Prognostic Value of Nonalcoholic Fatty Liver Disease in Patients With Severe Aortic Stenosis Who Underwent Transcatheter Aortic Valve Implantation

Nabeta, T; Myagmardorj, Rinchyenkhand; Hirasawa, Kensuke; Singh, Gurpreet K; Kley, Frank van der; Weger, Arend de; Knuuti, Juhani; Bax, Jeroen J.; Marsan, Nina Ajmone; Delgado, Victoria

doi:10.1016/j.amjcard.2022.09.023

Cited by 3 publications

(2 citation statements)

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“…In a study with 538 patients who underwent CT before valve implantation, MASLD was defined as a liver‐to‐spleen attenuation ratio <1.0 on CT without contrast while hepatic fibrosis was assessed using the NFS. Based on a follow‐up period of 47 months, MASLD did not predict all‐cause mortality (HR: 1.32, 95 CI: 0.97–1.97), nor did the NFS (HR for NFS < −1.455 vs. >0.676 = 1.54, 95% CI: 0.82–2.91), 90 suggesting that the existence of liver fibrosis in MASLD should not withhold patients for undergoing TAVI. In contrast, another study with 480 participants reported that a FIB‐4 index with a cut‐off value of 1.82 predicts 1‐year all‐cause mortality in patients receiving a novel aortic valve via TAVI with an HR of 1.75 (95% CI: 1.18–2.59) after adjusting for most relevant confounders.…”

Section: Aortic Valve Sclerosis and Stenosismentioning

confidence: 94%

“…1.32, 95 CI: 0.97-1.97), nor did the NFS (HR for NFS < −1.455 vs. >0.676 = 1.54, 95% CI: 0.82-2.91), 90 suggesting that the existence of liver fibrosis in MASLD should not withhold patients for undergoing TAVI. In contrast, another study with 480 participants reported that a FIB-4 index with a cut-off value of 1.82 predicts 1-year all-cause mortality in patients receiving a novel aortic valve via TAVI with an HR of 1.75 (95% CI: 1.18-2.59) after adjusting for most relevant confounders.…”

Section: Aorti C Valve Scleros Is and S Tenos Ismentioning

confidence: 97%

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Liver stiffness as a cornerstone in heart disease risk assessment

Boeckmans,

Sandrin,

Knackstedt

et al. 2023

Liver International

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Metabolic dysfunction‐associated steatotic liver disease (MASLD) typically presents with hepatic fibrosis in advanced disease, resulting in increased liver stiffness. A subset of patients further develops liver cirrhosis and hepatocellular carcinoma. Cardiovascular disease is a common comorbidity in patients with MASLD and its prevalence is increasing in parallel. Recent evidence suggests that especially liver stiffness, whether or not existing against a background of MASLD, is associated with heart diseases. We conducted a narrative review on the role of liver stiffness in the prediction of highly prevalent heart diseases including heart failure, cardiac arrhythmias (in particular atrial fibrillation), coronary heart disease, and aortic valve sclerosis. Research papers were retrieved from major scientific databases (PubMed, Web of Science) until September 2023 using ‘liver stiffness’ and ‘liver fibrosis’ as keywords along with the latter cardiac conditions. Increased liver stiffness, determined by vibration‐controlled transient elastography or hepatic fibrosis as predicted by biomarker panels, are associated with a variety of cardiovascular diseases, including heart failure, atrial fibrillation, and coronary heart disease. Elevated liver stiffness in patients with metabolic liver disease should lead to considerations of cardiac workup including N‐terminal pro–B‐type natriuretic peptide/B‐type natriuretic peptide determination, electrocardiography, and coronary computed tomography angiography. In addition, patients with MASLD would benefit from heart disease case‐finding strategies in which liver stiffness measurements can play a key role. In conclusion, increased liver stiffness should be a trigger to consider a cardiac workup in metabolically compromised patients.

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Section: Aortic Valve Sclerosis and Stenosismentioning

confidence: 94%

Section: Aorti C Valve Scleros Is and S Tenos Ismentioning

confidence: 97%