Prognostic Value of Le^y and H Antigens in Oral Tongue Carcinomas

Abstract

The expression of H antigen and Le(y), especially their combination with proliferative or apoptotic markers, has prognostic value in tongue SCC.

Bag‐1 Expression as a Prognostic Factor in Tongue Squamous Cell Carcinomas

“…Our results revealed that the prognostic impact of Bag‐1 expression is improved when combined with other prognostic factors, especially when combined with Bax expression and AI. These observations are in agreement with our previous findings showing that combined evaluation of proliferative and apoptotic markers enhances their prognostic ability in discriminating between patients with favorable and unfavorable clinical outcome 12–14 . Because neoplastic progress is a complicated process with many genes involved, especially genes regulating proliferation and apoptosis, our findings indicate that a combination of different parameters, which represent different biologic features of tumor progression, may reflect broader aspects of tumor biology and thus give better prognostic information than the individual single parameters.…”

“…Bag‐1 expression was compared with clinical and histopathologic parameters and proliferation‐ and apoptosis‐related variables obtained from our previous investigations of the same material 12–14 . Bag‐1 expression correlated positively with T classification ( P = .0362), N classification ( P = .0284), and with clinical stage ( P = .0117).…”

“…The methods for evaluating other apoptosis‐ and proliferation‐related parameters such as Bax, Bcl‐2, apoptotic index (AI), p53 accumulation, Ki‐67, AgNOR, and Le y and H‐antigen were described previously 12–14 …”

“…In the present study, we investigated the prognostic significance of Bag‐1 expression in oral tongue SCC. In addition, the relationship between Bag‐1 expression and clinical parameters and our previously investigated proliferation‐ and apoptosis‐related parameters, such as Ki‐67, argyrophilic nucleolar organizer regions (AgNOR), Bcl‐2 and Bax expressions, spontaneous apoptosis, p53 accumulation, and H‐antigen and Le y , 12–14 were also studied.…”

ABH and Lewis histo‐blood group antigens in cancer

“…Conversely, in colorectal carcinomas, it is their presence which is a sign of unfavorable outcome (124). Overexpression of Leb, Ley or H is associated with a bad prognosis in carcinomas of the oesophagus, the distal colon, the lung, the breast and the tongue (39,(125)(126)(127)(128)(129)(130)(131). This is also the case for overexpression of sialylated antigens such as sialyl-Le", sialyl-Le" and dimeric sialyl-Le" for stomach, colon, lung, kidney, prostate as well as breast carcinomas (40,128,(132)(133)(134)(135)(136)(137)(138)(139)(140).…”