Prognostic Value of Preoperative Neutrophil-lymphocyte/ Platelet-lymphocyte Ratio in Patients with Stage II-III Rectal Cancer Who Underwent Curative Resection

Mermut, Özlem; İnanç, Berrin; Dursun, Nevra; Trabulus, Didem Can; Yardımcı, Aytül Hande; Arslan, Esra

doi:10.4274/imj.galenos.2020.84553

Cited by 2 publications

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“…Platelets provide angiogenesis, extravasation of cancer cells and survival of cancer cells. 11 When the literature is reviewed, it is seen that neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) calculated from complete blood count are studied in various inflammatory diseases, precancerous lesions and malignancies. [12][13][14] NLR and PLR values were found to be significant in the early diagnosis and prognosis of laryngeal squamous cell carcinoma.…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…Platelets also stimulate tumour growth with various growth factors. Platelets provide angiogenesis, extravasation of cancer cells and survival of cancer cells 11 . When the literature is reviewed, it is seen that neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) calculated from complete blood count are studied in various inflammatory diseases, precancerous lesions and malignancies 12‐14 .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parameters

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Yılmaz²,

Kınış

2021

Int J Clin Pract

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Background:The aim of this study is to compare neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) values, which are inflammatory parameters, in precancerous and cancerous lesions and to determine whether there is a parameter that can be used in the early diagnosis of laryngeal squamous cell carcinoma.Methods: In this retrospective study, 174 patients who were benign as a result of pathology, 122 patients who were malignant, 39 patients who were premalignant (335 patients in total) and 117 normal individuals were included. Data groups were divided into 4 groups as benign laryngeal lesion(BLL), precancerous laryngeal lesion (PLL), malignant laryngeal Lesion (MLL) and control group (CG). In addition, the PLL group was subdivided into mild dysplasia (MiD), Moderate Dysplasia (MoD) and severe dysplasia-carcinoma in situ (SeD/CIS). NLR, PLR and other parameters were calculated.Results: NLR and PLR values were significantly different between the groups.

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Section: Backg Rou N Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parameters

Sizer

Yılmaz²,

Kınış

2021

Int J Clin Pract

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Potential impact of platelet-to-lymphocyte ratio on prognosis in patients with colorectal cancer: A systematic review and meta-analysis

Guo

Gao

et al. 2023

Front. Surg.

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BackgroundNumerous studies have confirmed that inflammation promotes the occurrence, development and prognosis of colorectal cancer (CRC).ObjectiveThis study focuses on the potentially prognostic value of the platelet-to-lymphocyte ratio (PLR) in CRC patients.Data SourcesThis study was registered at PROSPERO (ID: CRD42020219215). Relative studies were searched on PubMed, Cochrane Library, Embase, Web of Science, and clinical trial databases by two back-to-back reviewers. Study Selection and Intervention: Studies were screened according to the predetermined inclusion and exclusion criteria, comparing prognosis differences between low PLR levels and high PLR levels for CRC patients. Main Outcome Measures: Studies were integrated and compared to analyze the value of PLR in predicting overall survival (OS), progression-free survival (PFS), cancer-specific survival (CSS), disease-free survival (DFS) and recurrence-free survival (RFS) of CRC. Results: Outcomes were compared using Review Manager (version 5.4) software from Cochrane Collaboration. A total of 27 literary works, including 13,330 patients, were incorporated into our study. The final results showed that higher PLR levels had worse OS (hazard ratio [HR] = 1.40, 95% confidence interval [CI] = 1.21–1.62, P < 0.00001), DFS (HR = 1.44, 95% CI = 1.09–1.90, P = 0.01) and RFS (HR = 1.48, 95% CI = 1.13–1.94, P = 0.005) than lower PLR levels, respectively. However, there was no evidence of significance for PFS (HR = 1.14, 95% CI = 0.84–1.54, P = 0.40) and CSS (HR = 1.16, 95% CI = 0.88–1.53, P = 0.28) in the final meta-analysis.LimitationsOur study has the following limitations. First of all, we only included literature published in English, which means that some publication bias may be inevitable. In addition, our study used aggregate data, not individual data; furthermore, we did not define the exact cut-off value representing the PLR level.ConclusionAn elevated PLR seems to be an adverse prognostic factor affecting survival outcomes in patients with CRC. Meanwhile, more prospective studies are required to confirm our conclusion.PROSPERO ID: CRD42020219215.

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Prognostic Value of Preoperative Neutrophil-lymphocyte/ Platelet-lymphocyte Ratio in Patients with Stage II-III Rectal Cancer Who Underwent Curative Resection

Cited by 2 publications

References 0 publications

Comparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parameters

Comparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parameters

Potential impact of platelet-to-lymphocyte ratio on prognosis in patients with colorectal cancer: A systematic review and meta-analysis

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