Prognostic value of mitochondrial aspartate aminotransferase in acute myocardial infarction

Annoni, Giorgio; Chirillo, R; Swannie, Douglas

doi:10.1016/s0009-9120(86)80033-9

Cited by 10 publications

(2 citation statements)

References 28 publications

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“…marked increments of ast are present in myocardial infarction, acute hepatitis or toxic liver damage. moderate increases are observed in patients with chronic hepatitis and infectious mononucleosis (22,27). the enzymatic activity of ast was increased (p>0.05) in the serum of patients with periodontal disease versus the healthy group.…”

Section: Discussionmentioning

confidence: 95%

Salivary and serum enzymes as diagnostic biomarkers in patients with periodontal disease

Miricescu¹,

Totan²,

Calenic³

et al. 2014

EDUJ

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periodontitis is a common oral affection characterized by inflammation, connective tissue breakdown and, finally, alveolar bone loss. one feature of the inflammatory process is the release of enzymes from different oral tissues. the general aim of the present study was to detect salivary and serum enzyme levels in patients with periodontitis. methodology: we included 20 patients with chronic periodontitis and 20 controls. unstimulated whole saliva and serum was used to detect the enzymes employing the kinetic method and an automatic analyzer. patients and healthy controls were investigated for plaque index (pi), bleeding index (gi) and probing depth (pd) (p<0.05). the following enzymes were analyzed: aspartate aminotransferase (ast), lactate dehydrogenase (ldh), alkaline phosphatase (alp) and gamaglutamil transferase (ggt). results: the saliva of patients with periodontal disease presented significantly decreased levels of ldh and alp. significantly increased levels of serum alp and ggt were observed in patients with periodontal disease. at the same time no statistical difference was found between controls and periodontitis patients for ast and ldh. also salivary levels for ggt were decreased, while for ast the levels were increased but the difference was not statistically significant. Conclusion: the activity of these enzymes in the saliva and serum of patients with periodontal disease may represent a useful tool in diagnosing, monitoring and treating chronic periodontitis.

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Section: Discussionmentioning

confidence: 95%

Salivary and serum enzymes as diagnostic biomarkers in patients with periodontal disease

Miricescu¹,

Totan²,

Calenic³

et al. 2014

EDUJ

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“…After the appearance of clinical symptoms, such as chest pain, c-AST and m-AST peak at 28 h and 52 h, respectively, and peak c-AST but not m-AST correlate with peak CK-MB values, indicating that c-AST also reflects the extent of myocardial tissue damage [77,78]. Annoni et al [79] demonstrated that serum m-AST and the ratio of m-AST/AST correctly classified 91.9% of 112 AMI patients as survivors or non-survivors.…”

Section: Acute Myocardial Infarctionmentioning

confidence: 99%

5. Aspartate aminotransferase and alanine aminotransferase

El-Khoury¹,

Wang²

2014

Diagnostic Enzymology

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A 59-year-old female presented to the headache center with complaints of recurring headaches over the past few months. She had not been sleeping well, her headaches were worsening, and she was experiencing frequent hot flashes. Laboratory studies were unremarkable except for an elevated aspartate aminotransferase (AST) value of 175 U/L. The patient drank alcohol occasionally and exercised frequently. The physician requested that the test be repeated in 2 weeks to confirm the abnormal result and instructed the patient to avoid alcohol use and strenuous exercise during that period. Repeat testing 2 weeks later showed an AST of 164 U/L along with the following results: hepatitis A total antibody, positive; hepatitis A IgM antibody, negative; hepatitis C antibody, negative; iron, 17.4 μmol/L; total iron binding capacity, 48 μmol/L; and transferrin saturation, 36%. The patient was known to have immunity to hepatitis B. The persistently elevated AST was suspected to be caused by certain medications that she was taking. Testing was repeated in another 2 weeks along with a hepatic function panel and showed the following results: activated partial thromboplastin time (APTT), 30.5 s; prothrombin time (PT), 10.8 s; γ-glutamyltransferase (GGT), 15 U/L; albumin, 42 g/L; total bilirubin, 5.

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Diagnostic application of mitochondrial enzymes and isoenzymes

Schmidt

1989

Clinica Chimica Acta

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Prognostic value of mitochondrial aspartate aminotransferase in acute myocardial infarction

Cited by 10 publications

References 28 publications

Salivary and serum enzymes as diagnostic biomarkers in patients with periodontal disease

Salivary and serum enzymes as diagnostic biomarkers in patients with periodontal disease

5. Aspartate aminotransferase and alanine aminotransferase

Diagnostic application of mitochondrial enzymes and isoenzymes

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