Prognostic value of miR-26a and HMGA1 in urothelial bladder cancer

Lin, Rongkai; Shen, Wenhao; Zhi, yi; Zhou, Zhansong

doi:10.1016/j.biopha.2014.10.003

Cited by 17 publications

(10 citation statements)

References 25 publications

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“…In our study, we found that miR-26a was markedly down-regulated in ESCC compared with adjacent normal control, and that down-regulated miR-26a was significantly inversely correlated with lymph node metastasis and overall prognosis, which suggested its tumor-suppressing role in ESCC. Our results from clinical tissues were in agreement with previous reports (22)(23)(24) that found that reduced miR-26a was significantly associated with inferior overall prognosis and metastases in patients with cancer. It remains unknown why miR-26a was down-regulated in ESCC, and further study is warranted.…”

Section: Discussionsupporting

confidence: 93%

Down‐regulated miR‐26a promotes proliferation, migration, and invasion via negative regulation of MTDH in esophageal squamous cell carcinoma

et al. 2017

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Numerous studies have reported that the role played by miR-26a in cancer is controversial, but whether miR-26a regulates metadherin (MTDH) expression in esophageal squamous cell carcinoma (ESCC) is unclear. We performed this study to investigate the clinical relevance of miR-26a expression in ESCC. miR-26a was detected by using the hybridization method. To functionally analyze the role of miR-26a in ESCC cell lines, KYSE-450 and Eca109 cells were employed, whose endogenous miR-26a was artificially down- or up-regulated, respectively, by using lentiviral-based transfection. There was significant association between miR-26a expression and clinical stage ( = 0.049), lymph node metastasis ( = 0.023), tumor volume ( = 0.003), and poor overall prognosis ( = 0.026). miR-26a was able to suppress proliferation and migration of ESCC cells Moreover, we have confirmed that miR-26a can negatively regulate MTDH in ESCC cells by using luciferase reporter assay. In addition, to investigate the role miR-26a plays in cell proliferation, we nude mice were xenografted with ESCC cells whose miR-26a was stably down- and up-regulated. Together, our results show that miR-26a is capable of suppressing the proliferation and migration of ESCC cells negative regulation of MTDH. Moreover, miR-26a expression was clinically relevant in cancer progression and poor prognosis, which supports the idea that miR-26a acts as a tumor suppressor in ESCC.-Yang, C., Zheng, S., Liu, T., Liu, Q., Dai, F., Zhou, J., Chen, Y., Sheyhidin, I., Lu, X. Down-regulated miR-26a promotes proliferation, migration, and invasion negative regulation of MTDH in esophageal squamous cell carcinoma.

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Section: Discussionsupporting

confidence: 93%

Down‐regulated miR‐26a promotes proliferation, migration, and invasion via negative regulation of MTDH in esophageal squamous cell carcinoma

et al. 2017

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“…Conversely, low miR-100 31 , miR-387 25 , miR-31 32 , miR-141 33 , miR-205 33 , miR-101 34 , miR-26a 35 , miR-203 15 , miR-424 36 , miR-214 17, 24 , miR-29c* 37 , miR-27a 38 , miR-27b 38 , miR-203 15 , and miR-34a 39 expressions were correlated with unfavorable prognosis. The miR-200 20, 23, 26 , miR-224 21 , miR-29c 29 , miR-148b-3p 30 , miR-3187-3p 30 , miR-15b-5p 30 , miR-27a-3p 30 , and miR-30a-5p 30 expression did not show any significant association with survival outcomes (Table 2 and Fig.…”

Section: Resultsmentioning

confidence: 92%

“…In comparison, low miR-100 31 , miR-387 25 , miR-31 32 , miR-141 33 , miR-205 33 , miR-101 34 , miR-26a 35 , miR-203 15 , miR-424 36 , miR-214 17, 24 , miR-29c* 37 , miR-27a 38 , miR-27b 38 , miR-203 15 , and miR-34a 39 expressions were correlated with unfavorable prognosis (Table 2 and Fig. 2).…”

Section: Discussionmentioning

confidence: 93%

MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis

Xie

Chen

et al. 2017

Sci Rep

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The aim of this study was to systematically review articles that investigated the prognostic significance of different microRNAs in bladder cancer (BC). We systematically searched PubMed, Web of Science, and Embase to identify relevant studies until March 2016. After screening, 26 studies that involved 2753 patients were included. Results suggested that many miRs expression aberration may predict prognosis in patients with BC. There are six miRs (miR-21, miR-143, miR-155, miR-200, miR-214, and miR-222) were reported by at least two studies, and we performed meta-analysis in the corresponding studies. Accordingly, we found that high miR-21 expression was associated with poor overall survival [OS; hazard ratio (HR) = 3.94, 95% CI 2.08–7.44]. High miR-143 expression was associated with poor progression-free survival (PFS; HR = 3.78, 95% CI 1.61–8.89). High miR-155 expression was associated with poor PFS (HR = 8.10, 95% CI 2.92–22.48). High miR-222 expression was associated with poor OS (HR = 3.39, 95% CI 1.10–10.41). Meanwhile, low miR-214 expression was correlated with poor RFS(HR = 0.34, 95% CI 0.22–0.53). Our comprehensive systematic review concluded that microRNAs, particularly miR-21, miR-143, miR-155, miR-214, and miR-222, could serve as meticulous follow-up markers for early detection of progression or recurrence and even useful therapeutic targets for the treatment in patients with BC.

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“…Further study showed that miR-182 displayed a diurnal variation in the retina of mice, revealed its role in retina development and the regulation of mammalian circadian rhythm [69]. What’s more, miR-182 is demonstrated to function either as a tumor suppressor or an oncomir in various human cancers [12, 17, 70]. Our previous sequencing data have indicated that miR-182 is a differentially expressed miRNA with a 15.55-fold increase in the RE compared with the PE of dairy goats [30].…”

Section: Discussionmentioning

confidence: 99%

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

Zhang

Liu

et al. 2017

PLoS ONE

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Increasing evidence has shown that miRNAs play important roles in endometrium development during the menstrual cycle in humans and many other animals. Our previous data indicated that miR-182 levels increase 15.55-fold and pleiotrophin (PTN) levels decrease 20.97-fold in the receptive endometrium (RE, D15) compared with the pre-receptive endometrium (PE, D5) in dairy goats. The present study shows that miR-182 is widely expressed in different tissues of dairy goats and that its expression levels are regulated by E2 and P4 in endometrial epithelium cells (EECs). We confirmed that PTN is a target of miR-182 and that miR-182 regulates the protein levels of AKT, Bcl-2, FAS, MAPK, Caspase-3 and SP1 in EECs. Furthermore, miR-182 up-regulates or maintains the expression levels of osteopontin (OPN), cyclooxygenase-2 (COX-2) and prolactin receptor (PRLR) in EECs, suggesting that miR-182 is an important regulatory factor in the construction of endometrial receptivity in dairy goats. In conclusion, miR-182 participates in the development of endometrial receptivity by down-regulating PTN and affecting the expression of select apoptosis-related genes and increasing or maintaining the expression levels of OPN, COX-2 and PRLR in the EECs of dairy goats.

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Prognostic value of miR-26a and HMGA1 in urothelial bladder cancer

Cited by 17 publications

References 25 publications

Down‐regulated miR‐26a promotes proliferation, migration, and invasion via negative regulation of MTDH in esophageal squamous cell carcinoma

Down‐regulated miR‐26a promotes proliferation, migration, and invasion via negative regulation of MTDH in esophageal squamous cell carcinoma

MicroRNAs with prognostic significance in bladder cancer: a systematic review and meta-analysis

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

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