Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas

Piffkó, J.; Bànkfalvi, Àgnes; Öfner, Dietmar; Bryne, Magne; Rasch, D; Joos, Ulrich; Böcker, W.; Kw, Schmid

doi:10.1038/bjc.1997.263

Cited by 76 publications

(68 citation statements)

References 20 publications

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“…Low mortality in this case may hide the significance of some individual prognostic markers, since patients outcome is most likely affected more by the effective diagnostic and treatment strategies than by any of the biological variables. The prognosis was significantly better in younger patients (26 -70 years), in patients with lower clinical stages of the tumours (TNM I and II) and in patients with lower (5 -10) Bryne's malignancy score as has been shown earlier by us (Kantola et al, 2000) and other investigators (Piffko et al, 1997). Our results were in line with Teixeira et al (1996), who also did not find a correlation between the thickness of the cancer in the deepest tumour areas and outcome of the patients, but in contrast with a study by Charoenrat et al (2003) where tumour thickness and survival of the tongue SCC patients correlated significantly.…”

Section: Discussionsupporting

confidence: 55%

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

et al. 2008

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Squamous cell carcinoma (SCC) of the tongue is the most common cancer in the oral cavity and has a high mortality rate. A total of 90 mobile tongue SCC samples were analysed for Bryne's malignancy scores, microvascular density, and thickness of the SCC sections. In addition, the staining pattern of cyclooxygenase-2, avb6 integrin, the laminin-5 g2-chain, and matrix metalloproteinases (MMPs) -2, -7, -8, -9, -20, and -28 were analysed. The expression of MMP-8 (collagenase-2) was positively associated with improved survival of the patients and the tendency was particularly prominent in females. No sufficient evidence for a correlation with the clinical outcome was found for any other immunohistological marker. To test the protective role of MMP-8 in tongue carcinogenesis, MMP-8 knockout mice were used. MMP-8 deficient female mice developed tongue SCCs at a significantly higher incidence than wildtype mice exposed to carcinogen 4-Nitroquinoline-N-oxide. Consistently, oestrogen-induced MMP-8 expression in cultured HSC-3 tongue carcinoma cells, and MMP-8 cleaved oestrogen receptor (ER) a and b. According to these data, we propose that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs.

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Section: Discussionsupporting

confidence: 55%

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

et al. 2008

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“…In keeping with findings from previously published semiquantitative studies (Bryne et al, 1998;Piffko et al, 1997a), the present study included a separate analysis of tissue architecture in the invasive front of the carcinomas.…”

mentioning

confidence: 64%

“…In carcinomas, clonal expansion and progression of stem lines result in heterogeneously composed tumors, consisting of subdivisions that have different aggressiveness in the growth pattern towards neighboring tissues (Heppner, 1993;Heppner and Miller, 1998). Based on the assumption that tumor biology somehow finds a morphologic expression, there are compelling reasons to assume that the invasive front of a carcinoma should contain morphologic information of particular clinical importance (Bryne et al, 1991(Bryne et al, , 1998Piffko et al, 1997a). In the present paper, we demonstrate that, in particular, the invasive front of OSCC contains morphologic information with high prognostic value.…”

Section: Sudbø Et Almentioning

confidence: 99%

Prognostic Value of Graph Theory-Based Tissue Architecture Analysis in Carcinomas of the Tongue

Sudbø

Bànkfalvi

Bryne

et al. 2000

Laboratory Investigation

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SUMMARY:Several studies on oral squamous cell carcinomas (OSCC) suggest that the clinical value of traditional histologic grading is limited both by poor reproducibility and by low prognostic impact. However, the prognostic potential of a strictly quantitative and highly reproducible assessment of the tissue architecture in OSCC has not been evaluated. Using image analysis, in 193 cases of T1-2 (Stage I-II) OSCC we retrospectively investigated the prognostic impact of two graph theory-derived structural features: the average Delaunay Edge Length (DEL_av) and the average homogeneity of the Ulam Tree (ELH_av). Both structural features were derived from subgraphs of the Voronoi Diagram. The geometric centers of the cell nuclei were computed, generating a two-dimensional swarm of point-like seeds from which graphs could be constructed. The impact on survival of the computed values of ELH_av and DEL_av was estimated by the method of Kaplan and Meier, with relapse-free survival and overall survival as end-points. The prognostic values of DEL_av and ELH_av as computed for the invasive front, the superficial part of the carcinoma, the total carcinoma, and the normal-appearing oral mucosa were compared. For DEL_av, significant prognostic information was found in the invasive front (p Ͻ 0.001). No significant prognostic information was found in superficial part of the carcinoma (p ϭ 0.34), in the carcinoma as a whole (p ϭ 0.35), or in the normal-appearing mucosa (p ϭ 0.27). For ELH_av, significant prognostic information was found in the invasive front (p ϭ 0.01) and, surprisingly, in putatively normal mucosa (p ϭ 0.03). No significant prognostic information was found in superficial parts of the carcinoma (p ϭ 0.34) or in the total carcinoma (p ϭ 0.11). In conclusion, strictly quantitative assessment of tissue architecture in the invasive front of OSCC yields highly prognostic information.

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“…including head and neck squamous cell carcinomas. have shown that the mAgNOR counts were higher in tumours with poor prognosis than in those with good prognosis (Contractor et al 1989: Ruschoff et al 1990: Ofner et al 1990: Kolar et al 1992: Delahunt et al 1993: Piffko et al 1997. With increasing mAgNOR counts.…”

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confidence: 99%

Bax expression has prognostic significance that is enhanced when combined with AgNOR counts in glottic carcinomas

Xie

Clausen²,

Angelis³

et al. 1998

Br J Cancer

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Recently. a family of genes whose encoded proteins share amino acid sequence homology with Bcl-2 have been identified. This family of proteins include Bcl-2. Bcl-x and Mcl-l. which act as blockers of apoptosis. whereas others such as Bax and Bak appear to promote apoptosis (Oltvai. 1993: Boise et al. 1995. The biological mechanisms by which the Bcl-2 gene family regulate apoptosis remain uncertain. The Bax protein seems. however. to act as a central regulator within this multigene family. Several studies have demonstrated that increased Bax expression is associated with increased radio-and chemosensitivity to induction of apoptosis (Bargou et al. 1996: Chresta et al. 1996: Kitada et al. 1996: Sakakura et al. 1996: Stoetzer et al. 1996: Thomas et al. 1996: Wagener et al. 1996. Information regarding the prognostic significance of Bax in human tumours is scarce. It has, however, been shown that reduced Bax expression correlates with tumour progression and shortened sunrival in breast adenocarcinomas (Krajewski et al. 1995).Moreover. it has been demonstrated that the bcl-2/bax mRNA expression ratio represents a prognostic marker in low-grade urinary

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Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas

Cited by 76 publications

References 20 publications

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

Prognostic Value of Graph Theory-Based Tissue Architecture Analysis in Carcinomas of the Tongue

Bax expression has prognostic significance that is enhanced when combined with AgNOR counts in glottic carcinomas

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