Prognostic Value of D-Dimer/Fibrinogen Ratio in the Adverse Outcomes of Patients Hospitalized for Heart Failure

Abstract

Aim: To evaluate the clinical value of plasma D-dimer/fibrinogen ratio (DFR) in patients hospitalized for heart failure (HF). Methods: Clinical data of 235 patients were retrospectively analyzed. Kaplan–Meier method and Cox regression analysis were used to identify significant prognosticators. Results: The Kaplan–Meier analysis showed that a higher DFR level was significantly associated with an increase in the end point outcomes, including HF readmission, thrombotic events and death (log-rank test: p < 0.001). The multivariate Cox regression analysis showed that the high tertile of DFR was significantly associated with the study end points (HR: 2.18; 95% CI: 1.31–3.62; p = 0.003), compared with the low tertile. Conclusion: DFR is a reliable prognostic indicator for patients hospitalized for HF.

Prognostic Value of D-Dimer/Fibrinogen Ratio on In-Hospital Outcomes of Patients With Heart Failure and Covid-19

“…Some studies have evaluated the value of plasma D-dimer/fibrinogen ratio (DFR) in the diagnosis of pulmonary thromboembolism and lower extremity venous thrombosis [ 20–22 ]. DFR also shows a unique value in determining the pathophysiological mechanism of stroke [ 23 ] and can predict the prognosis of gastrointestinal stromal tumors in patients hospitalized with HF [ 24 ]; however, the prognostic values of DFR in patients with COVID-19 with a history of HF is unclear. Therefore, the present study was designed to evaluate the relationship between DFR and in-hospital prognosis for patients with COVID-19 with a history of HF.…”

Multi‐variable biomarker approach in identifying incident heart failure in chronic kidney disease: results from the Chronic Renal Insufficiency Cohort study

“…27,28 This early inflammatory/haemostasis dysfunction marker in combination with BNP, fibrinogen, and hsTnT may help identify patients with CKD at the highest risk of developing incident HF. 27,28 The utility of an incident HF risk stratification with a simple biomarker score was previously shown by Agarwal et al 29 in the ARIC study and was further advanced in the CKD population by Bansal et al 12 in the CRIC cohort. However, the inclusion of FGF23 is a unique feature of the current study as part of a multi-variable biomarker panel.…”

“…While fibrinogen has been a known key factor in blood coagulation and link to coronary artery disease and thrombosis, 26 recent literature has linked fibrinogen to HF to inflammation and haemostatic dysfunction. Fibrinogen has been linked to adverse outcomes in HF and risk of HF readmission 27,28 . This early inflammatory/haemostasis dysfunction marker in combination with BNP, fibrinogen, and hsTnT may help identify patients with CKD at the highest risk of developing incident HF 27,28 …”

Combined Assessment of D-Dimer with the Get with the Guidelines—Heart Failure Risk Score and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Acute Decompensated Heart Failure with Preserved and Reduced Ejection Fraction

“…Recently, Zhao et al demonstrated the predictive power of the plasma D-dimer/fibrinogen ratio in patients hospitalized for HF [32]. Further investigation is needed to evaluate the combination of D-dimer with other biomarkers.…”