Prognostic value of platelet and neutrophil to lymphocyte ratio in COPD patients

Elgazzar, Ahmed; Kamel, Mohammed Hussein; Elbahnasy, Ola Kamal Mohammad; Elnaggar, Marwa Elsayed

doi:10.1080/17476348.2019.1675517

Cited by 73 publications

(55 citation statements)

References 22 publications

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“…4,5 Besides, other studies have shown that platelet-lymphocyte ratio (PLR) is also an effective marker of inflammation in evaluating the severity of COPD patients. 6 However, studies also found that there was no difference between GOLD A-D groups and NLR as well as PLR. 7 Relevant studies have shown that the lung function is related to the production of platelets (PLT).…”

Section: Introductionmentioning

confidence: 98%

Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease

Huang¹,

Wang²,

Shen³

et al. 2021

COPD

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Background We aimed to investigate the association between red cell index (RCI) and the severity of Chronic Obstructive Pulmonary Disease (COPD), and compare predictive value of RCI, neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) for the severity of COPD. Methods A total of 207 participants were recruited (100 COPD patients and 107 healthy controls). COPD patients were divided into two groups according to the optimal cut-off value of RCI determined by the receiver operating characteristic (ROC) curve. Pearson’s correlation test, logistic regression analysis and other tests were performed. Results Compared with low RCI group, the forced expiration volume in 1 second (FEV 1 ) and FEV 1 in percent of the predicted value (FEV 1 %) in high RCI group were lower ( p = 0.016, p = 0.001). There was a negative correlation between RCI and FEV 1 % ( r = −0.302, p = 0.004), while no correlation between FEV 1 % and NLR as well as PLR were found. RCI showed higher predictive value than NLR and PLR for predicting Global Initiative for Chronic Obstructive Lung Disease classification (GOLD), with a cut-off value of 1.75 and area under the curve (AUC) of 0.729 ( p = 0.001). Multivariate logistic regression analysis proved that RCI was an independent factor for lung function in COPD patients (odds ratio [OR] = 4.27, 95% CI: 1.57–11.63, p = 0.004). Conclusion RCI is a novel biomarker that can better assess pulmonary function and severity of COPD than NLR and PLR. Higher RCI is related to deterioration of pulmonary function.

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Section: Introductionmentioning

confidence: 98%

Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease

Huang¹,

Wang²,

Shen³

et al. 2021

COPD

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“…Based on the literature, NLR and CRP are wellknown biomarkers for inflammation in patients with COPD (2,(11)(12)(13). In addition to CRP, albumin is a negative acute phase reactant showing inflammatory response and CAR positively correlates with severe inflammation and infection, especially in critically ill patients (12,17).…”

Section: Discussionmentioning

confidence: 99%

“…The prolongation of the P wave can be observed in patients undergoing coronary artery bypass surgery and suffering from hypertrophic cardiomyopathy, right atrial dilatation, atrial septal defect, hypertension, and COPD due to affected atrial tissue (10). The COPD has an inflammatory process, and several studies have suggested the C-reactive protein-to-albumin ratio (CAR), neutrophil-tolymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) as well-known biomarkers for the measurement of inflammation in patients with COPD (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Atrial electromechanical delay of patients with COPD in acute and stable periods

