Prognostic Value of Atrial Fibrillation Inducibility in Patients Without History of Clinical Atrial Fibrillation

Marquardt, Jonathan; Marquardt, Kira; Scheckenbach, Christian; Zhang, Wenzhong; Stimpfle, Fabian; Duckheim, Martin; Maleck, Carole; Seizer, Peter; Gawaz, Meinrad; Schreieck, Jürgen; Gramlich, Michael

doi:10.4022/jafib.1837

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…In 52 patients without prior tachyarrhythmia, NI ( N = 19) was associated with reduced arrhythmia occurrence for up to 2.5 years after the induction attempt. After three years, however, AF onset rate no longer differed between patient groups [ 23 ]. In larger study populations, AF inducibility was a poor prognostic biomarker for AF recurrence after ablative therapy [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

AF Inducibility Is Related to Conduction Abnormalities at Bachmann’s Bundle

Staveren

Does

Heida

et al. 2021

JCM

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We investigated whether patterns of activation at Bachmann’s bundle are related to AF inducibility. Epicardial mapping of Bachmann’s bundle during sinus rhythm was performed prior to cardiac surgery (192 electrodes, interelectrode distances: 2 mm). Compared to non-inducible patients (N = 20), patients with inducible AF (N = 34) had longer lines of conduction block (18(2–164) mm vs. 6(2–28) mm, p = 0.048), prolonged total activation time (55(28–143) ms vs. 46(24–73) ms, p = 0.012), multiple wavefronts entering Bachmann’s bundle more frequently (64% vs. 37%, p = 0.046) and more often areas of simultaneous activation (conduction velocity > 1.7 m/s, 45% vs. 16%, p = 0.038). These observations further support a relation between conduction abnormalities at Bachmann’s bundle and AF inducibility. The next step is to examine whether Bachmann’s bundle activation patterns can also be used to identify patients who will develop AF after cardiac surgery during both short- and long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

AF Inducibility Is Related to Conduction Abnormalities at Bachmann’s Bundle

Staveren

Does

Heida

et al. 2021

JCM

View full text Add to dashboard Cite

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Incidentally Induced Atrial Fibrillation During Programmed Electrical Stimulation in Patients With Depressed Left Ventricular Systolic Function After an Acute Myocardial Infarction

Sakthivel,

Risum,

Bundgaard

et al. 2024

Noninvasive Electrocardiol

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BackgroundThe aim of this study was to investigate the clinical implication of incidentally induced atrial fibrillation (AF) during programmed electrical stimulation (PES) in patients with left ventricular systolic dysfunction (≤40%) after an acute myocardial infarction (MI).MethodsIn this study, we included 231 patients from the Cardiac Arrhythmias and RIsk Stratification after Myocardial InfArction (CARISMA) study with left ventricular ejection fraction ≤40% and no prior history of AF. These patients underwent PES 6 weeks post‐MI as part of the study protocol. Patients all received an implantable cardiac monitor (ICM) 3–21 days post‐MI and were continuously monitored for cardiac arrhythmias for 2 years. Induction of AF was unwanted but reported if this incidentally occurred.ResultsA total of 61 patients (26%) developed AF within 2 years of follow‐up, in which n = 10 (29%) had incidental AF during PES at baseline. The overall risk of AF was not significantly increased in patients with incidental AF (n = 34) during PES compared to patients without incidental AF (n = 197) (HR 1.6 [0.9–3.0], p = 0.14). The risk of bradyarrhythmia (HR = 0.2 [0.0–1.2], p = 0.07), ventricular arrhythmias (HR = 0.7 [0.1–5.8], p = 0.77), and major cardiovascular events (MACE) (HR 0.5 [0.2–1.7], p = 0.28) was not significantly different in patients with versus without incidental AF.ConclusionsIncidentally induced AF during PES in post‐MI patients with reduced LVEF was not significantly associated with a higher risk of long‐term atrial fibrillation, other cardiac arrhythmias, or major cardiac events.Trial RegistrationNCT00145119

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Prognostic Value of Atrial Fibrillation Inducibility in Patients Without History of Clinical Atrial Fibrillation

Cited by 2 publications

References 20 publications

AF Inducibility Is Related to Conduction Abnormalities at Bachmann’s Bundle

AF Inducibility Is Related to Conduction Abnormalities at Bachmann’s Bundle

Incidentally Induced Atrial Fibrillation During Programmed Electrical Stimulation in Patients With Depressed Left Ventricular Systolic Function After an Acute Myocardial Infarction

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