Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy

Wang, Lin; Zhai, Zhiwei; Ji, Dengbo; Li, Zhongwu; Gu, Jin

doi:10.1007/s00384-015-2226-6

Cited by 16 publications

(16 citation statements)

References 52 publications

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“…There were fifteen studies assessing CD45RO and survival in rectal, colon or colorectal cancer, one of which had an overlapping cohort [61], leaving 14 independent studies comprising 4235 patients [54,60,69,84,93,98,109,111,[117][118][119]122,127,131]. Twelve studies found CD45RO to be associated with better survival, but only eleven (3992 patients) of these were independent [54,60,69,98,109,[117][118][119]122,127,131]. In rectal cancer, there were two studies (263 patients) assessing CD45RO, both finding it to be significantly associated with survival: one of which performed a manual assessment of CD45RO in pre-treatment biopsies [69], the other an electronic assessment in post-resection specimens [131].…”

Section: Cd45ro (Effector Memory T-cells)mentioning

confidence: 99%

“…Twelve studies found CD45RO to be associated with better survival, but only eleven (3992 patients) of these were independent [54,60,69,98,109,[117][118][119]122,127,131]. In rectal cancer, there were two studies (263 patients) assessing CD45RO, both finding it to be significantly associated with survival: one of which performed a manual assessment of CD45RO in pre-treatment biopsies [69], the other an electronic assessment in post-resection specimens [131]. Neither study compared CD45RO in more than one tumour region.…”

Section: Cd45ro (Effector Memory T-cells)mentioning

confidence: 99%

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The local inflammatory response in colorectal cancer – Type, location or density? A systematic review and meta-analysis

Alexander

McMillan

Park

2020

Cancer Treatment Reviews

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The host anti-tumour inflammatory response is a strong prognostic indicator, and tumour infiltrating lymphocytes (TILs) are believed to have a complimentary role alongside TNM assessment in dictating future management. However, there is wide disagreement regarding the most efficacious and cost-effective method of assessment. Methods: A comprehensive literature search was performed of EMBASE, MedLine and PubMed as well as an assessment of references to identify all relevant studies relating to the assessment of the peri-tumoural inflammatory response or TILs and prognosis in colorectal cancer (CRC). A meta-analysis was performed of 67 studies meeting the REMARK criteria using RevMan software. Results: Intratumoural assessment of both CD3 and CD8 in CRC were significant for disease-free survival (DFS) (combined HRs 0.46; 95%CI: 0.39-0.54 and 0.54; 95%CI: 0.45-0.65), as well as overall survival (OS) and disease-specific survival (DSS). The same was true for assessment of CD3 and CD8 at the invasive margin (DFS: combined HRs 0.45; 95%CI: 0.33-0.61 and 0.51; 95%CI: 0.41-0.62). However, similar fixed effects summaries were also observed for H&E-based methods, like Klintrup-Makinen grade (DFS: HR 0.62; 95%CI: 0.43-0.88). Furthermore, inflammatory assessments were independent of MSI status. Conclusion: The evidence suggests that it is the density of a coordinated local inflammatory infiltrate that confers survival benefit, rather than any individual immune cell subtype. Furthermore, the location of individual cells within the tumour microenvironment does not appear to influence survival. The authors advocate a standardised assessment of the local inflammatory response, but caution against emphasizing the importance of any individual immune cell subtype.

