Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress

Tomandlová, Marie; Jarkovský, Jiří; Tomandl, Josef; Kubková, Lenka; Kala, Petr; Littnerová, Simona; Gottwaldová, Jana; Kuběna, Petr; Ganovská, Eva; Poloczek, Martin; Špinar, Jindřich; Müeller, Christian; Mebazaa, Alexandre; Goldbergová, Monika Pávková; Pařenica, Jiří

doi:10.1155/2015/159051

Cited by 23 publications

(21 citation statements)

References 42 publications

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“…A study conducted by Marie Tomandlova et al in 2015 found that high levels of serum PTX3 can predict 1-year mortality of patients with STEMI; these patients are more likely to be afflicted with ventricular dysfunction after MI, causing their mortality to go higher and higher after 1 year [16]. However, both the nature and examined population of the present study differed hugely with their study.…”

Section: Discussioncontrasting

confidence: 62%

Investigating the Relationship Between Serum Pentraxin3 Level and Angiographic Findings in Patients With Coronary Angiography

Heybar

Assareh

Jalali

2018

Asian J Pharm Clin Res

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Objective: Pentraxin3 (PTX3) is an inflammatory single-phase mononuclear polysorbate glycoprotein, synthesized by endothelial, macrophages, and mildew cells; based on reports and research findings, it is also believed to be synthesized in the tissue of atherosclerotic lesions of arterial arteries. Therefore, PTX3 can be considered as a more specific marker for atherosclerosis. The present study examines the relationship between PTX3 serum levels and coronary angiography findings.Methods: A total of 100 patients with stable cardiac status under elective coronary angiography were studied. Meanwhile, serum levels of PTX3 were measured, along with coronary angiography, in these patients. Finally, the relationship between the serum level of this marker and the severity of the angiographic findings of these individuals was compared and contrasted.Results: out of 100 patients examined in the present study, 57 subjects (57.6%) were male and 42 subjects (42.4%) were female. The mean age of participants turned out to be 53±9.16, and the mean serum level of PTX3 was 5.91±12.5. The mean serum level of PTX3 turned out to be lower in patients with normal angiography than in those with coronary artery disease (p<0.0001). Smoking and age did not affect the mean serum levels of this marker. Furthermore, a higher serum level of PTX3 was associated with a higher syntax score in the angiography (p<0.0001).Conclusion: Serum levels of PTX3 can have a predictive value in the diagnosis of coronary artery disease in patients with stable cardiovascular symptoms.

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Section: Discussioncontrasting

confidence: 62%

Investigating the Relationship Between Serum Pentraxin3 Level and Angiographic Findings in Patients With Coronary Angiography

Heybar

Assareh

Jalali

2018

Asian J Pharm Clin Res

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“…Interestingly, PTX3 plasma levels might be a potentially useful biomarker to predict prognosis as well as to detect inflammatory status in patients with chronic heart failure, e.g. due to cardiac ischemia . The impact of this multifunctional molecule in infectious disease and also during sterile inflammation of the heart makes PTX3 an important regulator of inflammation.…”

