2022
DOI: 10.1002/hon.3025
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Prognostic value of lesion dissemination in doxorubicin, bleomycin, vinblastine, and dacarbazine‐treated, interimPET‐negative classical Hodgkin Lymphoma patients: A radio‐genomic study

Abstract: We evaluated the prognostic role of the largest distance between two lesions (Dmax), defined by positron emission tomography (PET) in a retrospective cohort of newly diagnosed classical Hodgkin Lymphoma (cHL) patients. We also explored the molecular bases underlying Dmax through a gene expression analysis of diagnostic biopsies. We included patients diagnosed with cHL from 2007 to 2020, initially treated with ABVD, with available baseline PET for review, and with at least two FDG avid lesions. Patients with av… Show more

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Cited by 26 publications
(35 citation statements)
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“…Dmax has been demonstrated to identify poor prognosis in patients with DLBCL, Hodgkin lymphoma or other lymphomas [29][30][31] , as a 3D feature simple to calculate with an intuitive interpretation. Although Dmax was less affected by height during the LNH073B study [29] , we think it is more reasonable to use body surface area to standardize Dmax, considering the consistency of comparison.…”
Section: Discussionmentioning
confidence: 99%
“…Dmax has been demonstrated to identify poor prognosis in patients with DLBCL, Hodgkin lymphoma or other lymphomas [29][30][31] , as a 3D feature simple to calculate with an intuitive interpretation. Although Dmax was less affected by height during the LNH073B study [29] , we think it is more reasonable to use body surface area to standardize Dmax, considering the consistency of comparison.…”
Section: Discussionmentioning
confidence: 99%
“…The study published by Durmo et al 15 . tested the capacity of D max to predict treatment outcome in a retrospective cohort of patients with classical HL treated with ABVD regimen confirming the prognostic role of this biomarker in this type of lymphoma.…”
mentioning
confidence: 85%
“…Their combination with MTV in predictive models showed a significant improvement of the prognostic value of the only tumor burden estimation (by MTV). [12][13][14] The study published by Durmo et al 15 tested the capacity of D max to predict treatment outcome in a retrospective cohort of patients with classical HL treated with ABVD regimen confirming the prognostic role of this biomarker in this type of lymphoma. In a multivariate analysis including the most common clinical parameters and baseline PET metrics (MTV, TLG and SUVmax), D max resulted the only independent predictor of PFS.…”
Section: Funding Informationmentioning
confidence: 98%
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