Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis

Cai, Lu; Yu, Jia-Kuo; Yu, Jinming; Peng, Yuan; Ullah, Habib; Chen, Yi; Lin, Jianxiong; Yang, Xiao; Yu, Xueqing

doi:10.1186/s12882-018-1092-1

Cited by 17 publications

(24 citation statements)

References 33 publications

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“…Didier et al 32 reported that the level of CRP was linked to the prevalence of microinflammation in PD patients, and they confirmed that a high CRP level was an independent risk factor for CVD events in PD patients. Furthermore, Liu et al 20 found that as a more sensitive inflammation masker, a high hs‐CRP level during follow‐up was identified as an independent predictor of mortality in PD patients, and every 1 mg/L increase in the hs‐CRP level was independently predictive of a 1.4% increase in mortality.In addition, other studies have proven that some combinations of several single markers in the forms of ratios or scoring systems proposed in recent years, such as the Glasgow prognostic score (GPS), 33 neutrophil‐to‐lymphocyte ratio (NLR) 34 and platelet‐to‐lymphocyte ratio (PLR), 35 are associated with mortality in PD patients.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen/Albumin ratio: A more powerful prognostic index for patients with end‐stage renal disease

Zou

Zhu

Zhou

et al. 2020

Eur J Clin Investigation

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Background Microinflammation is linked to an increased risk of death due to cardiovascular disease (CVD) in patients with end‐stage renal disease (ESRD). Although the fibrinogen/albumin ratio (FAR), a novel inflammatory marker, has been shown to predict mortality in various diseases, limited evidence is available for its role in ESRD. The purpose of this study is to explore the prognostic value of the FAR in ESRD patients on peritoneal dialysis (PD). Methods In this retrospective observational study, we enrolled patients with ESRD who underwent PD therapy in our hospital between 1 January 2011 and 31 December 2017. The Kaplan‐Meier method and Cox proportional hazards models were used to determine the contact between the FAR level and mortality. Results A total of 562 patients were enrolled in our research. The median FAR was 0.12, and patients were divided into two groups (low FAR group: FAR < 0.12, n = 250, and high FAR group: FAR ≥ 0.12, n = 312) according to the median FAR. Kaplan‐Meier curves showed that the cumulative incidences of both all‐cause mortality and CVD mortality were significantly higher in patients with FAR ≥ 0.12 (both P < .001). In multivariable analysis, the high FAR group had an important increased risk of all‐cause and CVD mortality (HR: 1.80; 95% CI: 1.03‐3.14, P = .038 and HR: 2.31; 95% CI: 1.17‐4.59, P = .016, respectively). Conclusions Our results suggest that a high baseline FAR value is an independent prognostic factor in ESRD patients on PD.

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Section: Discussionmentioning

confidence: 99%

Fibrinogen/Albumin ratio: A more powerful prognostic index for patients with end‐stage renal disease

Zou

Zhu

Zhou

et al. 2020

Eur J Clin Investigation

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“…For instance, commonly accepted nutritional markers, such as serum albumin (ALB) level, serum creatinine (Cr) level, hemoglobin (Hb) level, and body mass index (BMI), might be used to assess prognosis of patients with chronic kidney disease (CKD) [5,6]. However, other studies reported a poor predictive value of serum ALB, serum Cr, and other characteristics of PD patients for all-cause mortality or cardiovascular outcomes [7,8]. Furthermore, the prognostic values of various physiological ions have not been well determined [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for mortality in patients undergoing peritoneal dialysis: a systematic review and meta-analysis

Zhang

et al. 2021

Renal Failure

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Aim: Inconsistent investigations of the risk factors for all-cause mortality in patients undergoing peritoneal dialysis (PD) were reported. The present meta-analysis aimed to assess the impact of some clinical characteristics on the risk of mortality in PD patients. Methods: PubMed and Embase were systematically searched for studies evaluating the risk factors for all-cause mortality in PD patients. Hazard ratio (HR) and 95% confidence interval (CI) were derived using a random-effect or fixed-effect model considering the heterogeneity across studies. Result: A total of 26 studies were included in this meta-analysis in accordance with the inclusion and exclusion criteria. Age, primary cardiovascular diseases, diabetes mellitus, and high level of alkaline phosphatase showed significant positive associations with elevated risk of all-cause and cardiovascular mortality in PD patients, while hemoglobin acted as a benefit factor. Furthermore, early onset of peritonitis, high peritoneal transport status, elevated body mass index and highsensitivity C-reactive protein could also considerably increase the risk of all-cause mortality. The absolute serum level of magnesium, potassium, and uric acid required to improve survival in PD patients should be verified further. Conclusions: Multiple factors could affect the risk of mortality in PD patients.

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“…A similar association was also indicated in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Cai et al ( 28 ) conducted a retrospective cohort study of 1,501 patients with CAPD and found a robust and consistent association between lower PNI value (<45) and overall mortality or CVD mortality that was independent of other common risk factors (HR=1.82; 95% CI, 1.36-2.43; HR=1.63; 95% CI, 1.06-2.51). Additionally, PNI was a prognostic factor in patients undergoing kidney transplantation and in patients undergoing peritoneal dialysis ( 25 , 29 ).…”

Section: Discussionmentioning

confidence: 95%

Prognostic nutritional index predicts acute kidney injury and mortality of patients in the coronary care unit

Cao

Wang

et al. 2020

Exp Ther Med

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The current study aimed to investigate whether prognostic nutritional index (PNI) is an independent predictor of acute kidney injury (AKI) and mortality of patients in the coronary care unit (CCU). In the present two-stage observational study of patients in the CCU, 6,444 patients from the Medical Information Mart for Intensive Care (MIMIC) III database were first enrolled (test cohort), after which 412 patients from Zhongnan Hospital of Wuhan University were recruited in the validation cohort. AKI was defined based on the Kidney Disease Improving Global Outcomes AKI criteria. The primary endpoint was the incidence of AKI stratified by severity, while the second endpoint included in-hospital mortality and 2-year mortality. In the test cohort, 4,457 (69.2%) patients developed AKI during hospitalization. Following multivariable adjustment, the highest quartile of the PNI value was associated with a 1.8-fold increased risk of AKI compared with the lowest quartile. For the prediction of AKI, the area under the receiver operating characteristic curve outperformed the acute physiology score III score and clinical model in patients with or without preexisting chronic kidney disease, and this was further validated in the hospital cohort used in the present study. A total of 2,219 patients suffered mortality during the 2-year follow-up, and PNI was indicated to independently predict the risk of in-hospital mortality and 2-year mortality in the test cohort and in the validation cohort. Decision curve analysis indicated that the PNI values were clinically useful; Therefore, the current study demonstrated that the PNI value is an independent predictor of AKI and mortality in patients within the CCU.

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Prognostic value of inflammation-based prognostic scores on outcome in patients undergoing continuous ambulatory peritoneal dialysis

Cited by 17 publications

References 33 publications

Fibrinogen/Albumin ratio: A more powerful prognostic index for patients with end‐stage renal disease

Fibrinogen/Albumin ratio: A more powerful prognostic index for patients with end‐stage renal disease

Risk factors for mortality in patients undergoing peritoneal dialysis: a systematic review and meta-analysis

Prognostic nutritional index predicts acute kidney injury and mortality of patients in the coronary care unit

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