Prognostic value of microRNAs in osteosarcoma: a meta-analysis

Kim, Yun Hak; Goh, Tae Sik; Lee, Chi‐Seung; Oh, Sae Ock; Kim, Jeung Il; Jeung, Seung Hyeon; Pak, Kyoungjune

doi:10.18632/oncotarget.14429

Cited by 43 publications

(38 citation statements)

References 45 publications

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“…8 MiRNA are frequently located in the genomic regions involved in cancer, indicating the critical role of miRNAs in carcinogenesis including cancer progression. 9 MiRNAs are dysregulated in most of human cancers, including GBM, 10 gastric cancer, 11 osteosarcoma, 12 tongue squamous cell carcinoma, 13 and breast cancer. 14 Some miRNAs are aberrantly expressed in GBM, including miR-143, 15 miR-204, 16 miR-574, 17 and miR-744.…”

Section: Introductionmentioning

confidence: 99%

<p>MicroRNA-559 plays an inhibitory role in the malignant progression of glioblastoma cells by directly targeting metadherin</p>

Yang¹,

Zhang²,

Xu³

et al. 2019

OTT

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Purpose: Several microRNAs (miRNAs) that are aberrantly expressed in glioblastoma multiforme (GBM) play a significant role in GBM formation and progression. The expression profile and functions of miR-559 in GBM remain unclear. Here, we quantified the expression and investigated the involvement of miR-559 in the oncogenicity of GBM cells in vitro and in vivo. Material and methods: Reverse-transcription quantitative polymerase chain reaction (RT-qPCR) was carried out to determine miR-559 expression in GBM tissues and cell lines. A series of functional assays was performed to evaluate the effects of miR-559 overexpression on GBM cell proliferation, apoptosis, migration, and invasion in vitro and on GBM tumor growth in vivo. The regulatory mechanisms of miR-559 action in GBM cells were then explored. Results: The expression of miR‑559 was lower in GBM tissues and cell lines and significantly correlated with the Karnofsky performance score and tumor size among patients with GBM. Exogenous miR‑559 expression inhibited GBM cell proliferation, migration, and invasion and promoted apoptosis. MiR-559 overexpression decreased tumor growth in vivo. Mechanistic experiments confirmed metadherin ( MTDH ) as a direct target gene of miR-559 in GBM. Silencing of MTDH induced effects similar to those of miR-559 upregulation in GBM cells, whereas MTDH expression restoration attenuated the antitumor effects of miR‑559 in GBM cells. Protein kinase B (AKT) in the phosphatase and tensin homolog (PTEN)–AKT signaling pathway was found to be deactivated in GBM cells after upregulation of miR-559 both in vitro and in vivo. Conclusion: MiR-559 acts as a tumor suppressor in GBM cells in vitro and in vivo, at least in part through the downregulation of MTDH and inhibition of AKT in the PTEN–AKT pathway. Therefore, targeting the miR-559–MTDH axis may be a promising therapeutic strategy for patients with GBM.

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Section: Introductionmentioning

confidence: 99%

<p>MicroRNA-559 plays an inhibitory role in the malignant progression of glioblastoma cells by directly targeting metadherin</p>

Yang¹,

Zhang²,

Xu³

et al. 2019

OTT

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“…Accumulating evidence have revealed that miRNAs regulate many oncogenes and tumour suppressors in cells, and lead to initiation and progression of cancer. 21 Recent years, several miRNAs have been identified as key regulators of OS progression and excellent predictors for clinical outcome of OS patients 22,23 Decreased expression of miR-876-5p has been observed in HNSCC, HCC, ESCC and lung cancer. 14,15 Moreover, miR-876-5p underexpression is associated with poor prognostic features and reduced survival of HCC patients.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐876‐5p inhibits cell proliferation, migration and invasion by targeting c‐Met in osteosarcoma

Xie

Xiao

Wang

et al. 2019

J Cellular Molecular Medi

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Recently, aberrant expression of miR‐876‐5p has been reported to participate in the progression of several human cancers. However, the expression and function of miR‐876‐5p in osteosarcoma (OS) are still unknown. Here, we found that the expression of miR‐876‐5p was significantly down‐regulated in OS tissues compared to para‐cancerous tissues. Clinical association analysis indicated that underexpression of miR‐876‐5p was positively correlated with advanced clinical stage and poor differentiation. More importantly, OS patients with low miR‐876‐5p level had a significant shorter overall survival compared to miR‐876‐5p high‐expressing patients. In addition, gain‐ and loss‐of‐function experiments demonstrated that miR‐876‐5p restoration suppressed whereas miR‐876‐5p knockdown promoted cell proliferation, migration and invasion in both U2OS and MG63 cells. In vivo studies revealed that miR‐876‐5p overexpression inhibited tumour growth of OS in mice. Mechanistically, miR‐876‐5p reduced c‐Met abundance in OS cells and inversely correlated c‐Met expression in OS tissues. Herein, c‐Met was recognized as a direct target of miR‐876‐5p using luciferase reporter assay. Notably, c‐Met restoration rescued miR‐876‐5p attenuated the proliferation, migration and invasion of OS cells. In conclusion, these findings indicate that miR‐876‐5p may be used as a potential therapeutic target and promising biomarker for the diagnosis and prognosis of OS.

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“…The secondary endpoint was event-free survival (EFS). Data regarding disease-free survival (DFS), progressfree survival (PFS), recurrence-free survival (RFS) were obtained from articles, and were redefined as EFS, which was measured from the date of initiation of therapy to the date of recurrence or metastasis [42,43].…”

Section: Data Extractionmentioning

confidence: 99%

Prognostic value of abnormally expressed long non-coding RNAs in patients with osteosarcoma: a meta-analysis

Wu¹,

Shi²,

Mu³

et al. 2018

Oncotarget

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Prognostic value of microRNAs in osteosarcoma: a meta-analysis

Cited by 43 publications

References 45 publications

<p>MicroRNA-559 plays an inhibitory role in the malignant progression of glioblastoma cells by directly targeting metadherin</p>

<p>MicroRNA-559 plays an inhibitory role in the malignant progression of glioblastoma cells by directly targeting metadherin</p>

MicroRNA‐876‐5p inhibits cell proliferation, migration and invasion by targeting c‐Met in osteosarcoma

Prognostic value of abnormally expressed long non-coding RNAs in patients with osteosarcoma: a meta-analysis

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