Prognostic value of hepatic dysfunction in dengue infection

Bagepally, Ravi Shankar; Rao, G.R. Srinivas; Reddy, Bibas; Kumar, B. Vijay; Reddy, B. Vamshi Krishna; Reddy, S. Jithender; Raut, Sikanta Kumar; Gowri, T.J. Sri; Reddy, Sugunakar

doi:10.1016/j.jceh.2013.03.208

Cited by 2 publications

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“…Bagepally RS et al, in their study of 105 patients, found the significant difference in the degree of elevation in the liver enzymes in the survived (n=93) and non-survived group (n=12). Mean value of ALT was 260U/L (survived group) and 931U/L (mortality group), while the mean value of AST was 390U/L (survived group) and 1075U/L (mortality group) [15] . Similar findings were seen in our study, though the degree of elevation of AST and ALT in the non-survived group was far higher as seen in table 4.…”

Section: Discussionmentioning

confidence: 90%

“…Liver damage has been found to be more common among females in the large study from Brazil by de Souza LJ et al (74.6% of females vs 52.2% of males) [9] . However, studies by Soni A et al [12] and Bagepally RS et al [15] showed male preponderance (M:F ratio 2:1 and 2.5:1 respectively). Our study also showed slight overall male preponderance (M:F ratio 1.1:1) while the male to female ratio in patients with hepatic dysfunction was 2.8:1.…”

Section: Discussionmentioning

confidence: 90%

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Study of Hepatic Dysfunction in Dengue Fever: Does it Tell You the Prognosis?

Kamath

Ahmed

2021

ijirms

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Introduction: Dengue is the most rapidly spreading mosquito-borne viral disease. Liver is the most commonly affected organ and manifests as asymptomatic transaminitis to acute liver failure. Aim: (1) To study the clinical and biochemical profile of liver involvement. (2) To find the association between severity of hepatic dysfunction, morbidity and mortality in the admitted patients. Method and Material: This was a prospective study involving confirmed dengue fever cases admitted in Tata Main Hospital from January 2018 to December 2019. Cases were classified into non-severe dengue and severe dengue based on 2009 WHO classification. Severity of hepatic dysfunction was divided into grades A, B, C and D and correlation with various outcomes which included length of stay, complications and mortality was studied through relevant investigations. Results: Out of the 175 cases, Non-severe Dengue (NSD) was seen among 72.6% patients while severe dengue (SD) in 28.5% patients. Normal liver function was found in 68.6%, Grade B liver injury in 8% while Grade C and Grade D liver injury in 16.6% and 16.8% patients respectively. Mean AST levels were found to be higher than those of ALT levels. Longer hospital stay, complications like shock, acute kidney injury (AKI), thrombocytopenia and mortality were significantly more in patients with higher grades of liver dysfunction (p=0.03), while ARDS and MODS were seen only in patients with Grade C and Grade D liver injury. Conclusion: AST and ALT levels were statistically higher in Dengue fever patients with worse outcome. They can thus, serve as prognostic markers of severe Dengue.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Study of Hepatic Dysfunction in Dengue Fever: Does it Tell You the Prognosis?

Kamath

Ahmed

2021

ijirms

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“…20 Bagepally RS et, stated that aminotransferases were elevated in majority of patients. 16 The main differences between survived (n=93) and mortality (n=12) group were as follows; mean value of SGPT was 260IU/mL (survived) and 931IU/mL (mortality group), and mean value of SGOT was 390IU/mL (survived) and 1075IU/mL (mortality group). 16 17 These observations on proportion of patients who required platelet transfusion and duration of hospital stay were similar to the findings of the present study.…”

Section: Discussionmentioning

confidence: 94%

“…Out of 105 patients, males were 74 (70%). 16 Mukherjee S et al, study revealed that majority of the cases was in the age group of 15-30 years, (69.5%) and the mean age was 27 years. Out of 82 patients 63 (77%) were males and 19 (23%) were females.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of hepatocellular dysfunction and its association with severity in dengue patients

Dutta

Kumar

et al. 2019

Int J Adv Med

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Background: Dengue is a mosquito-borne infection that in recent years has become an important disease of international public health concern. Dengue virus infections and illness when symptomatic, that patients tend to present with a significantly wide variety manifestations. The aim of the study was to evaluate liver dysfunction in patients with dengue infections.Methods: The present study was undertaken as an observational cross-sectional study the period June 2017 to December 2018. The details of all patients with serologically proved dengue fever admitted in the hospital were reviewed. Data including routine blood count, liver function test (LFT), prothrombin time (PT), activated partial prothrombin time (APTT), abdominal ultrasonography was studied. Statistical analysis: Data was analyzed using SPSS version 21.0. Difference between proportions was tested by using chi square test. Pearson correlation coefficient was used to measure linear correlation between two continuous variables. A p value <0.05 was consideredstatistically significant.Results: Majority of the study participants were in the age group of 16-30 years (57.5%) and were males (64.5%). Fever, Headache and joint pain were the most common symptoms noted among the study participants. Majority of the study participants were found to have elevated levels of SGOT (75.3%), SGPT (64.2%) levels and lower levels ofserum albumin (68.6%) on evaluation. Statistically significant association was observed between elevated liver enzymes and presence of features of dengue haemorrhagic fever.Conclusions: Considerably high proportion of patients with dengue infection were found to have hepatic dysfunction in the form of deranged liver enzymes.

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Prognostic value of hepatic dysfunction in dengue infection

Cited by 2 publications

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Study of Hepatic Dysfunction in Dengue Fever: Does it Tell You the Prognosis?

Study of Hepatic Dysfunction in Dengue Fever: Does it Tell You the Prognosis?

Evaluation of hepatocellular dysfunction and its association with severity in dengue patients

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