Prognostic value of late gadolinium enhancement in dilated cardiomyopathy patients: a meta-analysis

Early detection of myocardial involvement by T1 mapping of cardiac MRI in idiopathic inflammatory myopathy

“…The LGE technique at cardiac MRI is an accurate method to detect focal fibrosis with gadolinium‐based contrast agents and has proven to have significant prognostic implications in nonischemic cardiomyopathies . In our study, the LGE pattern localized in the midwall and/or the subepicardial layer, which was similar to previous reports as well as other autoimmune diseases .…”

Late Gadolinium Enhancement in Patients with Nonischemic Dilated Cardiomyopathy

“…This reaffirms that the presence or absence of scar detected by LGE‐CMR is very important in risk stratification of patients with cardiomyopathy. Our review extends the results of recent meta‐analysis by Duan et al . by specifically demonstrating the relationship between LGE and appropriate ICD discharge.…”

“…Recent meta‐analysis by Duan et al . involving 1,675 NIDM patients with mean follow‐up of 3 years demonstrated that LGE is associated with all‐cause mortality (odds ratio [OR]: 3.43, 95% confidence intervals [CIs]: 2.26–5.22, P < 0.00001), cardiac death/transplantation (OR: 3.65, 95% CI: 1.80–7.40, P < 0.0003), hospitalization for HF (OR: 2.87, 95% CI: 1.53–5.39, P < 0.001), major arrhythmic events (SCD,VT/VF, appropriate ICD discharge/pacing, and syncope (OR: 4.24, 95% CI: 2.95–6.08, P < 0.00001).…”

Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure

“…In addition, the presence of LGE and its extent in myocardial tissue relates to overall cardiovascular outcomes (Groves et al, 1989; Duan et al, 2015; Kato et al, 2015; Barbier et al, 2016; Birnie et al, 2016; Liu et al, 2016; Raina et al, 2016). Our team (Liu et al, 2016) reported that the amount of LGE from high-scale threshold on CMR correlated positively with the likelihood for adverse cardiovascular outcomes in patients with end stage C&D heart failure (adjusted hazard ratio, 1.46/10% increase in LGE; P = 0.002).…”

“…DCM is the most frequent indication for heart transplantation. Duan et al (2015) performed a meta-analysis to evaluate the association between LGE and major adverse events in DCM patients. In the meta-analysis, the presence of LGE was significantly associated with all-cause mortality, cardiac death/transplantation, hospitalization for heart failure, and SCD, suggesting that LGE might provide a reference for (1) risk stratification in deciding on preventive anti-arrhythmia treatments and (2) identification of patients who would benefit from more intensive clinical care for deteriorating heart failure.…”