Prognostic Value of Coronary Artery Stenoses, Markis Class, and Ectasia Ratio in Patients with Coronary Artery Ectasia

Abstract

Objectives: To assess the prognostic value of coexisting coronary artery disease (CAD), Markis class, and ectasia ratio for major adverse cardiovascular events in patients with coronary artery ectasia (CAE). Methods: A total of512consecutive patients with angiographically proven CAE were enrolled. Coronary ectasia extent was graded using the Markis class, and ectasia severity was assessed based on the ectasia ratio. Patients were followed up for a median of 34.6 months. Results: In the current study, 76 cases had isolated CAE, while the remaining 436 cases had coexisting CAD (mixture CAE). Males (84.4%) were predominantly affected, and the right coronary artery (55.1%) was most commonly involved. During follow-up, 86 overall major adverse cardiovascular events were diagnosed. Kaplan-Meier analysis failed to reveal any differences between isolated and mixture CAE in both cumulative and event-free survival analyses (p = 0.429 and p = 0.277, respectively). Moreover, when patients were divided into 4 groups according to Markis class (type I-IV) or 2 groups based on the ectasia ratio (1.5-2.0 and >2.0), there was no significant difference in survival outcomes among the groups (p > 0.05). Conclusions: In this follow-up study with a relatively large sample, the survival rate of patients with CAE appeared to be independent of coexisting CAD and ectasia extent and severity.

Prognostic significance, angiographic characteristics and impact of antithrombotic and anticoagulant therapy on outcomes in high versus low grade coronary artery ectasia: A long‐term follow‐up study

“…Similar to prior studies, we found that the RCA was most commonly affected by ectasia followed by the LAD and the circumflex (Table ). We found an almost equal distribution of the four Markis types in our cohort.…”

“…We had a nearly equal distribution of isolated CAE (46%) and CAE with CAD (54%). Most prior studies have reported a much lower prevalence of isolated CAE and this is also likely related to geographic variations or study inclusion criterion (in case of CASS registry). Most studies have not reported on the prevalence of sluggish flow.…”

“…To our knowledge, only one prior study has assessed the relationship of the grade of CAE with clinical outcomes. Zhang et al studied 512 CAE patients (76 with isolated CAE and rest with CAE + CAD) in a Chinese population. Each patient was graded according to the Markis classification and mean follow‐up was 34.6 months.…”

“…We found an almost equal distribution of the four Markis types in our cohort. This distribution has varied depending on the study and a geographic variation has been suggested 14,24 . We had a nearly equal distribution of isolated CAE (46%) and CAE with CAD (54%).…”

Клинический Случай Гигантской Аневризмы Правой Коронарной Артерии

“…Логично предположить, что, как и у больных с фибрилляцией предсердий, усиление антитромботической терапии за счет добавления второго антиагреганта не приведет к существенному снижению риска тромбозов АКА. Полагают [4,22,23], что препаратами выбора при данной патологии могут быть антикоагулянты, опыт использования которых, к сожалению, ограничивается относительно небольшими наблюдательными исследованиями и регистрами. Одно из наиболее показательных исследований [17] включало 1698 больных с инфарктом миокарда, подвергнутых ангиографии с последующим инвазивным лечением.…”