Prognostic Value of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients

Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy – Comparative Strain Imaging Study –

“…In view of the relationships among myocardial structure, function and mid-term outcomes, a large body of literature indicates LV fibrosis as an additional cardiovascular prognosticator in HCM patients, particularly in those otherwise classified at a lower risk. 11,13,20- 22 More recently, Hen et al 22 found that progression of LGE on cMRI was related to increased wall thickness, decreased contractility, and reduced intraventricular pressure gradient in a Japanese population. The same group also demonstrated a greater incidence of atrial fibrillation in such patients, underlying a possible relationship between LA function and LV disarray.…”

QTc Interval Prolongation Predicts Arrhythmia Recurrence After Catheter Ablation of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy

“…16 As a cardiomyopathy, however, myocardial hypertrophy in HCM is not necessarily limited in ventricle but can also be seen in the atria. 17 Previous studies indicated that HCM is associated with cardiac electrophysiological changes, manifested as trial fibrillation (AF) is the most common arrhythmia and develops in approximately 20% of adult patients with hypertrophic cardiomyopathy (HCM). This arrhythmia can be present in approximately 5% of patients at the time of diagnosis, 1 and is associated with deterioration of clinical status and increased hospitalization, systemic thromboembolism, heart failure and death in HCM patients.…”

Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients

“…The arrhythmia event rate was higher in the group with marked LGE compared with the mild or no LGE group. 11 Given that the median LGE score in the present study was 3, the patients was classified into LGE absent or mild (LGE score ≤3) and LGE extensive (LGE score ≥4), and the clinical parameters compared between the 2 groups. On multivariate analysis increased wall thickness, lowered LVEF, and decreased intraventricular pressure gradient were independent factors associated with extensive LGE.…”