Prognostic value of chloride channel accessory mRNA expression in colon cancer

Xiao-hang, Pan; Wang, Qiao-Qi; Xu, Chen; Yan, Ling; Pang, Sen; Gan, Jialiang

doi:10.3892/ol.2019.10615

“…The clinical data from 438 patients with CRC was used in the analysis. Table 1 lists the correlations between clinical characteristics and OS in the patients with CRC [ 16 ]. The results showed that TNM stage was related with OS.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer

Jiang

¹

,

Xiao-hang

²

,

Yan

³

et al. 2021

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Background Colorectal cancer (CRC) is a deadly form of cancer worldwide. Heat shock protein 70 ( Hsp70 ) belongs to the family of human HSPs and plays an essential role in multiple cellular developments and in responding to environmental changes. However, studies on the relationship between CRC and the Hsp70 family are rare. Material/Methods Data pertaining to 438 patients with CRC was downloaded from The Cancer Genome Atlas database. To investigate the prognostic significance of the Hsp70 genes, survival and joint-effect analyses were conducted. The correlation between prognosis-related Hsp70 genes and clinical factors in CRC was analyzed using a nomogram. Gene set enrichment analysis (GSEA) was performed to explore the complex enrichment pathway in CRC with the prognosis-related Hsp70 genes. Results According to multivariate Cox regression survival analysis, low expression levels of HSPA1A , HSPA1B , and HSPA1L were correlated with improved overall survival (OS). According to the joint-effects survival analysis, the joint low expression levels of HSPA1A , HSPA1B , and HSPA1L were related to improved OS. The 1-, 3-, 5-, and 10-year survival rates of patients with CRC were predicted by constructing a nomogram model based on HSPA1A , HSPA1B , HSPA1L , and tumor stage. The GSEA results indicated the biological roles of HSPA1A , HSPA1B , and HSPA1L in CRC. Conclusions Low expression levels of HSPA1A , HSPA1B , and HSPA1L were strongly correlated with improved prognosis in CRC and might serve as latent prognostic biomarkers in CRC.

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“…The detailed clinical data attained from the TCGA concerning the 438 CRC patients are presented. Correlations between the clinical data and OS in the CRC patients are illustrated in Table 1 [ 17 ]. TNM stage had a significant association with OS (P<0.001; Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Prognostic Value of Enolase Gene Family in Colon Cancer

Xiao-hang

¹

,

Wu

²

,

Chen

³

et al. 2020

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Background Colorectal cancer (CRC), the most common gastrointestinal cancer, is associated with high mortality rates. Enolase is a major enzyme present in the glycolytic pathway. However, the functional significance of the enolase (ENO) gene family in the pathogenesis of CRC has been unclear. Material/Methods The data associated with 438 CRC patients from The Cancer Genome Atlas database were extracted for analysis. Survival analyses with Cox regression was performed to construct a prognostic signature. We investigated the processes that underlies the correlation between ENO genes and overall survival (OS) using gene set enrichment analysis (GSEA). We then developed a connectivity map to identify candidate target drugs for CRC. Results The multivariate survival analysis showed that low expression of ENO2 and ENO3 had a significant correlation with longer OS. The joint-effects survival analysis indicated that the combined low expression of ENO2 and ENO3 was highly correlated with favorable OS. As indicated by the gene set enrichment analysis (GSEA), the ENO gene is involved in various biological pathways and has multiple roles. Potential pharmacological targets of ENO2 and ENO3 were constructed as well. Conclusions Low expression levels of both ENO2 and ENO3 were linked to a positive prognosis for CRC. Both ENO2 and ENO3 show promise as prognostic biomarkers for colon cancer patients.

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“…CXCL13 showed significantly lower expression in CRC, and patients with CXCL13 deletion had a significantly higher risk of relapse [60]. CLCA1 was also reported to be involved in the pathophysiology of CRC, and upregulation of CLCA1 was associated with a favorable prognosis [61,62].…”

Section: Discussionmentioning

confidence: 99%

Identification of Hub Genes Related to Carcinogenesis and Prognosis in Colorectal Cancer Based on Integrated Bioinformatics

Gong

¹

,

Kao

²

,

Zhang

³

et al. 2020

Mediators of Inflammation

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The high mortality of colorectal cancer (CRC) patients and the limitations of conventional tumor-node-metastasis (TNM) stage emphasized the necessity of exploring hub genes closely related to carcinogenesis and prognosis in CRC. The study is aimed at identifying hub genes associated with carcinogenesis and prognosis for CRC. We identified and validated 212 differentially expressed genes (DEGs) from six Gene Expression Omnibus (GEO) datasets and the Cancer Genome Atlas (TCGA) database. We investigated functional enrichment analysis for DEGs. The protein-protein interaction (PPI) network was constructed, and hub modules and genes in CRC carcinogenesis were extracted. A prognostic signature was developed and validated based on Cox proportional hazards regression analysis. The DEGs mainly regulated biological processes covering response to stimulus, metabolic process, and affected molecular functions containing protein binding and catalytic activity. The DEGs played important roles in CRC-related pathways involving in preneoplastic lesions, carcinogenesis, metastasis, and poor prognosis. Hub genes closely related to CRC carcinogenesis were extracted including six genes in model 1 (CXCL1, CXCL3, CXCL8, CXCL11, NMU, and PPBP) and two genes and Metallothioneins (MTs) in model 2 (SLC26A3 and SLC30A10). Among them, CXCL8 was also related to prognosis. An eight-gene signature was proposed comprising AMH, WBSCR28, SFTA2, MYH2, POU4F1, SIX4, PGPEP1L, and PAX5. The study identified hub genes in CRC carcinogenesis and proposed an eight-gene signature with good reproducibility and robustness at the molecular level for CRC, which might provide directive significance for treatment selection and survival prediction.

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Prognostic value of chloride channel accessory mRNA expression in colon cancer

Cited by 10 publications

References 37 publications

Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer

Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer

Prognostic Value of Enolase Gene Family in Colon Cancer

Identification of Hub Genes Related to Carcinogenesis and Prognosis in Colorectal Cancer Based on Integrated Bioinformatics

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