Prognostic value of preoperative anti‐thyroglobulin antibody in differentiated thyroid cancer

Jo, Kwanhoon; Kim, Min Hee; Ha, Jeonghoon; Lim, Yejee; Lee, Sohee; Bae, Ja Seong; Jung, Chan Kwon; Kang, Moo Il; Yun, Bong; Lim, Dong Jun

doi:10.1111/cen.13367

Cited by 22 publications

(20 citation statements)

References 36 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may indicate that autoimmunity is more powerfully manifested when both serum markers and target organ damage are present. Our finding that preoperative TgAb positivity had no significant influence in this regard is consistent with previous finding which may further indicate that the TPOAb status is more closely related to CLT than TgAb.…”

Section: Discussionsupporting

confidence: 92%

“…Jo et al . previously compared the disease persistence/recurrence in accordance with the preoperative TgAb status in patients with DTC but found no significant differences . Despite the fact that TPOAb and TgAb have similar immunologic properties, TPOAb is considered to be superior in predicting thyroid autoimmunity and detecting CLT than TgAb .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The value of preoperative antithyroidperoxidase antibody as a novel predictor of recurrence in papillary thyroid carcinoma

Song

Jeon

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

The link between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is widely recognized. Considering the strong association between raised antithyroidperoxidase antibody (TPOAb) and CLT, we postulated that the preoperative TPOAb can predict the prognosis of PTC, particularly for recurrence. A total of 2,070 patients who underwent total thyroidectomy for classical type PTC with tumor size 1 cm and with available data on preoperative TPOAb and TgAb were enrolled to compare disease-free survival (DFS) according to the presence of preoperative TPOAb, TgAb, and coexistent CLT. Patients with positive preoperative TPOAb had a significantly better DFS compared to patients without positive preoperative TPOAb (hazard ratio (HR) 0.53; 95% confidence interval (CI) 0.30-0.94, p = 0.028) while no difference in DFS was found according to preoperative TgAb status. Positive preoperative TPOAb was an independent prognostic factor for structural persistent/recurrent disease after adjustment for major preoperative risk factors such as age, sex, and tumor size (HR 0.52, 95% CI 0.28-0.99, p = 0.048). Although the coexistence of CLT lowered the risk for structural persistence/recurrence in univariate analysis (HR 0.52, 95% CI 0.31-0.86, p = 0.012), it was not an independent favorable prognostic factor by multivariate analysis (HR 0.65, 95% CI 0.38-1.10, p = 0.106). However, when coexistent CLT was combined with positive preoperative TPOAb, it indicated an independent protective role in structural persistent/recurrent disease (HR 0.39, 95% CI 0.16-0.98, p = 0.045). Our study clearly showed that presence of preoperative TPOAb can be a novel prognostic factor in predicting structural persistence/recurrence of PTC.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The value of preoperative antithyroidperoxidase antibody as a novel predictor of recurrence in papillary thyroid carcinoma

Song

Jeon

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Some reports showed less extrathyroidal invasion [12,22,29,[48][49][50], but others more [7,19,51] in PTCs with thyroid autoimmunity. Similarly, some showed less lymph node metastasis [12,29,36,48,51,52], but others more [16,18,28,53,54].…”

Section: Is Thyroid Autoimmunity Beneficial For or Harmful Against Thmentioning

confidence: 98%

“…Regarding distant metastasis, Shen et al reported more cervical lymph node metastasis but less distant metastasis in anti-Tg-antibody positive group [53], suggesting that the positive anti-Tg antibody status could be a risk factor for metastatic cervical lymph nodes but a protective factor for distant metastasis. Jo et al also concluded that positive anti-Tg antibodies, even without anti-TPO antibodies nor lymphocyte infiltration, are associated with worse primary tumor characteristics (higher rates of lymphatic invasion and lymph node metastasis) but rarely show poor prognosis [54]. They speculated that this might be attributed to more aggressive treatment of these patients.…”

