Prognostic Value of High-Dose Dobutamine Stress Magnetic Resonance Imaging in 1,493 Consecutive Patients

Korosoglou, Grigorios; Elhmidi, Yacine; Steen, Henning; Schellberg, Dieter; Riedle, Nina; Ahrens, Johannes; Lehrke, Stephanie; Merten, Constanze; Loßnitzer, Dirk; Radeleff, Jannis; Zugck, Christian; Giannitsis, Evangelos; Katus, Hugo A.

doi:10.1016/j.jacc.2010.06.020

Cited by 114 publications

(62 citation statements)

References 27 publications

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“…[20][21][22][23]26,30 Of the 13 series of patients included for subanalysis using the criterion to define the test as negative, 7 used the absence of inducible PDs [20][21][22]27,[29][30][31] as the criterion to define a negative test; of these studies, 1 used dipyridamole as the stressor, 4 used adenosine, and 2 used a stress protocol with both dipyridamole and adenosine. In the remaining 6 series of patients, the definition of a negative study was based on the absence of inducible ; of these, 1 used dipyridamole and 5 used dobutamine as the stressor.…”

Section: Resultsmentioning

confidence: 99%

“…Data from 1 study were not considered for subanalysis because information related to PDs and WMAs could not be separated. 26 In this study, dobutamine was used as the stressor. Eight of the 14 included studies reported rates of myocardial revascularization and UA in addition to major coronary events.…”

Section: Resultsmentioning

confidence: 99%

“…20,[26][27][28][29][30] Figure 4 shows the forest plot of the NPV and ERNT for each study, as well as the pooled estimates yielded by the random-effect model (I 2 =94.7%; P<0.001). The individual NPVs ranged from 75.27% to 100%.…”

Section: Predictive Value Of Stress Cmr For Myocardial Revascularizatmentioning

confidence: 99%

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The Prognostic Value of Normal Stress Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease

Gargiulo

Dellegrottaglie

Bruzzese

et al. 2013

Circ: Cardiovascular Imaging

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Background— Ischemia detection with stress cardiac magnetic resonance (CMR) is typically based on induction of either myocardial perfusion defect or wall motion abnormality. Single-center studies have shown the high value of stress CMR for risk stratification. The aim of this study was to define the prognostic value of stress CMR for prediction of adverse cardiac events in patients with known or suspected coronary artery disease. Methods and Results— Studies published between January 1985 and April 2012 were identified by database search. We included studies using stress CMR to evaluate subjects with known or suspected coronary artery disease and providing primary data on clinical outcomes of nonfatal myocardial infarction or cardiac death with a follow-up time ≥3 months. Total of 14 studies were finally included, recruiting 12 178 patients. The negative predictive value for nonfatal myocardial infarction and cardiac death of normal CMR was 98.12% (95% confidence interval, 97.26–98.83) during a weighted mean follow-up of 25.3 months, resulting in estimated event rate after a negative test equal to 1.88% (95% confidence interval, 1.17–2.74). The corresponding annualized event rate after a negative test was 1.03%. Comparable negative predictive values for major coronary events were obtained in studies considering the absence of inducible perfusion defect compared with those evaluating the absence of inducible wall motion abnormality (98.39% versus 97.31%, respectively; P =0.227 by meta-regression analysis). Conclusions— Stress CMR has a high negative predictive value for adverse cardiac events, and the absence of inducible perfusion defect or wall motion abnormality shows a similar ability to identify low-risk patients with known or suspected coronary artery disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Prognostic Value of Normal Stress Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease

Gargiulo

Dellegrottaglie

Bruzzese

et al. 2013

Circ: Cardiovascular Imaging

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“…Существует независимая связь между неблагопри-ятными сердечно-сосудистыми исходами при много-факторном анализе у пациентов с положительным результатом МРТ сердца с добутамином и бессобы-тийной выживаемостью >99% у пациентов без при-знаков ишемии на протяжении 36-месячного пери-ода наблюдения [200]. Имеются подобные данные по перфузионной МРТ сердца с аденозиновой нагруз-кой [201].…”

Section: стресс-мрт сердцаunclassified

2013 Esc Guidelines on the Management of Stable Coronary Artery Disease

Montalescot

Sechtem²,

Achenbach³

et al. 2014

Russ J Cardiol

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“…In a direct comparison, 3.0 T MPI-MR was found to be superior to 1.5 T MPI-MR for the detection of FFR-positive lesions [44]. In 1493 patients with known or suspected CAD, a negative dobutamine stress MR was associated with a <0.5 % 4-year event rate in patients with a low or intermediate pre-test probability of CAD [45]. However, the 4-year event rate in patients with a negative dobutamine stress MR but a high pre-test probability or with known CAD was still 5 % [45].…”

Section: Comparison With Ffrmentioning

confidence: 94%

CT fractional flow reserve: the next level in non-invasive cardiac imaging

2012

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The haemodynamic effect of a coronary artery stenosis is a better predictor of prognosis than anatomical lumen obstruction. Until recently, no individual noninvasive test could provide both accurate coronary anatomy and lesion-specific myocardial ischaemia. However, computer tomography (CT) fractional flow reserve, which can be calculated from a standard CT coronary angiogram, was recently demonstrated to accurately detect and rule out the haemodynamic significance of individual coronary artery stenoses.

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Prognostic Value of High-Dose Dobutamine Stress Magnetic Resonance Imaging in 1,493 Consecutive Patients

Cited by 114 publications

References 27 publications

The Prognostic Value of Normal Stress Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease

The Prognostic Value of Normal Stress Cardiac Magnetic Resonance in Patients With Known or Suspected Coronary Artery Disease

2013 Esc Guidelines on the Management of Stable Coronary Artery Disease

CT fractional flow reserve: the next level in non-invasive cardiac imaging

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