Prognostic value of inflammatory and nutritional markers for hepatocellular carcinoma

Xu, Yingying; Yuan, Xianrui; Zhang, Xiaomin; Hu, Wenxian; Wang, Zehua; Yao, Longdi; Zong, Liang

doi:10.1097/md.0000000000026506

Cited by 21 publications

(15 citation statements)

References 39 publications

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“…Elevated PLR is associated with increased all-cause mortality in different conditions [120], is a prognostic marker in many cancers [121] and is also associated with nutritional status [122]. As a marker of nutrition, PLR was significantly correlated with PNI and BMI in pancreatic cancer patients [87]; along with NLR was significantly associated with PNI in hepatocellular carcinoma [123]. PLR is also associated with haemoglobin and post-op complications in colorectal cancer patients affecting morbidity rates [124].…”

Section: Inflammation Scoresmentioning

confidence: 99%

Inflammation-Based Markers of Nutrition in Cancer Patients

Izuegbuna¹

2023

Combating Malnutrition Through Sustainable Approaches

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Malnutrition and cachexia are common findings in cancer patients, and they predict poorer clinical outcomes. Close to half of cancer patients regardless of cancer type have malnutrition and will require one form of nutritional support either before or during treatment. The early identification of malnutrition is thus important to physicians and caregivers. The role of inflammation in the development and progression of malnutrition and cachexia is being unravelled. Increasing evidence shows that systemic inflammatory response and nutritional status are involved in tumour development and influence the clinical prognosis. Serum proteins such as albumin and prealbumin have traditionally been used by physicians to determine patient nutritional status. More recently, inflammation-based prognostic scores including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), C reactive protein-to-albumin ratio (CAR), prognostic nutritional index (PNI), Glasgow Prognostic Score (GPS) have shown promise and have begun to be used in clinical practice to predict prognosis of cancer patients. This chapter highlights the role and pathophysiology of inflammation-based markers in assessing malnutrition and cachexia and their relationship to clinical screening tools.

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Section: Inflammation Scoresmentioning

confidence: 99%

Inflammation-Based Markers of Nutrition in Cancer Patients

Izuegbuna¹

2023

Combating Malnutrition Through Sustainable Approaches

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“…[23] Recently, the association of gallbladder wall thickness with hepatic decompensation has been explored in some cross-sectional studies. [7,[24][25][26] Elkerdawy et al [7] found that gallbladder wall thickness was associated with the presence of esophageal varices in patients with cirrhosis. Mohammadi et al [25] demonstrated that thickened gallbladder wall was highly predictive for the presence of ascites in liver cirrhosis.…”

Section: Journal Of Translational Internal Medicine / Aopmentioning

confidence: 99%

Associations of gallbladder and gallstone parameters with clinical outcomes in patients with cirrhosis

Ding

Yin

Zhu

et al. 2023

Journal of Translational Internal Medicine

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Background Morphologic changes in the gallbladder and gallstones are common in cirrhotic patients, but their associations with outcomes of cirrhotic patients are unclear. Methods We retrospectively enrolled 206 cirrhotic patients and measured their gallbladder length and width, gallbladder wall thickness, presence of gallstones, and gallstones’ length and width in axial contrast-enhanced computed tomography (CT) images. X-tile software was utilized to calculate the optimal cutoff values of these parameters for evaluating survival and hepatic decompensation events in the cirrhosis group. Their associations with survival were explored by Cox regression analyses and Kaplan–Meier curve analyses. Their associations with hepatic decompensation events were evaluated by competing risk analyses and Nelson-Aalen cumulative risk curve analyses where death was a competing event. Results Cirrhotic patients with gallbladder length < 72 mm had a significantly higher cumulative survival rate than those with a length of ≥ 72 mm (P = 0.049 by log-rank test), but gallbladder width, gallbladder wall thickness, presence of gallstones, and gallstones’ length and width were not significantly associated with survival (P = 0.10, P = 0.14, P = 0.97, P = 0.73, and P = 0.73 by log-rank tests, respectively). Cirrhotic patients with gallbladder wall thickness < 3.4 mm had a significantly lower cumulative rate of hepatic decompensation events than those with a wall thickness of ≥ 3.4 mm (P = 0.02 by Gray’s test), but gallbladder length and width, presence of gallstones, and gallstones’ length and width were not significantly associated with hepatic decompensation events (P = 0.15, P = 0.15, P = 0.54, P = 0.76, and P = 0.54 by Gray’s tests, respectively). Conclusion Changes in gallbladder length and gallbladder wall thickness, rather than gallstone parameters, may be in parallel with the long-term outcomes of cirrhotic patients.

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“…Liver cancer is one of the leading causes of cancer death worldwide (Sun et al, 2013;Zhao et al, 2015;Kido et al, 2020). Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer (Ahn et al, 2018;Xu et al, 2021). Numerous studies have recently revealed that DUXAP10 was overexpressed in HCC cell lines (including Hep3B, HepG2, SMMC7721, HuH7, MHCC-97L, MHCC-97H, HCC-LM, and SK-Hep-1 cells) and tissues (Zhu et al, 2018;Han et al, 2019;Sun et al, 2019).…”

Section: Liver Cancermentioning

confidence: 99%

The LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer

Zhao

Dong

et al. 2022

Front. Cell Dev. Biol.

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Cancer is one of the most prevalent and deadliest diseases globally, with an increasing morbidity of approximately 14 million new cancer cases per year. Identifying novel diagnostic and prognostic biomarkers for cancers is important for developing cancer therapeutic strategies and lowering mortality rates. Long noncoding RNAs (lncRNAs) represent a group of noncoding RNAs of more than 200 nucleotides that have been shown to participate in the development of human cancers. The novel lncRNA DUXAP10 was newly reported to be abnormally overexpressed in several cancers and positively correlated with poor clinical characteristics of cancer patients. Multiple studies have found that DUXAP10 widely regulates vital biological functions related to the development and progression of cancers, including cell proliferation, apoptosis, invasion, migration, and stemness, through different molecular mechanisms. The aim of this review was to recapitulate current findings regarding the roles of DUXAP10 in cancers and evaluate the potential of DUXAP10 as a novel biomarker for cancer diagnosis, treatment, and prognostic assessment.

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Prognostic value of inflammatory and nutritional markers for hepatocellular carcinoma

Cited by 21 publications

References 39 publications

Inflammation-Based Markers of Nutrition in Cancer Patients

Inflammation-Based Markers of Nutrition in Cancer Patients

Associations of gallbladder and gallstone parameters with clinical outcomes in patients with cirrhosis

The LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer

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