Prognostic Value of Isolated Sarcopenia or Malnutrition–Sarcopenia Syndrome for Clinical Outcomes in Hospitalized Patients

Sousa, Iasmin Matias de; Burgel, Camila Ferri; Silva, Flávia Moraes; Fayh, Ana Paula Trussardi

doi:10.3390/nu14112207

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…Malnutrition and sarcopenia overlap was found in 15.9% of patients in the current study. Malnutrition and sarcopenia share characteristics in common, leading to the suggestion of the existence of malnutrition‐sarcopenia syndrome (MSS) by Vandewoude et al 29 The presence of MSS has been associated with a fourfold increase in the chance of mortality in hospitalized older adult patients as analyzed by Hu et al 30 Sousa et al also found an association between MSS and longer hospital stays, hospital readmissions, and mortality in hospitalized patients 13 . However, it has been scarcely explored in outpatients with HF.…”

Section: Discussionmentioning

confidence: 99%

“…11 The presence of malnutrition combined with sarcopenia has already been demonstrated to be associated with a poor prognosis in older adults 12 and in general hospitalized patients. 13 The prognostic value of malnutrition 5 and sarcopenia 14 diagnosis in patients with HF is well recognized, and poor quality of life is related to these diagnoses. However, we did not identify studies investigating whether the combination of both conditions are more deleterious for this population.…”

Section: Introductionmentioning

confidence: 99%

“…Also, a prospective study with 200 patients with HF in outpatient follow‐up shows that reduction in muscle function can impact the quality of life of these patients 11 . The presence of malnutrition combined with sarcopenia has already been demonstrated to be associated with a poor prognosis in older adults 12 and in general hospitalized patients 13 . The prognostic value of malnutrition 5 and sarcopenia 14 diagnosis in patients with HF is well recognized, and poor quality of life is related to these diagnoses.…”

Section: Introductionmentioning

confidence: 99%

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Association between isolated or combined malnutrition and sarcopenia and quality of life in heart failure outpatients: A cross‐sectional study

Knobloch,

Souza,

Vale

et al. 2024

J Parenter Enteral Nutr

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BackgroundHeart failure (HF) is a chronic condition with symptoms linked to worse quality of life. Malnutrition and sarcopenia are conditions frequently found in patients with HF. This study aims to evaluate the association between isolated or combined malnutrition and sarcopenia and quality of life in outpatients with HF.MethodsThis is a cross‐sectional study with a sample of outpatients with HF aged ≥18 years. Malnutrition was assessed according to the criteria of the Global Leadership Initiative on Malnutrition, and sarcopenia was evaluated by the European Working Group on Sarcopenia in Older People. Quality of life was assessed using the Minnesota Living with HF questionnaire (MLHFQ). Clinical and sociodemographic data were collected.ResultsOne hundred and fifty‐one patients were included in this study, with a median (interquartile range) age of 58 (48–65) years, 58.9% were adults, and 68.9% were male. A total of 29.5% of the patients were malnourished, and 28.5% and 2.6% were identified with probable sarcopenia and sarcopenia, respectively. Of the total, 15.9% of patients were identified with both conditions. Sarcopenia was associated with higher odds of increase in the MLHFQ total score, indicating worse quality of life (odds ratio [OR] = 3.61; 95% CI, 1.65–7.89). The same was found in the presence of two conditions (OR 3.97; 95% CI, 1.32–11.54), whereas isolated malnutrition was not related to life quality (OR = 1.62; 95% CI, 0.73–3.60).ConclusionThe presence of malnutrition and sarcopenia simultaneously were associated with worse quality of life scores when compared with these isolated conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between isolated or combined malnutrition and sarcopenia and quality of life in heart failure outpatients: A cross‐sectional study

Knobloch,

Souza,

Vale

et al. 2024

J Parenter Enteral Nutr

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“…These results are in line with other research that found a connection between MSS and extended duration of stay and readmission. For instance, MSS was discovered in research by Sousa et al [35] to be a predictor of worse outcomes in hospitalized patients. A deterioration in nutritional status during the rst week of hospitalization was linked to a higher risk of an extended duration of stay and readmission, according to impactful research by Correia et al [37].…”

