Prognostic value of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue

Colonia-García, Adriana; Salazar-Peláez, Lina María; Serna-Ortiz, C.A.; Álvarez-Sánchez, Luis Gonzalo; Andrade, Cléverton Roberto de

doi:10.1016/j.oooo.2021.08.021

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Histopathological tumor and nodal stages, LVI, PNI, surgical margin status and depth of invasion were shown as poor prognostic histopathological risk factors in TSCC (5)(6)(7)(8)(9)(19)(20)(21). In our study, TLG and MTV were significantly higher in higher pT stage (T3-T4) tumors, in the presence of LVI, PNI and positive surgical margin.…”

Section: Discussionsupporting

confidence: 54%

“…Nevertheless, the prognosis of patients within the same TNM stage may vary (4). In addition to TNM staging system, various histopathological risk factors (depth of invasion, perineural invasion [PNI], surgical margin status, lymphovascular invasion [LVI],) in resectable TSCC can be used to predict patient prognosis (5)(6)(7)(8)(9). However, histopathological prognostic markers can only be obtained after surgical resection.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic role of primary tumor metabolic-volumetric parameters of 18F-fluorodeoxyglucose positron emission tomography in tongue squamous cell carcinoma

Aydos

Cebeci

2023

Journal of Health Sciences and Medicine

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Aim: It was aimed to evaluate the prognostic role of primary tumor metabolic-volumetric parameters of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in resectable tongue squamous cell carcinoma (TSCC). Materials and Methods: The imaging findings of 44 TSCC patients (23 females, 21 males, mean age: 58 ± 12) with resectable tumors who underwent 18F-FDG PET/CT imaging for primary staging before surgery between 2010-2021 were evaluated retrospectively. Maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), metabolic tumor volume (MTV) of primary tumors were acquired from PET/CT. Histopathological risk factors (pathological tumor and nodal stage, perineural and lymphovascular invasion, depth of invasion, surgical margin positivity) obtained from surgical resection material of primary tumors were also recorded. The prognostic values of imaging and histopathological parameters were assessed by Cox proportional hazards regression models. Survival curves were estimated by using the Kaplan-Meier analysis. Results: The median follow-up period after diagnosis was 24 months (range: 2-152 months). The univariate and multivariate regression analyses demonstrated that MTV was the only parameter which was significantly related to prognosis for PFS and OS. The patients with higher MTV (> 3.13 cm3) had lower OS and PFS rates compared to those with lower MTV (≤ 3.13 cm3) (p = 0.002, p < 0.001, respectively). Conclusion: Primary tumor MTV is an independent prognostic factor in resectable TSCC. PET volumetric features can be used as prognostic biomarker to predict patients with poor prognosis.

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Prognostic role of primary tumor metabolic-volumetric parameters of 18F-fluorodeoxyglucose positron emission tomography in tongue squamous cell carcinoma

Aydos

Cebeci

2023

Journal of Health Sciences and Medicine

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Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles

Mastronikolis,

Delides,

Kyrodimos

et al. 2024

Mol Biol Rep

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The incidence of head and neck cancer (HNC), constituting approximately one in ten cancer cases worldwide, affects approximately 644,000 individuals annually. Managing this complex disease involves various treatment modalities such as systemic therapy, radiation, and surgery, particularly for patients with locally advanced disease. HNC treatment necessitates a multidisciplinary approach due to alterations in patients’ genomes affecting their functionality. Predominantly, squamous cell carcinomas (SCCs), the majority of HNCs, arise from the upper aerodigestive tract epithelium. The epidemiology, staging, diagnosis, and management techniques of head and neck squamous cell carcinoma (HNSCC), encompassing clinical, image-based, histopathological and molecular profiling, have been extensively reviewed. Lymph node metastasis (LNM) is a well-known predictive factor for HNSCC that initiates metastasis and significantly impacts HNSCC prognosis. Distant metastasis (DM) in HNSCC has been correlated to aberrant expression of cancer cell-derived cytokines and growth factors triggering abnormal activation of several signaling pathways that boost cancer cell aggressiveness. Recent advances in genetic profiling, understanding tumor microenvironment, oligometastatic disease, and immunotherapy have revolutionized treatment strategies and disease control. Future research may leverage genomics and proteomics to identify biomarkers aiding individualized HNSCC treatment. Understanding the molecular basis, genetic landscape, atypical signaling pathways, and tumor microenvironment have enhanced the comprehension of HNSCC molecular etiology. This critical review sheds light on regional and distant metastases in HNSCC, presenting major clinical and laboratory features, predictive biomarkers, and available therapeutic approaches.

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Prognostic impact of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue

Huang

Chen

et al. 2023

Sci Rep

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This study aimed to investigate the prognostic impact of lymphovascular and perineural invasions in patients with squamous cell carcinoma of the tongue who received surgery-based treatment at our institution between January 2013 and December 2020. Patients were divided into four groups based on the presence of perineural (P−/P +) and lymphovascular invasions (V−/V +): P–V−, P–V + , P + V−, and P + V + . Log-rank and Cox proportional hazard models were used to evaluate the association between perineural /lymphovascular invasion and overall survival (OS). Altogether, 127 patients were included, and 95 (74.8%), 8 (6.3%), 18 (14.2%), and 6 (4.7%) cases were classified as P–V−, P–V + , P + V−, and P + V + , respectively. Pathologic N stage (pN stage), tumor stage, histological grade, lymphovascular invasion, perineural invasion, and postoperative radiotherapy were significantly associated with OS (p < 0.05). OS was significantly different among the four groups (p < 0.05). Significant between-group differences in OS were detected for node-positive (p < 0.05) and stage III–IV (p < 0.05) cases. OS was the worst in the P + V + group. Lymphovascular and perineural invasions are independent negative prognostic factors for squamous cell carcinoma of the tongue. Patients with lymphovascular and/or perineural invasion may have significantly poorer overall survival than those without neurovascular involvement.

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Prognostic value of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue

Cited by 3 publications

References 36 publications

Prognostic role of primary tumor metabolic-volumetric parameters of 18F-fluorodeoxyglucose positron emission tomography in tongue squamous cell carcinoma

Prognostic role of primary tumor metabolic-volumetric parameters of 18F-fluorodeoxyglucose positron emission tomography in tongue squamous cell carcinoma

Insights into metastatic roadmap of head and neck cancer squamous cell carcinoma based on clinical, histopathological and molecular profiles

Prognostic impact of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue

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