Prognostic value of cardiac troponin-I levels following catheter-based coronary interventions

Fuchs, Shmuel; Kornowski, Ran; Mehran, Roxana; Lansky, Alexandra J.; Satler, Lowell F.; Pichard, Augusto D.; Kent, Kenneth M.; Clark, Chester E.; Stone, Gregg W.; Leon, Martin B.

doi:10.1016/s0002-9149(00)00699-8

Cited by 120 publications

(70 citation statements)

References 19 publications

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“…Cardiac-specific troponins are a more sensitive assay that has become the gold standard for the detection of necrosis, and plays a pivotal role in risk factor assessment in subjects with ACS. Elevation of troponin is common following PCI, occurring in one-third or more of subjects (1,16). A rise in troponin is associated with impairment of microvascular perfusion (3) and necrosis documented by cardiac magnetic resonance imaging (4).…”

Section: Discussionmentioning

confidence: 99%

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Hubáček

Basran

Shrive

et al. 2009

Canadian Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Hubáček

Basran

Shrive

et al. 2009

Canadian Journal of Cardiology

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“…4 It has been found that the higher the concentration of myocardial troponin on admission for acute coronary artery syndrome the higher the incidence of myocardial infarction and death, so the myocardial troponin concentration is used in the evaluation of acute coronary artery syndrome patients for establishing the treatment strategies and evaluating prognosis. [23][24][25] Nicorandil is a compound of a nicotinamide derivative and nitrate moiety, which works like a nitrate drugs and at the same time opens ATP-sensitive K + channels. similar to the nitrate drugs it increases blood flow in the coronary artery and decreases both preload and afterload.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Protective Effects of Nicorandil During Percutaneous Coronary Intervention in Patients With Unstable Angina

Kim

Jeong

Yun

et al. 2005

Circ J

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“…The prevalence of periprocedural myocardial infarction is 7.3% to 17.9% defined by CK-MB isoenzyme elevation > 3x upper limit of normal (ULN) and 15.0% to 44.2% defined by cardiac troponin > ULN [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] . The results of several studies suggested that any elevation in CK-MB was associated with reduced long-term survival and that there was a direct correlation between the magnitude of myonecrosis and mortality.…”

Section: Mortality?mentioning

confidence: 99%

“…Other studies have shown that only large myocardial infarctions were predictive of a poor long-term outcome [40][41][42][43][44][45][46] . Similarly, some studies showed that the serum concentration of cardiac troponin was an independent predictor of survival, others did not [47][48][49][50][51][52][53][54][55] . However two recent meta-analyses concluded that an elevated cardiac troponin levels after PCI does provide prognostic information [56,57] .…”

Section: Mortality?mentioning

confidence: 99%

Myocardial ischemia is a key factor in the management of stable coronary artery disease

Iwasaki¹

2014

WJC

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Previous studies demonstrated that coronary revascularization, especially percutaneous coronary intervention (PCI), does not significantly decrease the incidence of cardiac death or myocardial infarction in patients with stable coronary artery disease. Many studies using myocardial perfusion imaging (MPI) showed that, for patients with moderate to severe ischemia, revascularization is the preferred therapy for survival benefit, whereas for patients with no to mild ischemia, medical therapy is the main choice, and revascularization is associated with increased mortality. There is some evidence that revascularization in patients with no or mild ischemia is likely to result in worsened ischemia, which is associated with increased mortality. Studies using fractional flow reserve (FFR) demonstrate that ischemia-guided PCI is superior to angiography-guided PCI, and the presence of ischemia is the key to decisionmaking for PCI. Complementary use of noninvasive MPI and invasive FFR would be important to compensate for each method's limitations. Recent studies of appropriateness criteria showed that, although PCI in the acute setting and coronary bypass surgery are properly performed in most patients, PCI in the non-acute setting is often inappropriate, and stress testing to identify myocardial ischemia is performed in less than half of patients. Also, some studies suggested that revascularization in an inappropriate setting is not associated with improved prognosis. Taken together, the presence and the extent of myocardial ischemia is a key factor in the management of patients with stable coronary artery disease, and coronary revascularization in the absence of myocardial ischemia is associated with worsened prognosis.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Coronary artery bypass surgery; Coronary revascularization; Fractional flow reserve; Myocardial ischemia; Myocardial perfusion imaging; Percutaneous coronary intervention Core tip: Studies of myocardial perfusion imaging demonstrate that, for patients with moderate to severe ischemia, revascularization is the preferred therapy for survival benefit. For patients with no to mild ischemia, medical therapy is the main choice, and revascularization is associated with increased mortality probably because of worsened ischemia. Studies using fractional flow reserve demonstrate that ischemia-guided percutaneous coronary intervention (PCI) is superior to angiography-guided PCI, and the presence of ischemia is the key factor in decision-making for PCI. Thus, myocardial ischemia is a key factor in the management of patients with stable coronary artery disease.Iwasaki K. Myocardial ischemia is a key factor in the management of stable coronary artery disease. World J Cardiol

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Prognostic value of cardiac troponin-I levels following catheter-based coronary interventions

Cited by 120 publications

References 19 publications

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Myocardial Protective Effects of Nicorandil During Percutaneous Coronary Intervention in Patients With Unstable Angina

Myocardial ischemia is a key factor in the management of stable coronary artery disease

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