Prognostic value of microvessel density in esophageal squamous cell carcinoma-a systematic review and meta-analysis

Guo, Xinxin; Meng, Xingchen; Liu, Ran

doi:10.1016/j.prp.2021.153644

Cited by 6 publications

(4 citation statements)

References 44 publications

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“…Heterogeneity between studies was assessed using the inconsistency index I 2 statistic and its P -value assessment. According to the Cochrane Manual for Systematic Evaluation of Interventions, an I 2 value > 50% indicates signi cant heterogeneity between studies [14] . The quality of each included study was assessed using the ROB 2.0 tool of the Cochrane Collaboration Network, and sensitivity analyses were performed for all included studies by constructing funnel plots as well as subgroup analyses in order to assess the heterogeneity of effects of the different PAM drugs [15] .…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the risk of adverse cardiovascular events in patients with cancer treated with inhibitors of the PI3K/AKT/mTOR signaling pathway

Liang,

Zhang,

Tang

et al. 2024

Preprint

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Background: With the increasing of PI3K/AKT/mTOR (PAM) inhibitors in cancer therapy, there is a growing need to understand the incidence of cardiovascular events (CVAEs) associated with PAM inhibitors. Methods: A systematic search of all randomized clinical trials (RCTs) containing at least one PAM group in electronic databases such as PubMed, ClinicalTrials.gov registry, Embase, Medline, Cochrane Library, and major conferences was performed to extract available CVAEs. The cut-off date was January 31, 2024. Study heterogeneity was assessed using the I2 statistic. The risk of CVAEs associated with PAM inhibitors was calculated using Peto OR. Main outcomes and measures: The primary outcome was the incidence (95% CI) of PAM inhibitors cardiovascular adverse events in the total population and subgroups. The secondary outcome was the pooled risk of different CVAEs associated with PAM inhibitor exposure in the RCTs. Results: 33 unique RCTs (n=12,351) were included. The incidence of PAM inhibitors CVAEs of any grade in the intervention group was 48.2%, yielding a combined OR of 2.52 (95% CI, 1.82 - 3.49). The incidence of severe adverse cardiovascular events (≥ grade 3) in the intervention group was estimated at 7.1%, yielding a combined Peto OR of 1.41 (95% CI,1.04 - 1.93). PAM inhibitors were associated with an increased risk of 5 CVAEs including peripheral edema, lymphoedema, hypercholesterolemia, hypertriglyceridaemia and hyperlipidemia, with higher risks for hypercholesterolemia (Peto OR:3.27,95% CI:2.61-4.11, P<0.01; I2 = 55.5%，P=0.06) and hyperlipidemia (Peto OR:3.53. 95%CI:1.70-7.32, P<0.01; I2 = 19.3%，P=0.29). Conclusion: This study identified an overall incidence of PAM inhibitors CVAEs and the increased risks associated with PAM inhibitor for five specific CVAEs, not confined to hypercholesterolemia and peripheral edema.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of the risk of adverse cardiovascular events in patients with cancer treated with inhibitors of the PI3K/AKT/mTOR signaling pathway

Liang,

Zhang,

Tang

et al. 2024

Preprint

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“…Angiogenesis is known as a hallmark of tumors and key promoter of tumor growth and recurrence and the resultant tumor microenvironment (TME) contribute to diminished efficacy of chemotherapy, radiotherapy, and immunotherapy while facilitating cancer progression 6 . Our previous meta‐analysis also revealed a significant correlation between high microvessel density and poor clinicopathological criteria as well as reduced survival rates in patients with ESCC 8 . Therefore, further exploration into the molecular mechanism of tumor angiogenesis in TME is needed and normalization of the tumor vasculature may offer a novel therapeutic strategy for ESCC.…”

Section: Introductionmentioning

confidence: 89%

“… 6 Our previous meta‐analysis also revealed a significant correlation between high microvessel density and poor clinicopathological criteria as well as reduced survival rates in patients with ESCC. 8 Therefore, further exploration into the molecular mechanism of tumor angiogenesis in TME is needed and normalization of the tumor vasculature may offer a novel therapeutic strategy for ESCC.…”

Section: Introductionmentioning

confidence: 99%

Extracellular shuttling miR‐21 contributes to esophageal cancers and human umbilical vein endothelial cell communication in the tumor microenvironment and promotes tumor angiogenesis by targeting phosphatase and tensinhomolog

