Prognostic value of automated SPECT scoring system for coronary artery disease in stress myocardial perfusion and fatty acid metabolism imaging

Abstract

Quantitative SPECT analysis contributes to the diagnostic and prognostic assessment of coronary artery disease. A novel automated scoring system (heart score view) can provide identical quantitative information to that determined by expert visual analysis. The aim of the present study is to evaluate the prognostic value of the automated SPECT scoring system when applied to stress thallium and resting beta-methyl-iodophenyl pentadecanoic acid (BMIPP) SPECT images. After a preliminary validation of the automated system by comparison with expert visual analyses, outcome data from 151 consecutive patients with suspected or known coronary artery disease without prior myocardial infarction were analyzed using automated SPECT scores on stress thallium and resting BMIPP images. The software quantified abnormalities as summed stress (SSS), summed rest and summed difference scores for stress thallium and as summed BMIPP scores (SBS). Cardiac events occurred over a period of 48 months in 29 (19.2 %) patients with diabetes mellitus, a lower left ventricular ejection fraction (LVEF) and more abnormal scores for thallium and BMIPP. Multivariate predictors of all cardiac events included diabetes mellitus and thallium SSS. The global Chi-square value was significantly increased when SSS was added to the clinical information (diabetes mellitus and LVEF). Negative predictive values of thallium SSS and SBS were almost identical at 84 % for all cardiac events and 98 % for hard cardiac events. Automatically quantified perfusion and BMIPP scores are related to cardiac events and these values can improve the risk stratification of coronary patients particularly when stress thallium imaging is combined with clinical information.

Diagnostic utility of 123I-BMIPP imaging in patients with Takotsubo cardiomyopathy

“…Such discordant 123 I-BMIPP uptake was observed more often in areas of acute rather than chronic myocardial infarction (59% at <4 weeks versus 31% at >4 weeks after onset), and more often in areas supplied by revascularized arteries than in areas supplied by non-revascularized arteries (74% versus 28%). A recent study showed that the perfusion-metabolism information could improve the risk stratification of the patients with coronary artery disease [20].…”

Validation of Automated Quantification of Myocardial Perfusion Single-Photon Emission Computed Tomography Using Heart Score View in Patients With Known or Suspected Coronary Artery Disease

“…[7][8][9] It is applicable to any type of myocardial SPECT imaging using a standard Windows computer. In addition, HSV has another advantage that SPECT data can be analyzed in any institution because HSV is a free software package not requiring a dedicated computer.…”

“…In addition, HSV has another advantage that SPECT data can be analyzed in any institution because HSV is a free software package not requiring a dedicated computer. Several studies have reported the usefulness of HSV in detecting coronary artery disease 7,8) or assessing risk stratification, 9) but its scoring performance remains to be investigated. In the current study, we showed that SSS and SRS were significantly higher on HSV than visual analysis or QPS mainly due to different scoring results in the basal area.…”

“…[4][5][6] Recently, a new software package called Heart Score View (HSV; version 1.5) (Nihon Medi-Physics, Japan) was developed in Japan. [7][8][9] In the current study, we compared the scoring results of myocardial perfusion among visual analysis, QPS and HSV in patients with known or suspected coronary artery disease.…”

Risk factors of non-sustained ventricular tachycardia by technetium-perfusion imaging in patients with coronary artery lesions caused by Kawasaki disease

“…MPI has been performed in patients with coronary artery disease, and myocardial ischemia, perfusion defects, and low left ventricular function. Further, singlephoton emission computed tomography (SPECT) score such as summed stress score in MPI predicts cardiac events and the prognosis of the patient with coronary artery diseases, and they have become major determinants for risk stratification of future cardiac events [5][6][7]. We investigated the factors related to the occurrence of NSVT in patients with CAL after KD using MPI.…”