Perinçek

Avcı

Kahraman³

2021

ircmj

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Background: The increased level of the airway and systemic inflammation, worsened clinical symptoms, and impaired lung functions are regarded as the characteristics of chronic obstructive pulmonary disease (COPD). The COPD may cause right/left ventricle dysfunction, pulmonary hypertension, and cor pulmonale. Objectives: The current study aimed to assess atrial electromechanical delay (AEMD) and echocardiographic changes and their relationship with inflammatory markers in subjects suffering from COPD during acute and stable periods. Methods: This prospective study was carried out on a total of 45 patients (including 22 and 23 female and male participants, respectively) suffering from COPD exacerbation. The stable phase of the participants was considered the control group. The first and second echocardiography was conducted in the first 24 h and following 3 months, respectively. Conventional and Tissue Doppler Imaging was utilized for the evaluation of atrial conduction times and systolic-diastolic functions of the right-left heart. The inflammatory markers, including the c-reactive protein-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio, were also measured in this study. Results: In the stable period, there was a significant reduction in lateral/tricuspid, lateral/mitral, and septal AEMD. The evaluation of right ventricle basal, mid and vertical diameters, tricuspid annular plane systolic excursion, Amax tricuspid, tricuspid regurgitant velocity, systolic pulmonary arterial pressure, tricuspid annular systolic motion, left atrium diameter, left ventricle end-diastolic diameter, interventricular septum thickness, mitral early diastole/atrium systole ratio, systolic mitral motion, systolic septal motion, and heart rate showed significant differences after 3 months. In addition, there was a significant decrease in C-reactive protein, CAR, and NLR. Conclusion: In the stable period, a significant reduction was observed in AEMDs and there was an improvement in the systolic functions of the right-left heart. No correlation was observed between AEMDs and inflammatory markers.

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“…Previous studies showed that patients experiencing more acute exacerbations of COPD show increased NLR and PLR compared to groups without exacerbations. 23,37 It is possible that acute COPD exacerbation may have been more frequent in the high PLR, COPD group, ultimately influencing the prognosis of this group. Nevertheless, exacerbation frequency was not…”

Section: Discussionmentioning

confidence: 99%

<p>Impact of Combined Chronic Obstructive Pulmonary Disease Status and Systemic Inflammation on Outcome of Advanced NSCLC: Multicenter Retrospective Cohort Study</p>

Lim

Kang

Yeo

et al. 2020

COPD

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Background In patients with non-small cell lung cancer (NSCLC), both chronic obstructive pulmonary disease (COPD) and systemic inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), have significant association with prognosis. NLR and PLR also predict mortality in patients with COPD alone. A combination of the two parameters may be helpful in a more individualized approach for predicting prognosis in NSCLC. Methods Medical records of patients with stage IIIB and IV NSCLC from January 2012 to January 2018 in seven university hospitals were reviewed. Patients were categorized into four subgroups based on pulmonary function test results and cutoffs for NLR or PLR. Results A total of 277 patients were evaluated and categorized into non-COPD and COPD groups; 194 patients were in the non-COPD group and 83 patients were in the COPD group. The non-COPD group showed significantly longer overall survival (OS) compared with the COPD group (P = 0.019). Median survival was significantly different between high/low PLR groups (P < 0.001), between high/low NLR groups (P = 0.001), and between high/low c-reactive protein (CRP) groups (P < 0.001). PLR, NLR and CRP showed significant correlations with each other. PLR showed a significant negative linear correlation with FVC (absolute) (r = −0.149, P = 0.015), FVC (%) (r = −0.192, P = 0.002), DLCO (absolute) (r = −0.271, P < 0.001), DLCO (%) (r = −0.139, P = 0.032), and NLR (r = 0.718, P < 0.001). In the multivariate analysis, the high PLR, COPD sub-group showed significantly higher risk for mortality (HR 2.066 (1.175–3.633), P = 0.012) compared with the low-PLR non-COPD group. However, COPD-NLR subtype was not an independent predictor for OS. Conclusion A combination of COPD status and PLR may be a cost-effective and readily available prognostic marker in patients with advanced NSCLC.

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Prognostic value of platelet and neutrophil to lymphocyte ratio in COPD patients

Cited by 73 publications

References 22 publications

Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease

Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease

Atrial electromechanical delay of patients with COPD in acute and stable periods

<p>Impact of Combined Chronic Obstructive Pulmonary Disease Status and Systemic Inflammation on Outcome of Advanced NSCLC: Multicenter Retrospective Cohort Study</p>

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