Zheng,

Liao,

Sun

et al. 2023

Thoracic Cancer

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BackgroundCell‐cell communication by carcinoma‐derived exosomes can influence the tumor microenvironment (TME) and regulate cancer progression. Based on the overexpression of microRNA‐21‐5p (miR‐21) in plasma from patients diagnosed with esophageal squamous cell carcinoma (ESCC) and exosomes from ESCC cell lines identified earlier, this study aimed to explore the influence of exosomal miR‐21 within the TME.MethodScRNA‐Seq and Bulk RNA‐Seq were integrated to elucidate the communication between cancer and endothelial cells. The functionality and mechanisms by which exo‐miR‐21 derived from carcinoma regulate endothelial cell‐mediated angiogenesis were assessed using a cocultivation model of EC9706 cells and recipient human umbilical vein endothelial cells (HUVECs), through blood vessel formation experiments, luciferase reporter assays, RT‐qPCR, and western blot analysis.ResultA total of 3842 endothelial cells were extracted from the scRNA‐seq data of ESCC samples and reclustered into five cell subtype. Cell‐cell communication analysis revealed cancer cells presented a strong interaction with angiogenesis‐like endothelial cells in secreted signaling. MiR‐21 was unregulated in ESCC and the carcinoma‐derived exo‐miR‐21 was significantly raised in HUVECs. The exo‐miR‐21 promoted the proliferation and migration of HUVECs while also enhancing, closed mesh count, and junction number in HUVECs. Mechanistically, dual‐luciferase reporter assay revealed that PTEN was the target of miR‐21. Meanwhile, p‐Akt was significantly increased and suppressed by inhibition of miR‐21 and PI3K inhibitor LY294002.ConclusionExo‐miR‐21‐mediated communication between endothelial and cancer cells plays a pivotal role in promoting the angiogenesis of ESCC. Therefore, controlling exo‐miR‐21 could serve as a novel therapeutic strategy for ESCC by targeting angiogenesis.

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“…Over the past decade, analyzed by immunohistochemistry, the state of angiogenesis has become a prognostic and predictive biological factor in the staging in human solid malignancies [ 18 ]. Mean microvessel density (MVD) has been tested in many human malignancy histological types, resulting as a powerful, even if often independent, prognostic indicator [ 19 , 20 , 21 ]. In addition, a significant association between one of the main regulators of angiogenesis, vascular endothelial growth factor (VEGF) expression, and prognosis has been reported [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic, Prognostic, and Therapeutic Role for Angiogenesis Markers in Head and Neck Squamous Cell Carcinoma: A Narrative Review

Alessandrini

Astolfi

Daloiso

et al. 2023

IJMS

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Despite refinements to diagnostic and therapeutic approaches over the last two decades, the outcome of patients with head and neck squamous cell carcinoma (HNSCC) has not shown substantial improvements, especially regarding those with advanced-stage disease. Angiogenesis is believed to be a turning point in the development of solid tumors, being a premise for mass growth and potential distant dissemination. Cancer-induced angiogenesis is a result of increased expression of angiogenic factors, decreased expression of anti-angiogenic factors, or a combination of both. The assessment of angiogenesis has also emerged as a potentially useful biological prognostic and predictive factor in HNSCC. The aim of this review is to assess the level of current knowledge on the neo-angiogenesis markers involved in the biology, behavior, and prognosis of HNSCC. A search (between 1 January 2012 and 10 October 2022) was run in PubMed, Scopus, and Web of Science electronic databases. After full-text screening and application of inclusion/exclusion criteria, 84 articles are included. The current knowledge and debate on angiogenesis in HNSCC presented in the eligible articles are stratified as follows: (i) diagnostic markers; (ii) prognostic markers; (iii) predictive markers; and (iv) markers with a potential therapeutic role. Angiogenesis is a biological and pathological indicator of malignancies progression and has negative implications in prognosis of some solid tumors; several signals capable of tripping the “angiogenic switch” have also been identified in HNSCC. Although several studies suggested that antiangiogenic agents might be a valuable adjunct to conventional chemo-radiation of HNSCC, their long-term therapeutic value remains uncertain. Further investigations are required on combinations of antiangiogenic agents with conventional chemotherapeutic ones, immunotherapeutic and molecularly targeted agents in HNSCC. Additional data are necessary to pinpoint which patients could benefit most from these treatments.

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Prognostic value of microvessel density in esophageal squamous cell carcinoma-a systematic review and meta-analysis

Cited by 6 publications

References 44 publications

A meta-analysis of the risk of adverse cardiovascular events in patients with cancer treated with inhibitors of the PI3K/AKT/mTOR signaling pathway

A meta-analysis of the risk of adverse cardiovascular events in patients with cancer treated with inhibitors of the PI3K/AKT/mTOR signaling pathway

Extracellular shuttling miR‐21 contributes to esophageal cancers and human umbilical vein endothelial cell communication in the tumor microenvironment and promotes tumor angiogenesis by targeting phosphatase and tensinhomolog

Diagnostic, Prognostic, and Therapeutic Role for Angiogenesis Markers in Head and Neck Squamous Cell Carcinoma: A Narrative Review

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