Prognostic value of FDG‐PET volumetric parameters in patients with p16‐positive oropharyngeal squamous cell carcinoma who received curative resection followed by postoperative radiotherapy or chemoradiotherapy

Abstract

Patients with p16-positive disease with high metabolic tumor burden were associated with higher distant metastasis rates, translating into worse survival. These patients may not be optimal candidates for treatment deintensification. © 2016 Wiley Periodicals, Inc. Head Neck 38: First-1524, 2016.

Metabolic tumor volume and total lesion glycolysis as prognostic factors in head and neck cancer: Systematic review and meta‐analysis

“…Most of the studies suggest these factors have a good prognostic value, as this MAA has also shown. In contrast, lymph nodes measurements do not seem to have an independent value, 25,37,38 although they may have a role in HPV positive patients 39‐41 . Despite their good prognostic potential, none of these parameters are being considered in the traditional staging methods (TNM) nor in treatment decision making, thereby prospective studies are scarce and no general cut‐off values have been established yet.…”

“…In contrast, lymph nodes measurements do not seem to have an independent value, 25,37,38 although they may have a role in HPV positive patients. [39][40][41] Despite their good prognostic potential, none of these parameters 42 performed a prospective study of 63 patients with laryngeal cancer and high MTV, comparing their survival according to the treatment strategy selected for each case-surgery-based vs radiation-based. Their results suggest a better survival rate for the patients treated with a surgery-based therapy, pointing to the possibility of MTV being able to help decide between treatments.…”

Visceral adipose tissue volume and CT‐attenuation as prognostic factors in patients with head and neck cancer

“…For continuous variables, the maximally selected chi‐square method was used to classify variables into 2 groups. In the multivariate analyses of the adipose tissue parameters, five different models with 7 different covariates including age, sex, BMI, TNM stage, serum C‐reactive protein (CRP) level, and maximum SUV and TLG of primary tumor, which are known to be associated with survival in head and neck cancer, were reconstructed. The significance of the association between adipose tissue parameters and survival (disease progression‐free survival and distant failure‐free survival) was assessed after adjusting for these seven covariates.…”

Pretreatment metabolic tumor volume as a prognostic factor in HPV‐associated oropharyngeal cancer in the context of AJCC 8th edition staging

“…[26][27][28][29] This study provides some support to the use of MTV as a prognostic marker in patients treated with surgery as well as definitive radiotherapy. The data available regarding the value of MTV in patients treated with definitive surgery are more limited, but there is evidence that MTV is a prognostic marker for p16 positive oropharyngeal cancers treated with resection followed by radiotherapy.…”

“…The data available regarding the value of MTV in patients treated with definitive surgery are more limited, but there is evidence that MTV is a prognostic marker for p16 positive oropharyngeal cancers treated with resection followed by radiotherapy. [26][27][28][29] This study provides some support to the use of MTV as a prognostic marker in patients treated with surgery as well as definitive radiotherapy. Although MTV does not reach statistical significance as a prognostic factor when postoperatively treated patients are considered alone, there is separation of the survival curves.…”