Prognostic value of myeloperoxidase in coronary artery disease: comparison of unstable and stable angina patients

Abstract

Elevated MPO levels among the ACS patients suggest that this marker may participate in plaque vulnerability and instability process, whereas higher CRP levels were predictive of cardiac events only among the stable angina patients. These findings suggest distinct role of the inflammatory markers studied in the pathophysiology of coronary artery disease.

Human Neutrophil Peptides Mediate Endothelial-Monocyte Interaction, Foam Cell Formation, and Platelet Activation

“…20,23 Furthermore, a significant correlation was revealed between HNP skin deposition and the severity of coronary artery diseases, as evaluated by the number of blood vessels associated with focal lesions and stenosis. 25 We demonstrated that HNPs may act not only as a biomarker like MPO to predict coronary diseases, as previously reported, 42 but also function as an effector to induce or deteriorate inflammatory cardiac events by inducing endothelium-monocyte interaction through increasing the conventional receptor-ligand interaction between ICAM-1 and CD11b, oxidative stress and foam cell formation. In a previous study, we also showed that the stimulation of HUVECs with HNPs dose-dependently increases COX-2 expression.…”

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

“…Similarly, Morrow et al reported elevated baseline MPO in patients presenting with non-ST elevation ACS to be associated with a higher risk of non-fatal MI or recurrent ACS within 30 days, and inclusion of MPO with B-type natriuretic peptide and cardiac troponin to improve short-term risk assessment and patient stratification [111]. Moreover, MPO was observed to be an independent predictor of MACEs in ACS patients during hospitalization [112].…”

“…Among patients with ACS, baseline MPO level was an independent predictor of major adverse cardiac events during hospitalization Not given [112] Tang et al…”

“…Studies supporting (References) Sample type MPO analysis method [109] Plasma ELISA [113] Plasma ELISA [111] Citrate plasma ELISA [117] EDTA plasma ELISA [112] [ 116] EDTA plasma Sandwich ELISA [89] Plasma ELISA [174] EDTA plasma Sandwich ELISA [114] Serum Latex enhanced Immunoturbidimetric Assay Studies contradicting [115] Heparin plasma ELISA Table 9. MPO is associated with future cardiovascular mortality.…”

Myeloperoxidase: New Roles for an Old Molecule

“…Roman et al (46) found that elevated MPO levels were higher in patients with ACS than in patients with stable angina. Also, among patients with ACS, an elevated MPO level (higher than the median value) at admission to the emergency was a predictor of cardiovascular events (death, recurrent angina, congestive heart failure, severe arrhythmia) during hospital stay (OR 2.95, 95% CI, 1.1-8.2).…”