risk factor for coronary artery disease. Aim of this study is to assess coronary atherosclerotic burden in a large population of patients undergoing coronary angiography, according to the prior cardiovascular event or chronic kidney disease. Methods: We evaluated 700 consecutive patients who underwent CA. Serum creatinine to estimate glomerular filtration rate (eGFR) was measured. Clinically significant CAD was defined by the presence of a coronary lesion resulting in a luminal stenosis >50%. For the purpose of the study, the whole population was divided into 4 subgroups according to the presence/absence of eGFR <60 ml/min/1.73 m2 or prior cardiovascular event: eGFR≥60/no event (Group A), eGFR≥60/yes event (Group B), eGFR<60/no event (Group C), eGFR<60/yes event (Group D). Results: As expected, patients in group D had the worst clinical and biochemical profile. These patients also showed the highest values of ACR (p<0.001) and the lowest values of eGFR (p<0.01). One-hundred-ninety-six patients had three vessel disease. Considering group A as reference, the risk of having three-vessel disease was increased in group B (OR= 2.09; 95% CI 1.37-3.19), in group C, (OR= 1.80; 95% CI 1.04-3.14) and finally in group D (OR= 3.35; 95% CI 2.01-5.58). The risk carried by group C was not significantly different from that carried by Group B: OR= 0.86; 95% CI 0.5-1.5. Conclusions: In our study low eGFR seems to have the same excess risk of prior CV event.

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Section: Introductionmentioning

confidence: 99%

Reduced glomerular filtration rate and prior cardiovascular event entail similar risk for coronary atherosclerotic burden

Piscitelli

Mangiacotti

Marchese

et al. 2019

Preprint

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show abstract

“…Besides eGFR, albuminuria which is the abnormal level of protein in the urine has an important prognostic value and should be included in the evaluation of patients with CKD [ 10 , 11 ]. Albuminuria is the marker of renal injury which has link with kidney disease progression, increased atherosclerosis, and left ventricular abnormalities indirectly contributing to cardiovascular diseases/disorders and death [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Impaired glomerular filtration rate, high grade albuminuria and associated factors among adult patients admitted to tertiary Hospital in Ethiopia

2018

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BackgroundChronic Kidney Disease (CKD), the worldwide Public Health problem, is also one of the rising non-communicable diseases in low and middle-income countries. Its early detection and treatment using readily available, inexpensive therapies can slow or prevent progression to end-stage renal disease. Hence, this study was aimed at assessing impaired estimated glomerular filtration rate (eGFR), high grade albuminuria, and associated factors among adult patients admitted to Jimma University Medical Center in South west Ethiopia.MethodsHospital based cross sectional study was conducted from November 1, 2016 to April 30, 2017. Consecutive sampling method was used to select study participants. Logistic regression analysis was conducted to generate factors associated with impaired estimated GFR and albuminuria. A P-value of < 0.05 was considered statistically significant.ResultsThe study involved 422 patients admitted to Jimma University Medical Center who had at least one test result for urinalysis and serum creatinine level during the study period. Fifty two (12.3%) of the study subjects had high grade albuminuria, 19.2, 19.4, and 32.7% had impaired estimated glomerular filtration rate according to Modification of Diet in Renal Disease (MDRD-4), Chronic Kidney Disease Epidemiology (CKD-EPI), and Cockcroft-Gault (CG) equations respectively. Old age (AOR = 2.4;95%CI:1.4–4.01), male sex (AOR = 2.1;95%CI:1.16–3.7), and hypertension (AOR = 2.23; 95%CI:1.24–4.01) were independently associated with impaired eGFR using one of the two equations while diabetes mellitus (AOR = 2.8; 95%CI:1.33–5.82) and BP measurement above optimal (AOR = 4.7; 95%CI:1.9–11.53) were associated with high grade albuminuria.ConclusionsHigh grade albuminuria and impaired eGFR were found in significant proportion of adults admitted to the hospital for various medical conditions. Old age, hypertension, diabetes mellitus and male gender were independently associated with these alterations. These findings necessitate routine urinalysis and estimation of GFR for all hospitalized adults with known CKD risk factors.

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“…1 ). 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 Five studies were conducted on myocardial infarction. 26 , 27 , 28 , 30 , 31 While one was on ACS, 32 the other was on patients who received elective percutaneous coronary intervention (PCI).…”

Section: Resultsmentioning

confidence: 99%

Microalbuminuria and mortality in individuals with coronary heart disease: A meta-analysis of a prospective study

Govardi

Yulianda

Habib

et al. 2023

Indian Heart Journal

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Prognostic Value of Albuminuria on Cardiovascular Outcomes After Elective Percutaneous Coronary Intervention

Cited by 9 publications

References 22 publications

Reduced glomerular filtration rate and prior cardiovascular event entail similar risk for coronary atherosclerotic burden

Reduced glomerular filtration rate and prior cardiovascular event entail similar risk for coronary atherosclerotic burden

Impaired glomerular filtration rate, high grade albuminuria and associated factors among adult patients admitted to tertiary Hospital in Ethiopia

Microalbuminuria and mortality in individuals with coronary heart disease: A meta-analysis of a prospective study

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