Prognostic value of breast cancer cytologic grading: A retrospective study of 213 cases

Ciatto, Stefano; Bonardi, R; Herd-Smith, Andrea; Cariaggi, Paola; Confortini, Massimo; Bulgaresi, Paolo

doi:10.1002/dc.2840090210

Cited by 24 publications

(17 citation statements)

References 6 publications

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“…[18][19][20][21][22][23][24][25][26] FNA cytologic studies have developed a number of scoring systems, with results similar to those obtained from histologic sections. 1,[4][5][6][7][8][9]12,13 Here the grading system developed by Robinson 2 for cytologic samples was contrasted with histologic grading. Other studies carried out with various cytologic grading systems 1,4-14 have obtained similar results, thus confirming the value of FNA cytology for predicting the histologic grade of a certain tumor preoperatively and therefore its eventual biologic behavior.…”

Section: Discussionmentioning

confidence: 99%

Robinson Cytologic Grading of Invasive Ductal Breast Carcinoma

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Robinson Cytologic Grading of Invasive Ductal Breast Carcinoma

et al. 2005

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“…This might be particularly true for NCB unless multiple samples are taken. Studies [24][25][26][27][28][29][30][31][32] and thus the assessment of prognostic factors on preoperative samples might not be as unreliable as believed previously.…”

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confidence: 99%

Preoperative assessment of prognostic factors in breast cancer

Denley

2001

Journal of Clinical Pathology

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The adoption of preoperative diagnostic strategies involving fine needle aspiration cytology (FNAC) or core biopsy is well established, allowing the planning of operating lists and bed occupancy and patient involvement in therapeutic management. In addition to diagnosis, however, pathologists are increasingly being asked to provide pathological prognostic information from preoperative samples. This leader describes techniques for predicting prognosis and response to treatment on these specimens and some of the problems inherent in the determination of prognosis on small samples. For example, although histological grade can be assessed relatively reliably on either core or FNAC samples, the evaluation of tumour type (which includes an overall assessment of the architecture of a given tumour) may be less reliable on small preoperative samples. Other well recognised histological prognostic factors, such as vascular channel invasion or tumour size, cannot be determined accurately on small preoperative samples. For those patients who might benefit from neoadjuvant treatment, predicting the response to such treatments-for example, by the assessment of oestrogen receptor status-can readily be performed on either core biopsy or FNAC. In the future, other molecular markers such as C-erbB-2 might also prove beneficial in predicting response to newly developed treatments. (J Clin Pathol 2001;54:20-24)

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“…Considerable limitation of FNA is to differentiate between intraductal and invasive carcinoma, as a diagnosis of intraductal neoplasia requires the careful study of overall architecture and basement membrane integrity that only histopathology can provide. [32][33][34][35] …”

Section: Significance Of Cytological Gradingmentioning

confidence: 99%

Grading systems in the cytological diagnosis of breast cancer: A review

et al. 2014

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In developing countries, diagnosis of breast carcinoma is still made on fine-needle aspiration cytology (FNAC). For the resource-poor settings, FNAC is cheaper, less invasive and can sample different areas of the lesion compared with core needle biopsy. The role of breast FNA is usually limited to just categorize the lesion as benign or malignant. Prognostic information from cytomorphology, conveyed to the clinician depends upon the cytopathologist's way of formatting the report. PubMed-based literature search collated the information from articles describing the architectural and cytological features studied on breast aspiration smears. This review focuses on cytomorphological features and the different grading systems with their strengths, short-comings, and practical applicability. Eight worldwide articles proposing new methods of grading the cytological smears from breast cancers were published between 1980 and 2006. All the grading methods were developed for the most common type of breast cancer, that is, infiltrating duct carcinoma (not otherwise specified) type, and most of the workers used Papanicolaou-stained smears for the purpose of grading. Moreover, if interpreted carefully FNAC smears can convey information on most of the histological features. Hence, in developing countries, the focus should be on extracting the maximum information from cytological smears, so that a more precise "surgical pathology" type diagnosis can be given, instead of merely reporting as benign or malignant. Among all the discussed grading systems, we suggest grading system by Howell would be most appropriate and closest to the accepted histologic grading system as it applies Scarff-Bloom-Richardson histological grading system with modifications on FNA smears. We recommend it to be followed by all cytopathologists, in order to bring uniformity in the reporting of breast FNAs for grading the malignant lesions.

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Prognostic value of breast cancer cytologic grading: A retrospective study of 213 cases

Cited by 24 publications

References 6 publications

Robinson Cytologic Grading of Invasive Ductal Breast Carcinoma

Robinson Cytologic Grading of Invasive Ductal Breast Carcinoma

Preoperative assessment of prognostic factors in breast cancer

Grading systems in the cytological diagnosis of breast cancer: A review

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