Prognostic value of ferroptosis‐related genes in patients with lung adenocarcinoma

Abstract

Background The prevalence of lung adenocarcinomas (LUADs) has dramatically increased in recent decades. Ferroptosis is a process of iron‐dependent regulatory cell death. It is still unclear whether the expression of ferroptosis‐related genes (FRGs) is involved in the pathogenesis and survival of patients with LUAD. Methods We retrieved LUAD data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and used LASSO Cox regression analysis to select the gene signature suitable for modeling. The risk score was calculated according to the model, and the patients were divided into high‐ and low‐risk groups according to the median risk score. Functional enrichment analysis was carried out by this group, and a model for predicting clinical prognosis was established by combining this group with clinical factors. Results Gene set enrichment analysis (GSEA) and single‐sample gene set enrichment analysis (ssGSEA) analysis showed that there were several immune‐related pathways and immune infiltration differences between high‐ and low‐risk groups. A prognostic model integrating 10 ferroptosis‐related genes (FR‐DEGs), and clinical factors were constructed and validated in an external cohort. Conclusions The FR‐DEGs signature was related to immune infiltration, and a model based on FR‐DEGs and clinical factors was established to predict the prognosis of patients with LUAD.

Identification of a Ferroptosis-Related Signature Model Including mRNAs and lncRNAs for Predicting Prognosis and Immune Activity in Hepatocellular Carcinoma

“…Besides, results from both difference in APC co-stimulation and co-inhibition appears contradictory in the immune microenvironment. However, we found the results are somewhat similar to the researches about ferroptosis-related signature in other cancers (6,(89)(90)(91). Though the mechanisms illustrating tumor susceptibility to ferroptosis have been an intense area of research in past decades, the complex relationship between tumor immunity and ferroptosis remains elusive.…”

Construction of a Ferroptosis-Related Long Non-coding RNA Prognostic Signature and Competing Endogenous RNA Network in Lung Adenocarcinoma

“…FANCD2, a nuclear protein that responds to DNA damage repair, negatively regulated ferroptosis of bone marrow injury in cancer treatment and could be a potential target of anticancer therapies ( Song et al, 2016 ). In addition, a 10 ferroptosis-related genes signature and a ferroptosis-related gene signature with five genes were constructed to predict the prognosis of patients with LUAD ( Wang S. et al, 2021 ; Zhu et al, 2021 ). In general, ferroptosis-related genes play important roles in the progression of LUAD.…”

Identification of an Autophagy-Related lncRNA Prognostic Signature and Related Tumor Immunity Research in Lung Adenocarcinoma

“…For example, Duan et al 18 constructed a prognostic signature based on ARGs, which served as a novel biomarker in LUAD. Meanwhile, Zhu et al 21 identi ed a ferroptosis-related gene signature and explored the immune cells in ltration. In this study, several ARlncRNAs included in the modeling process have been already reported in various malignant tumors, such as CARD8-AS1 22 23 , AC060780.1 24 , AC123595.1 25 26 , UGDH-AS1 27 , LINC00996 28 , LINC00861 29 30 31 , AL606489.1 17 , HLA-DQB1-AS1 32 , LINC00654 33 LINC00847 34 35 .…”