Section: Discussionmentioning

confidence: 99%

The Triad of Physiological Challenges: Investigating the Intersection of Sarcopenia, Malnutrition, and Malnutrition-Sarcopenia Syndrome in COPD Patients - A Cross-Sectional Study

Patel,

Makwana

et al. 2023

Preprint

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BACKGROUND One of the most prevalent respiratory disorders in modern society is chronic obstructive pulmonary disease (COPD). Frequent comorbidities in COPD patients are abnormal nutritional status and body composition variations. Malnutrition-sarcopenia syndrome, which occurs when the two conditions – malnutrition and sarcopenia – coexist, raises the risk of death more than either condition alone. The current study sought to determine the prevalence of malnutrition, sarcopenia, and malnutrition-sarcopenia syndrome in COPD patients as well as the association between these diseases and the severity of COPD. METHODS The study was a cross-sectional study conducted on hospitalized COPD patients. The sample size of the study was calculated to be 160. A self-structured questionnaire was used to collect the data, containing sociodemographic characteristics, clinical profiles, anthropometric assessment, and bioimpedance indices. Hand grip was measured by a Hand Dynamometer. Assessment of the risk of malnutrition was performed using the Mini Nutritional Assessment-Short Form questionnaire and was confirmed by GLIM criteria. The COPD assessment test (CAT) tool determined the severity of the condition. For the data analysis, comparisons were made using Student’s t test and Mann–Whitney test in bivariate analysis. Multivariate logistic regression analyses were performed considering the outcomes of COPD patients by CAT scores, prolonged length of stay, and hospital readmission six months after discharge. RESULTS The mean age of the participants was 48±5 years. Approximately 61.9% were found to be sarcopenic. Approximately 45.6% of study subjects had malnutrition. Malnutrition sarcopenia syndrome was diagnosed in 38.1% of patients. The study analysis revealed that COPD patients with malnutrition-sarcopenia syndrome had more than twice the odds of prolonged hospital stay, re-admission within 6 months, and higher CAT scores. CONCLUSION The study revealed a high prevalence of sarcopenia, malnutrition, and malnutrition sarcopenia syndrome in patients with COPD. These conditions were found to be statistically significant with prolonged length of stay, re-admission within 6 months, and CAT scores. The findings highlight the importance of addressing these conditions as part of the management of the patients.

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“…At the same time, proteolysis leads the negative nitrogen balance. When this catabolic phase is severe, many patients tend to have a poor prognosis [3][4][5][6][7][8][9] . This trend applies to critically ill and neurological critically ill pa-tients 10) .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Nitrogen Balance Test in Patients With Traumatic Brain Injury

Kim

2023

J Neurointensive Care

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Background: This study aimed to analyze the catabolic phases of patients with traumatic brain injury (TBI) by performing the Nitrogen Balance Test (NB Test).Methods: This single-centered, retrospective study included data from 292 patients who underwent NB tests from 2019 to 2022 and categorized them as TBI and Non-TBI groups. The basic clinical factors (gender, age, and initial GCS), critical care factors (APACHE, SOFA, and ICU stay days), and outcomes (GOS). The trend of the NB test was investigated in all groups and analyzed the statistical correlation of the NB test was with severity, critical care factors, and outcomes. Results: A total of 52 patients were found to have TBI. The 26 out of 52 TBI patients underwent the second NB test 1 week after the first NB test. The deficiency of protein calculated was 24.375 g. There was a significant statistical difference of NB test patterns between the non-TBI and TBI patients.Conclusion: Physicians should be aware of the catabolic phases of acute TBI events indicating notable protein loss in the patients. Therefore, we should consider the additional supply of protein when managing TBI patients.

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Prognostic Value of Isolated Sarcopenia or Malnutrition–Sarcopenia Syndrome for Clinical Outcomes in Hospitalized Patients

Cited by 10 publications

References 42 publications

Association between isolated or combined malnutrition and sarcopenia and quality of life in heart failure outpatients: A cross‐sectional study

Association between isolated or combined malnutrition and sarcopenia and quality of life in heart failure outpatients: A cross‐sectional study

The Triad of Physiological Challenges: Investigating the Intersection of Sarcopenia, Malnutrition, and Malnutrition-Sarcopenia Syndrome in COPD Patients - A Cross-Sectional Study

Analysis of Nitrogen Balance Test in Patients With Traumatic Brain Injury

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