Section: Is Thyroid Autoimmunity Beneficial For or Harmful Against Thmentioning

confidence: 99%

Thyroid Autoimmunity and Thyroid Cancer – The Pathogenic Connection: A 2018 Update

Nagayama

2018

Horm Metab Res

View full text Add to dashboard Cite

The association between thyroid cancer and thyroid autoimmunity has long been suggested, but remains to be elucidated for several decades. Here the data on this issue are updated by summarizing relevant papers published between 2012 and early 2018. Although numerous papers demonstrated the significant increase in the prevalence of thyroid autoimmunity (positive intrathyroidal lymphocyte infiltration and/or anti-thyroglobulin/thyroid peroxidase antibodies) in patients with thyroid cancers as compared to those with benign nodules, and also the significant increase in the prevalence of papillary thyroid cancer (PTC) in patients with thyroid autoimmunity as compared to those without, there are some crucial biases that should be taken into account for their interpretation. However, a difference in the incidence of thyroid autoimmunity in patients with PTCs and those with other types of thyroid cancers appears to support the significant association of two conditions. Thyroid autoimmunity is, at least partly, likely to be elicited against antigens shared by normal and cancerous thyroid tissues, thereby inducing autoimmunity. At the same time, elevated TSH levels (even within the normal reference ranges), which often accompany Hashimoto's patients are a risk factor for thyroid cancer. However, it is still unclear whether or not the co-existence of thyroid autoimmunity impacts on cancer characteristics and prognosis. This issue needs to be further investigated with large-scale prospective studies.

show abstract

“…Vasileiadis et al [ 20 ] reported that DTC patients with TgAb showed more frequent lymph node metastasis than those without TgAb (20.3% vs. 10.0%). Another study also found that elevated preoperative serum TgAb levels in DTC patients were significantly associated with adverse primary tumor characteristics, including nonencapsulated tumors, lymphatic invasion, and lymph node metastasis [ 34 ]. Similarly, Zhang et al [ 35 ] found that DTC patients with TgAb had a significantly higher rate of metastasis of cervical lymph nodes, and that lymph node stage was the only independent indicator for persistent TgAb (OR, 3.183).…”

Section: Preoperative Tgab Levels In Predicting the Prognosis Of Thyrmentioning

confidence: 99%

Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer

Lim

2018

Korean J Intern Med

Self Cite

View full text Add to dashboard Cite

Thyroglobulin antibody (TgAb) is a class G immunoglobulin and a conventional marker for thyroid autoimmunity. From a clinical perspective, TgAb is less useful than thyroid peroxidase antibodies for predicting thyroid dysfunction. However, TgAb is found more frequently in differentiated thyroid cancer (DTC) and can interfere with thyroglobulin (Tg) measurements, which are used to monitor the recurrence or persistence of DTC. Recent studies suggested a small but consistent role for preoperative TgAb in predicting DTC in thyroid nodules, and in reflecting adverse tumor characteristics or prognosis, including lymph node metastasis, but this is still controversial. Postoperative TgAb can serve as a biomarker for remnant thyroid tissue, so follow-up measures of TgAb are useful for predicting cancer recurrence in DTC patients. Since high serum TgAb levels may also affect the fine needle aspiration washout Tg levels from suspicious lymph nodes of DTC patients, it is important to use caution when interpreting the washout Tg levels in patients who are positive for TgAb.

show abstract

Prognostic value of preoperative anti‐thyroglobulin antibody in differentiated thyroid cancer

Abstract: Positive preoperative serum TgAb is associated with worse primary tumour characteristics but rarely showed poor prognosis, probably due to more aggressive treatment of these subjects.

Cited by 22 publications

References 36 publications

The value of preoperative antithyroidperoxidase antibody as a novel predictor of recurrence in papillary thyroid carcinoma

The value of preoperative antithyroidperoxidase antibody as a novel predictor of recurrence in papillary thyroid carcinoma

Thyroid Autoimmunity and Thyroid Cancer – The Pathogenic Connection: A 2018 Update

Clinical implications of anti-thyroglobulin antibody measurement before surgery in thyroid cancer

Contact Info

Product

Resources

About