Prognostic value of echocardiographic evaluation of cardiac mechanics in patients with aortic stenosis and preserved left ventricular ejection fraction

Faganello, Giorgio; Pagura, Linda; Collia, Dario; Barbati, Giulia; Paldino, Alessia; Ferro, Matteo Dal; Croatto, Elisa; Sinagra, Gianfranco; Pedrizzetti, Gianni; Lenarda, Andrea Di

doi:10.1007/s10554-022-02756-z

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…For the first time, we evaluated left ventricular systolic function in patients with repaired CoA using an approach that evaluated both left ventricular strain values and HDF parameters, where the latter were considered a new imaging marker of LV function 13,14,37 . It was recently demonstrated that the finding of reduced LVLF values in patients with severe aortic stenosis was associated with aortic valve replacement surgery and reduced follow‐up survival 16 and that overall HDF improved immediately after transcatheter aortic valve implantation. In contrast, GLS values remained unchanged 38 .…”

Section: Discussionmentioning

confidence: 99%

“…Novel echocardiographic techniques such as speckle tracking (ST) and the study of the longitudinal (base‐apex oriented) LV hemodynamic force (HDFs) represent new promising parameters of LV function 11–14 . We recently suggested a novel approach that considers LV strain values and hemodynamic forces (HDFs) parameters in patients with preserved LV systolic function 15,16 . In this study, we first evaluated the impact of HDF changes in cardiac risk stratification in patients with previously successfully repaired CoA and preserved LVEF.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14] We recently suggested a novel approach that considers LV strain values and hemodynamic forces (HDFs) parameters in patients with preserved LV systolic function. 15,16 In this study, we first evaluated the impact of HDF changes in cardiac risk stratification in patients with previously successfully repaired CoA and preserved LVEF.…”

Section: Introductionmentioning

confidence: 99%

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Impact of left ventricular hemodynamic forces in adult patients with treated aortic coarctation and preserved left ventricular systolic function

Faganello,

Collia,

Pagura

et al. 2024

Echocardiography

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BackgroundThe LV myocardial strain and hemodynamic forces (HDFs) are innovative markers of LV function. Aortic coarctation is safely repaired in infancy; however, mortality and morbidity remain increased in later life. The study investigated the role of left ventricular myocardial deformation and HDFs in asymptomatic patients who underwent successful aortic coarctation repair.MethodsClinical and echocardiographic data were analyzed from 42 repaired CoA, 32 ± 20 years after surgery, 2D echocardiographic global longitudinal strain (GLS), circumferential strain (GCS) and HDFs were determined. CoA patients were compared with 42 patients affected by blood hypertension and 84 healthy controls; all matched for age and gender.ResultsAll groups had normal LV ejection fraction (LVEF), dimensions, and volumes. CoA patients showed a significantly higher rate of LV mass indexed (p < .001) and left atrial volumes indexed (p < .001). LV myocardial and endocardial global longitudinal and circumferential strain were decreased in CoA patients (p < .001, p < .001; p = .032 and p < .001, respectively). HDF parameters such as LV longitudinal force, LV systolic longitudinal force and LV impulse (LVim) were uniformly reduced (p = .006, p = .001, and p = .001, respectively). LV myocardial strain and HDF parameter values were independently associated with hospitalization for heart failure on univariable Cox regression analysis.ConclusionDespite preserved LVEF, patients with CoA had lower LV myocardial strain and HDF parameters values, independently associated with hospitalization for heart failure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of left ventricular hemodynamic forces in adult patients with treated aortic coarctation and preserved left ventricular systolic function

Faganello,

Collia,

Pagura

et al. 2024

Echocardiography

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Editor’s choice to the March 2023 issue

Reiber

2023

Int J Cardiovasc Imaging

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Assessing cardiac mechanics through left ventricular haemodynamic forces

Aimo,

Panichella,

Fabiani

et al. 2024

European Heart Journal - Imaging Methods and Practice

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Hemodynamic forces (HDFs), which represent the forces exchanged between blood and surrounding tissues, are critical in regulating the structure and function of the left ventricle (LV). These forces can be assessed on cardiac magnetic resonance or transthoracic echocardiography exams using specialized software, offering a non-invasive alternative for measuring intraventricular pressure gradients. The analysis of HDFs can be a valuable tool in improving our understanding of cardiovascular disease and providing insights beyond traditional diagnostic and therapeutic approaches. For instance, HDF analysis has the potential to identify early signs of adverse remodeling and cardiac dysfunction, which may not be detected by standard imaging methods such as bidimensional or speckle-tracking echocardiography. This review aims to summarize the principles of HDF analysis and to reappraise its possible applications to cardiac disorders.

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Prognostic value of echocardiographic evaluation of cardiac mechanics in patients with aortic stenosis and preserved left ventricular ejection fraction

Cited by 4 publications

References 36 publications

Impact of left ventricular hemodynamic forces in adult patients with treated aortic coarctation and preserved left ventricular systolic function

Impact of left ventricular hemodynamic forces in adult patients with treated aortic coarctation and preserved left ventricular systolic function

Editor’s choice to the March 2023 issue

Assessing cardiac mechanics through left ventricular haemodynamic forces

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