Prognostic value of platelet indices after acute myocardial infarction treated with primary percutaneous coronary intervention

Rechciński, Tomasz; Jasińska, Aleksandra; Foryś, Jakub; Krzemińska‐Pakuła, Maria; Wierzbowska−Drabik, Karina; Plewka, Michał; Peruga, Jan Z.; Kasprzak, Jarosław D.

doi:10.5603/cj.2013.0134

Cited by 86 publications

(93 citation statements)

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“…Lately the introduction of platelet distribution width (PDW) as a predicting factor has been studied extensively in consideration of its greater reliability in comparison to MPV [3]. PDW was reported to have prognostic value in PCI-treated acute MI [4]. No relationship between PDW and the prevalence of coronary artery disease (CAD) was discovered; however, PDW was related to CAD severity in patients with acute coronary syndrome (ACS) [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Platelet distribution width predicts left ventricular dysfunction in patients with acute coronary syndromes treated with percutaneous coronary intervention

et al. 2017

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A b s t r a c t Background:The role of platelets in the pathophysiology of acute coronary syndromes (ACS) is undeniable, but precise relationships between platelet activity and treatment outcomes are a matter of continuant investigation. Among platelet indices, mean platelet volume (MPV) has proven to be a valuable predicting factor in cardiac patients. However, platelet distribution width (PDW) is reported to be a more specific marker of platelet reactivity. Thus, application of PDW in risk stratification of ACS treatment is an up-to-date subject of research. PDW values in the assessment of left ventricular (LV) function have not been previously studied. Aim:The aim of the study was to evaluate whether admission PDW can predict LV systolic function in patients with ACS treated with stent implantation.Methods: On-admission PDW was measured in 278 consecutive patients with diagnosis of ACS, who underwent stent(s) implantation. Echocardiogram with LV ejection fraction (LVEF) estimation was performed within 24 h of percutaneous coronary intervention. Additionally, patients were under one-year follow-up, and one-year all-cause mortality was assessed.Results: According to receiver-operating characteristics (ROC) analysis, a PDW value greater than 12.8 fL could predict LVEF ≤ 35% with sensitivity of 81% and specificity of 39% (AUC 0.614; p = 0.0177). Only a trend was noted in ROC for PDW and one-year mortality (AUC 0.608; p = 0.0815). Multivariate logistic regression analysis has shown that the PDW parameter correlates independently with both systolic heart failure with LVEF ≤ 35% (PDW cut-off: 12.8 fL, OR 2.8107, CI 1.1401-6.9293, p = 0.0248) and one-year mortality (PDW cut-off: 16 fL, OR 2.6750, CI 1.0190-7.0225, p = 0.0457).Conclusions: Admission PDW may serve as a simple and widely available predictor of impaired LV function in patients with ACS. Association between PDW and mortality needs to be confirmed in larger studies.

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Section: Introductionmentioning

confidence: 99%

Platelet distribution width predicts left ventricular dysfunction in patients with acute coronary syndromes treated with percutaneous coronary intervention

et al. 2017

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“…An increase in PLCR shows the presence platelet aggregates, micro erythrocytes and giant platelets. 18 Rechciński T et al in their study found that PDW and PLCR, can serve as useful prognostic factors for long-term mortality in patients after acute MI. PDW was found to be one of the independent risk factors of cardiac mortality, as well as of the occurrence of either death, recurrent MI or need for another revascularization procedure.…”

Section: Introductionmentioning

confidence: 99%

“…PDW was found to be one of the independent risk factors of cardiac mortality, as well as of the occurrence of either death, recurrent MI or need for another revascularization procedure. 18 Thus platelets indices are important simple effortless and cost effective tool that can be used and explored extensively especially in countries such as India for predicting the possibility of impending acute coronary events. Hence present study was undertaken to compare the platelet indices viz, MPV, platelet distribution width (PDW), platelet large cell ratio (PLCR) in UA patients and ST segment elevated myocardial infarction (STEMI) with healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Platelet volume indices in acute coronary syndrome - a case control study

2016

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“…The performance of PIs in diagnosis of various diseases was reported. Some researchers showed that PIs may be useful adjunctive inflammatory markers of malignant tumors (15), which could predict the patients with acute myocardial infarction (16) and be used to predict placental abruption (17). Nevertheless, contradictory results are sometimes observed on the clinical studies of PIs in other diseases (18,19).…”

Section: Discussionmentioning

confidence: 99%

Survey of Correlation Between Serum Transferrin Saturation and Platelet Indices in High School Female Students in the Northwest Iran

Rafieemehr¹,

Rafiee²,

Mahmoodi³

et al. 2017

Int J School Health

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Background: Platelet indices (PIs), including platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) are used to predict clinical outcomes in patients with various medical conditions. The current study aimed at evaluating the correlation between serum iron saturation (IS) and PIs among the female students living in the Northwest of Iran. Methods: The current cross sectional study included 254 high school female (HSF) students aged 15 to 18 years in Hamadan, Iran, from September to January 2016. After completion of a questionnaire, the hematological parameters were determined using standard methods. HSF afflicted with infections and acute hemorrhage, and the ones with malignancies and inflammatory diseases were excluded. The correlation between the serum levels of IS and PIs in the female residents of Northwest of Iran was evaluated using the Pearson correlation test.

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Prognostic value of platelet indices after acute myocardial infarction treated with primary percutaneous coronary intervention

Cited by 86 publications

References 20 publications

Platelet distribution width predicts left ventricular dysfunction in patients with acute coronary syndromes treated with percutaneous coronary intervention

Platelet distribution width predicts left ventricular dysfunction in patients with acute coronary syndromes treated with percutaneous coronary intervention

Platelet volume indices in acute coronary syndrome - a case control study

Survey of Correlation Between Serum Transferrin Saturation and Platelet Indices in High School Female Students in the Northwest Iran

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