Prognostic Value of Podoplanin in Various Tumors

Abstract

Background: The prognostic significance of podoplanin (PDPN) in tumor cells for cancer patients’ survival remains controversial. Therefore, we performed this meta-analysis to clarify the relationship between the podoplanin-positive tumor cells and cancer prognosis. Method: Eligible studies were identified by searching the Pubmed and EBSCO online databases up to August 2019. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the correlation between podoplanin expression and overall survival (OS) and/or disease-free survival (DFS) and odds ratios (ORs) with 95% CIs severed as the summarized statistics for clinicopathological characteristic. Results: A total of 2155 patients from 21 eligible studies were included. The results revealed that high expression of podoplanin was associated with a poor survival rate in cancer patients. Further subgroup analysis stratified by tumor type showed that podoplanin-positive tumor cell infiltration had a negative prognostic effect associated with survival in esophageal cancer and oropharyngeal cancer. In addition, high expression of these cells was significantly associated with N stage, T stage, TNM stage and vascular invasion. Conclusion: Our study suggests the over-expression of podoplanin might be a significant prognostic indicator for patients with esophageal and oropharyngeal cancer.

Podoplanin expression in salivary gland carcinomas and its clinical significance. An immunohistochemical study

“…There was no significant difference between the high and low podoplanin expression with respect to age at diagnosis, gender, and tumour site. This is matched with the results of Wang et al [36].…”

“…High expression relation between TNM stage and poor N stage with podoplanin expression in tumour cells is in accordance with the results of Wang et al [36] in their meta-analysis on the prognostic value of podoplanin expression in various tumours. This observation stressed the critical role of podoplanin in tumourigenesis by induction of lymphangiogenesis and lymphatic dissemination of the tumour cells.…”

The Density of Renal Lymphatics Correlates With Clinical Outcomes in IgA Nephropathy

“…Clone D2-40 recognize podoplanin in normal and neoplastic tissues, and it has been used for the identification of lymphatic invasion in a variety of cancers. (10)(11) Lymphatic vessels were counted only in the cortex, and their areas were measured, using an Olympus Cell B Basic Imaging Software and the Olympus SC50 camera attached to an BX51 microscope. Lymphatic areas were defined as vascular areas delineated by D2-40 positive staining.…”

Expression Profile of Microenvironmental Factors in the Interface Zone of Colorectal Cancer: Histological-Stromal Biomarkers and Cancer Cell-Cancer-Associated Fibroblast-Related Proteins Combined for the Assessment of Tumor Progression

“…It is not specific to fibroblasts; it is also expressed in inflammatory macrophages and sometimes in epithelial tumor cells [10]. The expression of podoplanin in epithelial cancers by different cells has been reported more commonly at the invasive front [12][13][14] and has been associated with an immunosuppressive microenvironment, remodeling of the extracellular matrix [11], and higher carcinoma cell migration and invasion [15].…”

“…CRC studies have used these stromal markers to predict tumor characteristics and patient evolution, demonstrating that they somehow play a role in the neoplastic progression of CRC [16]. However, the findings in CRC patients remain unclear, with stromal features and the expression pattern of cancer-CAFrelated proteins, as well as their significance, differing between studies [12,15,[17][18][19]. In this study, we investigated the activity pattern of the elements that collectively make up the TME of CRC and their associations with neoplastic progression features, observing them, in a particular approach, in different interface zones of the tumor mass.…”