Prognostic value of interleukin-1 beta levels after acute brain injury

Taşçi, Alptekin; Okay, Onder; Gezici, Ali Rıza; Ergün, Rüçhan; Ergüngör, Fikret

doi:10.1179/016164103771953998

Cited by 45 publications

(17 citation statements)

References 24 publications

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“…Furthermore, we are aware of only one previous report that evaluated IL-10 in isolated TBI patients dichotomized by injury severity, albeit in a population of 26 patients that assessed injury severity at 7 days post-injury [ 50 ]. Also, in agreement with previous research, unfavorable patient outcome and mortality were associated with elevated peripheral concentrations of IL-1β, IL-10, and TNF-α [ 32 , 37 , 46 , 48 ]. Importantly, the relationships between cytokines and patient outcome were significant even after controlling for injury severity, suggesting a possible independent role of these mediators in secondary injury pathogenesis.…”

Section: Discussionsupporting

confidence: 92%

Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury

Battista

Rhind

Hutchison

et al. 2016

J Neuroinflammation

150

115

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BackgroundTraumatic brain injury (TBI) elicits intense sympathetic nervous system (SNS) activation with profuse catecholamine secretion. The resultant hyperadrenergic state is linked to immunomodulation both within the brain and systemically. Dysregulated inflammation post-TBI exacerbates secondary brain injury and contributes to unfavorable patient outcomes including death. The aim of this study was to characterize the early dynamic profile of circulating inflammatory cytokines/chemokines in patients admitted for moderate-to-severe TBI, to examine interrelationships between these mediators and catecholamines, as well as clinical indices of injury severity and neurological outcome.MethodsBlood was sampled from 166 isolated TBI patients (aged 45 ± 20.3 years; 74.7 % male) on admission, 6-, 12-, and 24-h post-injury and from healthy controls (N = 21). Plasma cytokine [interleukin (IL)-1β, -2, -4, -5, -10, -12p70, -13, tumor necrosis factor (TNF)-α, interferon (IFN)-γ] and chemokine [IL-8, eotaxin, eotaxin-3, IFN-γ-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, -4, macrophage-derived chemokine (MDC), macrophage inflammatory protein (MIP)-1β, thymus activation regulated chemokine (TARC)] concentrations were analyzed using high-sensitivity electrochemiluminescence multiplex immunoassays. Plasma catecholamines [epinephrine (Epi), norepinephrine (NE)] were measured by immunoassay. Neurological outcome at 6 months was assessed using the extended Glasgow outcome scale (GOSE) dichotomized as good (>4) or poor (≤4) outcomes.ResultsPatients showed altered levels of IL-10 and all chemokines assayed relative to controls. Significant differences in a number of markers were evident between moderate and severe TBI cohorts. Elevated IL-8, IL-10, and TNF-α, as well as alterations in 8 of 9 chemokines, were associated with poor outcome at 6 months. Notably, a positive association was found between Epi and IL-1β, IL-10, Eotaxin, IL-8, and MCP-1. NE was positively associated with IL-1β, IL-10, TNF-α, eotaxin, IL-8, IP-10, and MCP-1.ConclusionsOur results provide further evidence that exaggerated SNS activation acutely after isolated TBI in humans may contribute to harmful peripheral inflammatory cytokine/chemokine dysregulation. These findings are consistent with a potentially beneficial role for therapies aimed at modulating the inflammatory response and hyperadrenergic state acutely post-injury.Electronic supplementary materialThe online version of this article (doi:10.1186/s12974-016-0500-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 92%

Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury

Battista

Rhind

Hutchison

et al. 2016

J Neuroinflammation

150

115

View full text Add to dashboard Cite

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“…Though we did not identify differences in a number of previously identified TBI inflammatory markers such as IL-1β, IL-6 and IL-10, these markers have typically been evaluated in the acute stages after severe TBI [ 52 , 76 – 78 ]; conversely, our cohort was ostensibly healthy, and the median time from last concussion was approximately two years ( Table 1 ). Furthermore, while numerous cytokines have been found elevated for up to three months after severe TBI [ 79 ], few studies have evaluated the chronic inflammatory response after concussion.…”

Section: Discussionmentioning

confidence: 80%

Altered Blood Biomarker Profiles in Athletes with a History of Repetitive Head Impacts

et al. 2016

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The long-term health effects of concussion and sub-concussive impacts in sport are unknown. Growing evidence suggests both inflammation and neurodegeneration are pivotal to secondary injury processes and the etiology of neurodegenerative diseases. In the present study we characterized circulating brain injury and inflammatory mediators in healthy male and female athletes according to concussion history and collision sport participation. Eighty-seven university level athletes (male, n = 60; female, n = 27) were recruited before the start of the competitive season. Athletes were healthy at the time of the study (no medications, illness, concussion or musculoskeletal injuries). Dependent variables included 29 inflammatory and 10 neurological injury analytes assessed in the peripheral blood by immunoassay. Biomarkers were statistically evaluated using partial least squares multivariate analysis to identify possible relationships to self-reported previous concussion history, number of previous concussions and collision sport participation in male and female athletes. Multiple concussions were associated with increases in peripheral MCP-1 in females, and MCP-4 in males. Collision sport participation was associated with increases in tau levels in males. These results are consistent with previous experimental and clinical findings that suggest ongoing inflammatory and cerebral injury processes after repetitive mild head trauma. However, further validation is needed to correlate systemic biomarkers to repetitive brain impacts, as opposed to the extracranial effects common to an athletic population such as exercise and muscle damage.

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“…From previous studies it is known that intensity of inflammation may predict the extent of brain damage [34], and consequently clinical presentation and outcome [35]. Moreover, we recently reported that a functional polymorphism in the IL-1RN gene was associated with hemorrhagic events after traumatic brain injury [31].…”

Section: Discussionmentioning

confidence: 99%

Alpha-1 Antichymotrypsin Gene Signal Peptide A/T Polymorphism and Primary Intracerebral Hemorrhage

et al. 2008

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Background/Aims: Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology. The TT genotype of the ACT signal peptide A/T polymorphism has been reported to confer susceptibility to primary intracerebral hemorrhage (PICH). We conducted a prospective study to test possible association of ACT signal peptide A/T polymorphism with PICH in a Greek cohort with enough power (80%) to detect a twofold increase in the odds ratio. Methods: We prospectively recruited 147 patients with PICH. ACT signal peptide A/T genotypes were determined in patients and 206 healthy, age- and sex-matched control subjects from the neurology outpatient clinic using the polymerase chain reaction restriction fragment length polymorphism method. Results: Our study did not show an association between ACT signal peptide A/T polymorphism and PICH. We also failed to find any influence on age at onset, the location and volume of PICH as well as on clinical severity at admission or 6-month outcome. Conclusion: Our data failed to confirm an association between ACT signal peptide A/T polymorphism and PICH. However, we cannot exclude the possibility that the TT genotype confers susceptibility at less than a twofold increase.

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Prognostic value of interleukin-1 beta levels after acute brain injury

Cited by 45 publications

References 24 publications

Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury

Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury

Altered Blood Biomarker Profiles in Athletes with a History of Repetitive Head Impacts

Alpha-1 Antichymotrypsin Gene Signal Peptide A/T Polymorphism and Primary Intracerebral Hemorrhage

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