Prognostic Value of Preoperative Peripheral Blood Monocyte Count in Patients with Colorectal Liver Metastasis after Liver Resection

Abstract

Prognostic values of leukocyte subset counts in peripheral blood of cancer patients have not yet been fully investigated. We retrospectively examined the relation between preoperative absolute counts of peripheral blood leukocyte subsets and clinicopathologic factors and long-term prognosis in 97 patients with liver metastasis from colorectal cancer who underwent hepatic resection. Median preoperative peripheral blood leukocyte subset counts were as follows: neutrophils 3148/mm3; lymphocytes 1574/mm3; monocytes 380/mm3. Univariate analysis indicated significantly worse 5-year cancer-related survival for patients with a peripheral blood monocyte count >300/mm3 (67.5%) than for patients with a count <or=300/mm3 (36.8%). Multivariate analysis showed a preoperative peripheral blood monocyte count >300/mm3 and preoperative CEA level (>10 ng/ml) to be independent predictive factors for cancer-related survival after hepatic resection. The preoperative peripheral monocyte count correlated positively with white blood cell and neutrophil counts, but not with the tumor number, interval between colorectal and hepatic surgery, or preoperative serum CEA level. Our findings indicate that a preoperative absolute peripheral blood monocyte count >300/mm3 is an independent predictive factor for cancer-related survival of patients with colorectal liver metastasis who have undergone hepatic resection.

Clinical significance of changes in peripheral lymphocyte count after surgery in early cervical cancer

“…Recently, Schmidt et al reported that pretreatment levels of peripheral neutrophils are independent predictors of overall survival in patients with stage IV Melanoma [23] and this finding was also found in a Japanese study group in advanced non-small-cell lung cancer [24]. In colorectal cancers, peripheral monocyte count is the only independent prognostic biomarker for survival, not neutrophil or lymphocyte counts [25,26]. Because it is unclear whether these conflicting results are due to tumor-specific phenomena or the tumor burden itself (for example advanced vs. early stage), further study is warranted.…”

Prognostic significance of the preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer

“…A correlation between monocytosis and poor prognosis in different types of cancer has previously been observed (16,(25)(26)(27). Monocytes represent a source of chemokines and cytokines that contribute to inflammation (28).…”

A Study of Inflammation-Based Predictors of Tumor Response to Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

“…Some investigators have explored a relation between pretreatment SAL and/or preoperative peripheral ABCC, and prognosis in patients with locally advanced and metastatic CRC [18,23,[28][29][30][31][32][33] . These studies have been based on mixed populations with tumors located in various parts of the large bowel including the rectum.…”