Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis

Abstract

Background. Some studies showed that microRNA-497 (miR-497) might act as a prognostic biomarker of cancer. However, the conclusion was not consistent. The aim of this study was to investigate the prognostic role of miR-497 in various carcinomas. Methods. We systematically searched the databases of PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Data to identify relevant studies. Two independent reviewers performed the data extraction and assessed the study quality. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for overall survival (OS) and disease-free survival/relapse-free survival (DFS/RFS) were used to assess the associations between miR-497 expression and cancer prognosis. Results. A total of 15 studies involving 1760 participants fulfilled the inclusion criteria. The lower level of miR-497 expression was significantly associated with shorter overall survival (HR=2.19, 95% CI: 1.84-2.60). No significant association was found between miR-497 expression and DFS/RFS in various carcinomas (HR=1.17, 95% CI: 0.53-2.57). Subgroup analyses by ethnicity and cancer type showed the consistent results. Conclusion. Our studies suggested that miR-497 might be a prognostic biomarker in cancers. However, further multicenter prospective clinical researches are needed to confirm the association between miR-497 expression and cancer prognosis.

Extracellular vesicle‐derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR‐497/septin 2 pathway

“…The downregulation of miR‐497 expression in PCa is consistent with its function in most tumours (Liu et al, 2019). Wang et al (2013) found that miR‐497 inhibited cell growth and induced apoptosis by activating caspase‐3 in PCa cells.…”

“…The sequence analysis of circ_SLC19A1 showed that it contained multiple binding sites for miR‐497. Studies have found that miR‐497 expression in many kinds of tumours is decreased, which can inhibit the occurrence and development of tumours (Liu et al, 2019). In addition, downstream target genes of miR‐497 were predicted, and septin 2 (SEPT2) was one the potential important target genes.…”

Regulation of microRNA‑497 expression in human cancer (Review)

“…In 2018, a meta-analysis of 12 studies (including a total of 989 cancer patients) revealed that tumor patients with a high level of miR-497 expression exhibited longer OS times ( 144 ). In 2019, a meta-analysis of 15 studies (including a total of 1,760 participants) revealed that lower miR-497 expression levels were significantly correlated with shorter OS time, but not disease-free survival or relapse-free survival, indicating that miR-497 was not significantly correlated with early prediction, but may be of value as a biomarker of long-term prognosis ( 145 ).…”

The Role of Circulating CD16+CD56+ Natural Killer Cells in the Screening, Diagnosis, and Staging of Colorectal Cancer before Initial Treatment

“…There have been reports of the prognosis of CRC based on immunohistochemistry staining to detect gene mutation or polymorphism [28, 29], or activation [30], which is only feasible after surgical procedures. One category of circulating biomarkers for CRC falls within the scope of gene regulation (microRNA or methylation) [31, 32]. Another category resides in serum metabolomics analysis [33].…”