Prognostic value of metabolic tumor volume measured by 18F-FDG PET/CT in advanced-stage squamous cell carcinoma of the larynx and hypopharynx

Park, G. C.; Kim, J. S.; Roh, Jong Lyel; Choi, Seung Ho; Nam, Soon Yuhl; Kim, S. Y.

doi:10.1093/annonc/mds247

Cited by 77 publications

(73 citation statements)

References 27 publications

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“…Either MTV (2,(15)(16)(17) or TLG (18) was measured in 5 studies, and both were measured in 8 studies (8,(19)(20)(21)(22)(23)(24)(25). The VOI was defined as the tumor (2,8,(17)(18)(19)(20)(21)(22)(23) or tumor plus metastatic lymph nodes (LNs) (15,16,24,25). Three threshold methods were adapted to segment VOIs.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Three threshold methods were adapted to segment VOIs. A fixed SUV of 2.5 (2,8,(15)(16)(17)(18)(19)22) or 3.0 (23) was used in 9 studies. The gradient segmentation method was applied in 1 study (20), and a percentage of SUVmax (30%, 42%, or 50%) was used in 3 studies (21,24,25).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In each study, patients were divided into 2 groups (high and low volume) based on cutoff values. A minimum P value was used in 4 studies (15,16,19,22), receiveroperating characteristics (ROCs) in 4 studies (2,7,23,24), and median value in 5 studies (16,18,20,21,23). High volumetric parameters were significant variables in predicting a worse prognosis except in 1 study (20).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…HNCs are histologically identical but clinically heterogeneous entities that show disparities in natural course or clinical behavior based on primary location (2). The American Joint Committee on Cancer staging is generally used to estimate the prognosis and guide therapy.…”

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confidence: 99%

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Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis

et al. 2014

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We conducted a comprehensive systematic review of the literature on volumetric parameters and a meta-analysis of the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with head and neck cancer (HNC). Methods: A systematic search of MEDLINE and EMBASE was performed using the key words PET, head and neck, and volume. Inclusion criteria were 18 F-FDG PET used as an initial imaging tool; studies limited to HNC; patients who had not undergone surgery, chemotherapy, or radiotherapy before PET scans; and studies reporting survival data. Event-free survival and overall survival were considered markers of outcome. The impact of MTV or TLG on survival was measured by the effect size hazard ratio (HR). Data from each study were analyzed using Review Manager. Results: Thirteen studies comprising 1,180 patients were included in this study. The combined HR for adverse events was 3.06 (2.33-4.01, P , 0.00001) with MTV and 3.10 (2.27-4.24, P , 0.00001) with TLG, meaning that tumors with high volumetric parameters were associated with progression or recurrence. Regarding overall survival, the pooled HR was 3.51 (2.62-4.72, P , 0.00001) with MTV and 3.14 (2.24-4.40, P , 0.00001) with TLG. There was no evidence of significant statistical heterogeneity at an I 2 of 0%. Conclusion: MTV and TLG are prognostic predictors of outcome in patients with HNC. Despite clinically heterogeneous HNC and the various methods adopted between studies, we can confirm that patients with a high MTV or TLG have a higher risk of adverse events or death.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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confidence: 99%

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Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis

et al. 2014

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“…MTV 2.5 was still analyzed as significant determinant in predicting disease-free survival in resected pancreatic cancer (Table 4, and Figure 3). There have been several studies evaluating the oncologic significance of MTV 2.5 and TLG in lung cancer, 33 head and neck cancer, 34,35 esophageal cancer, 36 ovarian cancer, 37 osteosarcoma, 38 and colorectal cancer. 39,40 Several previous studies have showed the efficacy of MTV2.5 in predicting oncologic outcomes in various cancers.…”

Section: Discussionmentioning

confidence: 99%

Preoperative volume-based PET parameter MTV2.5 as a potential surrogate marker for tumor biology and recurrence in resected pancreatic cancer

et al. 2014

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Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy

et al. 2014

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It is not well established whether pretreatment 18F-FDG PET/CT can predict local response of head and neck squamous cell carcinoma (HNSCC) to chemoradiotherapy (CRT). We examined 118 patients: 11 with nasopharyngeal cancer (NPC), 30 with oropharyngeal cancer (OPC), and 77 with laryngohypopharyngeal cancer (LHC) who had completed CRT. PET/CT parameters of primary tumor, including metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum and mean standardized uptake value (SUVmax and SUVmean), were correlated with local response, according to primary site and human papillomavirus (HPV) status. Receiver-operating characteristic analyses were made to access predictive values of the PET/CT parameters, while logistic regression analyses were used to identify independent predictors. Area under the curve (AUC) of the PET/CT parameters ranged from 0.53 to 0.63 in NPC and from 0.50 to 0.54 in OPC. HPV-negative OPC showed AUC ranging from 0.51 to 0.58, while all of HPV-positive OPCs showed complete response. In contrast, AUC ranged from 0.71 to 0.90 in LHC. Moreover, AUCs of MTV and TLG were significantly higher than those of SUVmax and SUVmean (P < 0.01). After multivariate analysis, high MTV >25.0 mL and high TLG >144.8 g remained as independent, significant predictors of incomplete response compared with low MTV (odds ratio [OR], 13.4; 95% confidence interval [CI], 2.5–72.9; P = 0.003) and low TLG (OR, 12.8; 95% CI, 2.4–67.9; P = 0.003), respectively. In conclusion, predictive efficacy of pretreatment 18F-FDG PET/CT varies with different primary sites and chosen parameters. Local response of LHC is highly predictable by volume-based PET/CT parameters.

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Prognostic value of metabolic tumor volume measured by 18F-FDG PET/CT in advanced-stage squamous cell carcinoma of the larynx and hypopharynx

Abstract: Pretreatment MTV is an independent prognostic factor in patients with locoregionally advanced squamous cell carcinoma of the larynx and hypopharynx.

Cited by 77 publications

References 27 publications

Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis

Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis

Preoperative volume-based PET parameter MTV2.5 as a potential surrogate marker for tumor biology and recurrence in resected pancreatic cancer

Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy

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