Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis

The Neutrophil-to-Lymphocyte Ratio as a Biomarker in Cutaneous Oncology: A Systematic Review of Evidence beyond Malignant Melanoma

“…Specifically, an increased NLR in patients with cSCC is a proxy for the finding of advanced disease, indicating a potentially compromised course. The rather limited evidence presented herein, from four studies, is corroborated by a meta-analysis of seven retrospective studies that have addressed SSC in the epithelia of male external genitals [ 68 ]. Saputra et al, by employing the studies’ specific cut-off values for the NLR (ranging from 2.60 to 3.59) as a dichotomous predictor, revealed that a higher than cut-off NLR value is an independent predictor for the presence of lymph node metastases (OR = 6.67, 95%CI: 2.44–18.22; p < 0.01) and of shorter cancer-specific survival (HR = 2.15, 95%CI: 1.23–3.73; p < 0.01); however, not of the overall survival of the patient (HR = 1.69, 95%CI: 0.95–3.00, p = 0.07) [ 68 ].…”

“…The rather limited evidence presented herein, from four studies, is corroborated by a meta-analysis of seven retrospective studies that have addressed SSC in the epithelia of male external genitals [ 68 ]. Saputra et al, by employing the studies’ specific cut-off values for the NLR (ranging from 2.60 to 3.59) as a dichotomous predictor, revealed that a higher than cut-off NLR value is an independent predictor for the presence of lymph node metastases (OR = 6.67, 95%CI: 2.44–18.22; p < 0.01) and of shorter cancer-specific survival (HR = 2.15, 95%CI: 1.23–3.73; p < 0.01); however, not of the overall survival of the patient (HR = 1.69, 95%CI: 0.95–3.00, p = 0.07) [ 68 ]. Also, in a recent cohort study of 96 patients with penile SCC, a higher NLR was independently associated with shorter progression-free survival, while patients with an NLR > 3.0 were at higher risk of experiencing more advanced disease [ 69 ].…”

Inflammatory Biomarker Correlations and Prognosis in High-risk Gastrointestinal Stromal Tumor Patients: A Multicenter Retrospective Analysis

“…In managing high-risk GISTs, re ning risk factors within the modi ed NIH risk strati cation is essential, but it is equally important to incorporate additional factors, such as in ammatory markers, to guide treatment and prognostic assessments 26 . Recent studies have highlighted the role of the tumor microenvironment, particularly in ammatory reactions, in tumor cell migration and metastasis 18,27,28 . This is exempli ed by research in early gastric cancer, where patients with adenocarcinoma had higher NLRs and PLRs than did those with adenoma, and those with undifferentiated adenocarcinoma had higher NLRs than did those with differentiated forms 29 .…”

Trajectories of squamous cell carcinoma antigen and outcomes of patients with advanced penile cancer after chemotherapy based on paclitaxel, ifosfamid, and cisplatin regimen

“…Nevertheless, so far, no reliable biomarker has been identified to assist diagnosis and prognostic prediction in mainstream practice. Candidate markers include SCC‐A, C‐reactive protein (CRP), neutrophil‐to‐lymphocyte ratio, Ki‐67, human papillomavirus (HPV), P16INK4a, TP53, and programmed death‐ligand 1 (PD‐L1) 9,22–25 . Among those, SCC‐A is a sensitive marker and feasible to be tested though blood sample.…”