Section: Introductionmentioning

confidence: 99%

The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3

et al. 2015

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Cardiomyocyte death as a result of viral infection is an excellent model for dissecting the inflammatory stress response that occurs in heart tissue. We reported earlier that a specific proteasome isoform, the immunoproteasome, prevents exacerbation of coxsackievirus B3 (CVB3)-induced myocardial destruction and preserves cell vitality in heart tissue inflammation. Following the aim to decipher molecular targets of immunoproteasome-dependent proteolysis, we investigated the function and regulation of the soluble PRR Pentraxin3 (PTX3). We show that the ablation of PTX3 in mice aggravated CVB3-triggered inflammatory injury of heart tissue, without having any significant effect on viral titers. Thus, there might be a role of PTX3 in preventing damageassociated molecular pattern-induced cell death. We found that the catalytic activity of the immunoproteasome subunit LMP7 regulates the timely availability of factors controlling PTX3 production. We report on immunoproteasome-dependent alteration of ERK1/2 and p38MAPKs, which were both found to be involved in PTX3 expression control. Our finding of a cardioprotective function of immunoproteasome-dependent PTX3 expression revealed a crucial mechanism of the stress-induced damage response in myocardial inflammation. In addition to antigen presentation and cytokine production, proteolysis by the immunoproteasome can also regulate the innate immune response during viral infection.Keywords: Infection r Inflammation r Innate immunity r Myocarditis r Pentraxin3 r Proteasome r Stress response r Virus Additional supporting information may be found in the online version of this article at the publisher's web-site IntroductionThe myocardium can be injured by various pathophysiological processes. Myocarditis is an excellent model of heart muscle Correspondence: Dr. Antje Voigt e-mail: antje.voigt@charite.de injury for dissecting processes of the heart stress response to inflammation. In developed countries, myocarditis most commonly results from a virus infection, often by coxsackievirus B3 (CVB3) and adenoviruses. Fulminant injury of the heart muscle in * These authors contributed equally to this work.C 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.eji-journal.eu 620Anna Paeschke et al. Eur. J. Immunol. 2016. 46: 619-633 viral myocarditis is attributed to both, direct virus-mediated cytotoxic effects and destruction of the heart muscle by the immune system [1,2]. The balance of intrinsic and innate immune mechanisms determines whether there is repair of the heart muscle or progression to chronic inflammation. This process involves the engagement of pattern recognition receptors (PRRs) either with pathogen-associated molecular patterns (PAMPs) such as viral RNA, or, upon the release of endogenous material, with damageassociated molecular patterns (DAMPs) [3]. Our knowledge on disease course in patients comes mainly from the mouse model of CVB3 myocarditis. Cardiotropic CVB3 infects mice and replicates to high titers, causing acute myocarditis (ACM) that faithfully mirrors...

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“…8,9) Appropriate prognostic risk stratification may help clinicians better manage patients by assessing mortality risk. Recent studies have been attempting to identify novel biomarkers such as ubiquitin, Gremlin-1, cyclophilin A, pentraxin-3, and heterogeneous nuclear ribonucleoprotein C. [10][11][12] In our study, we enrolled 287 subjects in order to explore the easily measured and complementary long-term prognostic factors ST2, NT-proBNP, and serum sodium in AHF patients receiving standard treatment according to the guideline. Our goals were to clarify the roles of these 3 variables as indicators of AHF prognosis and to investigate the specific cut-off level for risk stratification.…”

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confidence: 99%

Predictors of Long-Term Mortality in Patients With Acute Heart Failure

et al. 2017

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SummaryTo investigate parameters which were related with long-term mortality in patients hospitalized for acute heart failure (AHF).A total of 287 patients with AHF presenting to the First Affiliated Hospital of Nanjing Medical University were enrolled into the registry from April 2012 to January 2015. The primary endpoint was all-cause mortality within 1 year; the association between variables and prognosis was assessed after 1 year.Among the 287 patients, 17 did not continue follow-up and 47 (17.4%) passed away. Baseline NT-proBNP and sST2 concentrations were higher amongst deceased than among survivors (P < 0.001). Serum sodium concentrations of patients who died were lower (P < 0.001). In receiver operator characteristics (ROC) analyses, the area under the curve (AUC) values for NT-proBNP, sST2, and serum sodium to predict 1-year mortality were 0.699 (95%CI 0.639-0.755), 0.692, (95%CI 0.634-0.747), and 0.694 (95%CI 0.634-0.750), respectively. The optimal cut-off points for NT-proBNP, sST2, and serum sodium were 2137.0 ng/L, 35.711 ng/mL, and 136.6 mmol/L, respectively. In Cox regression analysis, ln-transformed NT-proBNP (HR 1.546, P = 0.039), ln-transformed sST2 (HR1.542, P = 0.049), and serum sodium (HR 0.880, P = 0.000) values reliably predicted long-term mortality after multivariable adjustment.In patients with acute heart failure, NT-proBNP, sST2 and serum sodium are potential predictors of 1-year mortality. (Int Heart J 2017; 58: 409-415)

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Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress

Cited by 23 publications

References 42 publications

Investigating the Relationship Between Serum Pentraxin3 Level and Angiographic Findings in Patients With Coronary Angiography

Investigating the Relationship Between Serum Pentraxin3 Level and Angiographic Findings in Patients With Coronary Angiography

The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3

Predictors of Long-Term Mortality in Patients With Acute Heart Failure

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