Prognostic value of pericoronary adipose tissue attenuation in patients with non-alcoholic fatty liver disease with suspected coronary artery disease

Ichikawa, Keishi; Miyoshi, Toru; Nakashima, Mitsuyoshi; Nishihara, Takahiro; Osawa, Kazuhiro; Miki, Takashi; Toda, H.; Yoshida, Midori; Ito, Hiroshi

doi:10.1007/s00380-022-02107-x

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Recently, pericoronary adipose tissue attenuation on CCTA was higher in patients with vs. without NAFLD, and patients with NAFLD with higher pericoronary adipose tissue attenuation had worse cardiovascular prognoses [ 101 , 102 ]. Pericoronary adipose tissue attenuation is a novel method for the risk assessment of cardiac mortality, reflecting pericoronary inflammation [ 103 ].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

et al. 2023

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Cardiovascular diseases and liver diseases are closely related. Non-alcoholic fatty liver disease has the same risk factors as those for atherosclerotic cardiovascular disease and may also be a risk factor for atherosclerotic cardiovascular disease on its own. Heart failure causes liver fibrosis, and liver fibrosis results in worsened cardiac preload and congestion. Although some previous reports regard the association between cardiovascular diseases and liver disease, the management strategy for liver disease in patients with cardiovascular diseases is not still established. This review summarized the association between cardiovascular diseases and liver disease. In patients with non-alcoholic fatty liver disease, the degree of liver fibrosis progresses with worsening cardiovascular prognosis. In patients with heart failure, liver fibrosis could be a prognostic marker. Liver stiffness assessed with shear wave elastography, the fibrosis-4 index, and non-alcoholic fatty liver disease fibrosis score is associated with both liver fibrosis in patients with liver diseases and worse prognosis in patients with heart failure. With the current population ageing, the importance of management for cardiovascular diseases and liver disease has been increasing. However, whether management and interventions for liver disease improve the prognosis of cardiovascular diseases has not been fully understood. Future investigations are needed.

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Section: Clinical Applicationsmentioning

confidence: 99%

Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

et al. 2023

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“…Recent landmark studies of PCAT attenuation have demonstrated that PCAT attenuation can not only detect biopsy-proven vascular inflammation ( 9 ) but can also be used as a noninvasive biomarker of vascular inflammation to assess CHD ( 12 ), adverse cardiac events ( 13 ), left ventricular function ( 14 ), and microvascular complications in patients with diabetes ( 15 ). In addition, high PCAT attenuation values detected using coronary computed tomographic angiography (CCTA) are related to endothelial dysfunction ( 16 ), oxidized HDL levels ( 17 ), cardiovascular events in patients with nonalcoholic fatty liver disease ( 18 ), and the recurrence of atrial fibrillation after ablation ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between different clinical characteristics and pericoronary adipose tissue attenuation values quantified from coronary computed tomographic angiography (CCTA) in patients without coronary heart disease (CHD)

Xu,

Jing,

Zhu

et al. 2024

Quant Imaging Med Surg

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Background Pericoronary adipose tissue (PCAT) is a sensor of vascular inflammation. Elevated PCAT attenuation values indicate the presence of coronary inflammation in patients. However, it is unclear which clinical characteristics are associated with increased PCAT attenuation values in patients without coronary heart disease (CHD). The study aims to investigate the relationship between increased PCAT attenuation values and clinical characteristics of patients without CHD. Methods We recruited 785 eligible patients without CHD who underwent coronary computed tomographic angiography (CCTA). Clinical data were recorded for each patient, and PCAT attenuation values for the left anterior descending branch (LAD PCAT ), left circumflex branch (LCX PCAT ), and right coronary artery (RCA PCAT ) were quantified by CCTA using fully automated software. Univariate and multivariate analyses were performed to identify the associations between different clinical characteristics and elevated LAD PCAT , LCX PCAT , and RCA PCAT . Results Univariate analysis showed body mass index (BMI) to be positively associated with LAD PCAT (rs=0.109), LCX PCAT (rs=0.076), and RCA PCAT (rs=0.083). Moreover, the duration of smoking, and drinking was positively associated with LAD PCAT (rs=0.099, 0.165). Hyperlipidemia was positively associated with LAD PCAT (rs=0.089) and RCA PCAT (rs=0.334), while statin use was negatively associated with RCA PCAT (rs=−0.145). Multivariate analysis showed that the significant determinants of LAD PCAT were BMI (β=0.359, P=0.001), duration of smoking (β=2.612, P=0.002), drinking (β=4.106, P<0.001), and hyperlipidemia (β=1.664, P=0.027). LCX PCAT was associated with BMI (β=0.218, P=0.024), while RCA PCAT was associated with hyperlipidemia (β=6.110, P<0.001) and statin use (β=−3.338, P<0.001). Conclusions In patients without CHD, the PCAT attenuation values measured using CCTA were associated with various clinical characteristics. LAD PCAT was associated with BMI, smoking duration, drinking, and hyperlipidemia. On the other hand, LCX PCAT was associated with BMI, while RCA PCAT was associated with hyperlipidemia and statin use.

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Prognostic value of pericoronary adipose tissue attenuation in patients with non-alcoholic fatty liver disease with suspected coronary artery disease

Cited by 2 publications

References 29 publications

Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

Relationship between different clinical characteristics and pericoronary adipose tissue attenuation values quantified from coronary computed tomographic angiography (CCTA) in patients without coronary heart disease (CHD)

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