Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer

Li, Wentao; Tse, Lap Ah; Au, Joseph Siu-Kie; Yu, Kai; Wang, Feng; Yu, Ignatius Tak-sun

doi:10.1186/s40880-017-0188-5

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…No association was found between vegetable and fruit consumption examined before diagnosis and overall mortality in lung cancer patients ( 48 , 49 ). However, a high cruciferous vegetable intake before diagnosis was linked to a lower site-specific cancer mortality (HR: 0.69; 95% CI: 0.49, 0.95) in female lung cancer patients from the Shanghai Women's Health Study ( 43 ).…”

Section: Resultsmentioning

confidence: 86%

“…The main cause for this classification was the concern of changes in exposure status among patients. In addition, minor reasons reducing the quality of studies were observed: bias due to confounding ( 40 , 41 , 57 ), bias in classification of exposures ( 39 , 40 , 42 , 47 , 48 , 56 ), and bias in selection of the reported results ( 36 , 39 , 41 , 42 , 57 , 61 ) ( Supplemental Table 7 ). More details about the items considered in both the ROBINS-E and the STROBE-nut scale are provided as supplementary material ( Supplemental Tables 8 and 9 , respectively).…”

Section: Resultsmentioning

confidence: 99%

“…Vegetable and fruit consumption may be inversely related to the incidence of lung cancer ( 66 , 67 ), particularly in smoker populations ( 65 , 68 ). Although an uncertain relation was found between lung cancer prognosis and total vegetable and fruit intake ( 48 , 49 ), Wu et al ( 43 ) reported a 31% lower site-specific cancer mortality in female nonsmoker lung cancer patients consuming ∼120 g of cruciferous vegetables per day. Similarly, the risk of lung cancer incidence was lower among high consumers of cruciferous vegetables ( 68 ).…”

Section: Discussionmentioning

confidence: 99%

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Vegetable and Fruit Consumption and Prognosis Among Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies

Hurtado-Barroso

Trius-Soler

Lamuela‐Raventós

et al. 2020

Advances in Nutrition

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The number of cancer survivors is growing rapidly worldwide, especially long-term survivors. Although a healthy diet with a high vegetable and fruit consumption is a key factor in primary cancer prevention, there is a lack of specific dietary recommendations for cancer survivors, except in the case of breast cancer [World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) report]. We have therefore carried out a systematic review and meta-analysis of cohort studies reporting on the associations between vegetable and fruit intake with cancer recurrence and mortality and all-cause mortality in cancer patients. After a comprehensive search of PubMed and Scopus databases, the results of 28 selected articles were analyzed. A high vegetable intake before diagnosis was inversely associated with overall mortality in survivors of head and neck (HR: 0.75; 95% CI: 0.65, 0.87) and ovarian cancer (HR: 0.78; 95% CI: 0.66, 0.91). In ovarian cancer patients, prediagnosis fruit intake was also inversely associated with all-cause mortality (HR: 0.82; 95% CI: 0.70, 0.96). The evidence was insufficient for survivors of other cancers, although these associations generally tended to be protective. Therefore, more studies are needed to clarify the association between vegetable and fruit consumption and the prognosis of these different types of cancer. To date, the general recommendation to consume ≥5 servings of vegetables and fruit per day (∼400 g/d) could underestimate the needs of cancer survivors, particularly those with ovarian tumors, in which the recommendation could increase to ∼600 g/d (i.e., 300 g/d of vegetables and 300 g/d of fruit).

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Section: Resultsmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Vegetable and Fruit Consumption and Prognosis Among Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies

Hurtado-Barroso

Trius-Soler

Lamuela‐Raventós

et al. 2020

Advances in Nutrition

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“…Worldwide interest in MR has greatly increased over the last 10 years; this method uses genome-wide association study (GWAS) data to demonstrate the exact causal relationship between A and B (using instrumental variable analysis with genetic instruments), which can avoid the influences of other exposure factors on the outcomes (12). Previously, several observational studies have shown that appropriate alcohol consumption (amount per day and frequency per week) could prevent lung cancer (13,14). Among these studies, the study by Brenner et al (13) demonstrated that alcohol intake of less than 20 g/d was a beneficial factor for the prevention of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Among these studies, the study by Brenner et al (13) demonstrated that alcohol intake of less than 20 g/d was a beneficial factor for the prevention of lung cancer. Moreover, Li et al (14) indicated that occasionally consuming alcohol throughout the week was a favorable factor for the survival of Chinese men with lung cancer. Therefore, we conducted an MR study to confirm the causal relationship between the habitual consumption of alcohol with meals and lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study