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Section: Cd45ro (Effector Memory T-cells)mentioning

confidence: 99%

Section: Cd45ro (Effector Memory T-cells)mentioning

confidence: 99%

The local inflammatory response in colorectal cancer – Type, location or density? A systematic review and meta-analysis

Alexander

McMillan

Park

2020

Cancer Treatment Reviews

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“…Our previous work demonstrated that CD45RO expression significantly correlates with prognosis of LARC patients with neoadjuvant radiotherapy (39). To determine if prognostic associations existed between the expression of PD-L1, PD-1, CD8, and patient survival, Kaplan-Meier survival curves were plotted.…”

Section: 000 Spearman Test) No Correlation Was Found Between Pd-1mentioning

confidence: 99%

Somatic Mutations and Immune Alternation in Rectal Cancer Following Neoadjuvant Chemoradiotherapy

Zhang

et al. 2018

Cancer Immunology Research

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Checkpoint blockade therapy triggers tumor-specific immune responses in a variety of cancer types. We presumed that rectal cancer patients could have become sensitive to immunotherapy after receiving neoadjuvant chemoradiotherapy (nCRT). In this study, we report immune alternation in post-nCRT patients compared with pretreatment conditions from gene-expression omnibus (GEO) data. Whole-exome sequencing of 14 locally advanced rectal cancer (LARC) patient samples showed that nCRT induced new mutations compared with the paired pretreatment biopsies, evidenced by appearance of a neoantigen landscape. An association was identified between mutation burden and enrichment of immune activation-related pathways. Animal experiment results further demonstrated that radiotherapy enhanced the efficacy of anti-PD-1. Mutation burden and the neoantigens of LARC patients were associated with response to nCRT. The mRNA expression profiling of 66 pretreatment biopsy samples from LARC patients showed that immune activation-related pathways were enriched in response to nCRT. PD-L1 expression was negatively correlated with disease-free survival in the CD8low expression patient group who received nCRT in a cohort of 296 samples. Thus, nCRT was able to alter immune function in LARC patients, which may be associated with the appearance of neoantigens. Neoantigens could make rectal cancer patients potential candidates to receive checkpoint blockade immunotherapy, and mutation burden could be a useful biomarker to stratify patients into responding and nonresponding groups for immunotherapy.

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“…These studies indicate the anti-tumor effect of CD45RO + T cells. In addition, CD45RO + TILs are negatively correlated with tumor size, lymph nodes metastasis in breast cancer patients (27), associated with lesser advanced T stage and TNM stage in rectal cancer (28), and correlated with well differentiation and lower TNM stage in renal cell carcinoma (29). Consistent with previous studies, we found that CD45RO expression was increased in lung adenocarcinoma tissues compared to paired adjacent lung tissues, and CD45RO + TILs were negatively correlated with tumor size, lymph node metastasis and TNM stage in lung adenocarcinoma patients.…”

Section: Analysis Of Baseline Factors Affecting Osmentioning

confidence: 99%

“…Consistent with previous studies, we found that CD45RO expression was increased in lung adenocarcinoma tissues compared to paired adjacent lung tissues, and CD45RO + TILs were negatively correlated with tumor size, lymph node metastasis and TNM stage in lung adenocarcinoma patients. These findings might result from the effect of CD45RO + TILs on inhibiting the proliferation and migration of tumor cells through multiple mechanisms, such as excreting various cytokines, activating shrewd (28,31).…”

Section: Analysis Of Baseline Factors Affecting Osmentioning

confidence: 99%

Tumor-infiltrating CD45RO+ memory cells correlate with favorable prognosis in patients with lung adenocarcinoma

Zhong

2018

J. Thorac. Dis.

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Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy

Abstract: The density of CD45RO(+) TILs cannot only predict tumor downstaging and ypTNM stage for rectal cancer following 30 Gy/10 f nRT but also promisingly predict long-term outcomes. These findings may be used to stratify patients and make alternative strategy of adjuvant treatment.

Cited by 16 publications

References 52 publications

The local inflammatory response in colorectal cancer – Type, location or density? A systematic review and meta-analysis

The local inflammatory response in colorectal cancer – Type, location or density? A systematic review and meta-analysis

Somatic Mutations and Immune Alternation in Rectal Cancer Following Neoadjuvant Chemoradiotherapy

Tumor-infiltrating CD45RO+ memory cells correlate with favorable prognosis in patients with lung adenocarcinoma

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