Prognostic value of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: a meta-analysis

Yan, Chen-Hua; Xie, Yanyou; Hua, Yaqi; Li, Sihui; Fu, Hang; cheng, zhiqiang; Wu, Jiang

doi:10.1007/s12094-023-03271-w

Cited by 1 publication

(2 citation statements)

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“…There was no significant difference in PFS, which suggested that the results may be influenced by the different cutoff values. Different from the previous two published meta-analyzes (31,32), our study provides more evidence and information on the role of GNRI in predicting PFS in HMs.…”

Section: Discussionmentioning

confidence: 63%

“…However, only seven articles were included. In the results analyzing the relationship between GNRI and PFS, only 2 and 3 studies were included, respectively, which would lead to inaccurate results ( 31 , 32 ). To date, we found that other five new studies ( 27 , 29 , 33 – 36 ) also explored the relationship between GNRI and survival outcomes in patients with HMs.…”

Section: Introductionmentioning

confidence: 99%

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Geriatric nutritional risk index as a predictor of prognosis in hematologic malignancies: a systematic review and meta-analysis

Yu,

Tian,

et al. 2023

Front. Nutr.

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ObjectiveRecent studies have reported inconsistent results regarding the association between geriatric nutritional risk index (GNRI) and clinical outcomes in patients with hematologic malignancies (HMs). We performed a meta-analysis to evaluate the effect of low GNRI on the overall survival (OS) and progression-free survival (PFS) in patients with HMs.Research Methods and ProceduresWe conducted the research via PubMed, Embase, and Cochrane Library databases to identify trials. Exploring the association between GNRI and prognosis in patients with HMs. A meta-analysis of OS and PFS was performed. Quality In Prognostic Studies instrument and Newcastle–Ottawa quality assessment Scale were used to assess the quality of included trials.ResultsFourteen studies enrolling 3,524 patients with HMs were included. Low GNRI was associated with shorter OS (Hazard ratio (HR) = 1.77; 95% CI = 1.44–2.18, p < 0.01) and PFS (HR = 1.63; 95% CI = 1.17–2.27, p < 0.01) in patients with HMs. In the subgroup analysis, GNRI was not significantly associated with prognosis in Chinese patients with HMs (OS, HR =1.33; 95% CI = 0.89–1.98, p = 0.16; PFS, HR = 1.70; 95% CI = 0.72–4.01, p = 0.23). For the subgroup with a GNRI cutoff value less than 98, there was no significant difference in PFS (HR = 1.34; 95% CI = 0.98–1.83, p = 0.06).ConclusionLow GNRI negatively impacted on the prognosis in patients with HMs. Prospective studies to identify the best cut-off value for GNRI are required.

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Section: Discussionmentioning

confidence: 63%