Chen¹,

Hu²,

Wang³

et al. 2021

Ann Transl Med

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Background: The objective of this study was to determine the causal relationship between habitual alcohol consumption with meals and lung cancer.Methods: Public genetic summary data from two large consortia [the Neale Lab and the International Lung Cancer Consortium (ILCCO)] were used for analysis. As the instrumental variables of habitual alcohol consumption with meals, data on genetic variants were retrieved from Neale Lab. Additionally, genetic data from other consortia [Global Lipid Genetics Consortium (GLGC), Tobacco, Alcohol and Genetics (TAG), Genetic Investigation of Anthropocentric Traits (GIANT)] were utilized to determine whether alcohol could causally alter some general risk factors for lung cancer. The primary outcome was the risk of lung cancer (11,348 cases and 15,861 controls in the ILCCO). The R package TwoSampleMR was used for analysis.Results: Based on the inverse variance weighted method, the results of the two-sample Mendelian randomization (MR) analyses indicated that commonly consuming alcohol with meals was a protective factor, reducing lung cancer risk [odds ratio (OR) 0.175, 95% confidence interval (CI): 0.045-0.682, P=0.012].The heterogeneity analysis revealed that the causal relationship analyses of different types of lung cancer all had low heterogeneity (P>0.05). The horizontal pleiotropic study showed that major bias was unlikely.The MR assumptions did not seem to be violated. The causal relationship analyses between habitual alcohol consumption with meals and some risk factors for cancers showed that this alcohol consumption habit was a beneficial factor for reducing body mass index (BMI) and the number of cigarettes smoked per day.Conclusions: Habitual appropriate alcohol consumption with meals is a protective factor for the development of lung cancer.

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Survival and prognostic factors of early‐stage non‐small cell lung cancer in Central and Eastern Europe: A prospective cohort study

et al. 2023

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Background Although early diagnosis and surgical resection of the tumor have been shown to be the most important predictors of lung cancer survival, long‐term survival for surgically‐resected early‐stage lung cancer remains poor. Aims In this prospective study we aimed to investigate the survival and prognostic factors of surgically‐resected early‐stage non‐small cell lung cancer (NSCLC) in Central and Eastern Europe. Methods We recruited 2052 patients with stage I‐IIIA NSCLC from 9 centers in Russia, Poland, Serbia, Czech Republic, and Romania, between 2007–2016 and followed them annually through 2020. Results During follow‐up, there were 1121 deaths (including 730 cancer‐specific deaths). Median survival time was 4.9 years, and the 5‐year overall survival was 49.5%. In the multivariable model, mortality was increased among older individuals (HR for each 10‐year increase: 1.31 [95% CI: 1.21–1.42]), males (HR:1.24 [1.04–1.49]), participants with significant weight loss (HR:1.25 [1.03–1.52]), current smokers (HR:1.30 [1.04–1.62]), alcohol drinkers (HR:1.22 [1.03–1.44]), and those with higher stage tumors (HR stage IIIA vs. I: 5.54 [4.10 – 7.48]). However, education, chronic obstructive pulmonary diseases (COPD), and tumor histology were not associated with risk of death. All baseline indicators of smoking and alcohol drinking showed a dose‐dependent association with the risk of cancer‐specific mortality. This included pack‐years of cigarettes smoked (p‐trend = 0.04), quantity of smoking (p‐trend = 0.008), years of smoking (p‐trend = 0.010), gram‐days of alcohol drank (p‐trend = 0.002), frequency of drinking (p‐trend = 0.006), and years of drinking (p‐trend = 0.016). Conclusion This study shows that the 5‐year survival rate of surgically‐resected stage I‐IIIA NSCLC is still around 50% in Central and Eastern Europe. In addition to non‐modifiable prognostic factors, lifetime patterns of smoking and alcohol drinking affected the risk of death and disease progression in a dose‐dependent manner in this population.

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Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer

Cited by 6 publications

References 32 publications

Vegetable and Fruit Consumption and Prognosis Among Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies

Vegetable and Fruit Consumption and Prognosis Among Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies

Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study

Survival and prognostic factors of early‐stage non‐small cell lung cancer in Central and Eastern Europe: A prospective cohort study

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