Prognostic value of modified-Gustave-Roussy Immunity Score in resectable proximal gastric cancer

Abstract

The prognostic evaluation of GRIm score has been confirmed in many tumor species. The purpose of this study is to clarify the value of GRIm score in the prognostic evaluation of patients with resectable proximal gastric cancer. A single center retrospective study was conducted in 174 patients with proximal gastric cancer who underwent radical total gastrectomy. An in-depth analysis was carried out to explore the prognostic differences between high and low GRIm, and the influencing factors of disease-free survival rates and overall survival rates were analyzed by Cox regression model and Kaplan–Meier method. A total of 174 patients were divided into two groups: 135 patients were marked in L-mGRIm and 39 patients in H-mGRIm groups respectively. The median OS of the H-mGRIm and L-mGRIm groups were 23.2 and 38.6 months, respectively. The median DFS of the H-mGRIm and L-mGRIm groups was 16.9 and 31.7 months, respectively. Both DFS and OS were significantly different between groups ( P = .000, P = .000). In multivariate analysis, ZPS (2 vs 0–1: HR 1.99 95% CI 1.05–3.76 P = .035), LDH (≥193 vs <193:HR 0.6; 95% CI 0.38–0.95 P = .028), mGRIm score (2–3 vs 0–1: HR 2.4; 95% CI 1.09–5.23 P = .029) was independent risk factors of OS. The age (>65 vs ≤65 years HR 0.63; 95% CI 0.4–0.95 P = .003), LDH (>193 U/L vs ≤193 U/L: HR 0.55; 95% CI 0.37–0.82 P = .004) and mGRIm score (2–3 vs 0–1: HR 4.74; 95% CI 2.24–9.9 P = .000) as an independent risk factor for DFS. mGRIm score is a novel, simple and effective index for prognosis evaluation of resectable cardiac cancer and can be used as a part of the risk stratification process.

Prognostic significance of lactate dehydrogenase and its impact on the outcomes of gastric cancer: a systematic review and meta-analysis

“…Three studies were excluded at that stage: one study reported data on oesophageal cancer and two studies did not report relevant outcomes. Finally, eighteen studies that investigated the prognostic significance of lactate dehydrogenase (LDH) in gastric cancer were included in this review (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31).…”