Prognostic Value of Pretherapy Platelet Elevation in Oropharyngeal Cancer Patients Treated With Chemoradiation

Shoultz-Henley, S.; Garden, Adam S.; Mohamed, Abdallah S.R.; Sheu, Tommy; Kroll, Michael H.; Rosenthal, David I.; Gunn, G.B.; Phan, Jack; Lai, Stephen Y.; Kies, M. S.; Gold, Kathryn A.; Fuller, C.D.

doi:10.1016/j.ijrobp.2015.07.1427

Cited by 3 publications

(14 citation statements)

References 33 publications

(40 reference statements)

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“…[34][35][36][37][38][39][40][41][42][43][44][45][46]51 Cohen's kappa for inter-reviewer agreement was 0.75. [37][38][39][40]51 All of the included studies were single-institution studies. The association between platelet count and survival was investigated in 8 studies that involved 4096 patients.…”

Section: Literature Search Resultsmentioning

confidence: 97%

“…We examined titles and abstracts, and excluded duplicate entries, review articles, and articles written in languages other than English from the inception of each database to May 2017. Table 1 [34][35][36][37][38][39][40]51 shows the characteristics of the included studies for platelet count analysis. [34][35][36][37][38][39][40][41][42][43][44][45][46]51 Cohen's kappa for inter-reviewer agreement was 0.75.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…The full texts of the 19 studies selected were then inspected according to exclusion criteria, and, finally, 14 studies that involved 5158 patients were included in the present study. [34][35][36][37][38][39][40]51 and 5 of the 8 studies were published after 2016. Table 1 [34][35][36][37][38][39][40]51 shows the characteristics of the included studies for platelet count analysis.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…Table 1 [34][35][36][37][38][39][40]51 shows the characteristics of the included studies for platelet count analysis. [34][35][36][38][39][40]51 The outcomes analyzed in these studies were OS in 6 studies [34][35][36][37][38]40 and DSS in 3 studies. [34][35][36][37][38][39][40]51 and 5 of the 8 studies were published after 2016.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…On the other hand, the information from blood samples demonstrates only the indirect consequences of cancer progression. [34][35][36][37][38][39][40][41][42][43][44][45][46] Among these studies, only 1 study was prospective. Moreover, blood markers are not affected by any heterogeneity within the tumor.…”

Section: Introductionmentioning

confidence: 99%

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Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

et al. 2018

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Section: Literature Search Resultsmentioning

confidence: 97%

Section: Literature Search Resultsmentioning

confidence: 99%

Section: Literature Search Resultsmentioning

confidence: 99%

Section: Literature Search Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

et al. 2018

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A critical appraisal of the clinical applicability and risk of bias of the predictive models for mortality and recurrence in patients with oropharyngeal cancer: Systematic review

et al. 2019

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The use of predictive models is becoming widespread. However, these models should be developed appropriately (CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modeling Studies [CHARMS] and Prediction model Risk Of Bias ASsessment Tool [PROBAST] statements). Concerning mortality/recurrence in oropharyngeal cancer, we are not aware of any systematic reviews of the predictive models. We carried out a systematic review of the MEDLINE/EMBASE databases of those predictive models. In these models, we analyzed the 11 domains of the CHARMS statement and the risk of bias and applicability, using the PROBAST tool. Six papers were finally included in the systematic review and all of them presented high risk of bias and several limitations in the statistical analysis. The applicability was satisfactory in five out of six studies. None of the models could be considered ready for use in clinical practice.

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A magasabb vérlemezkeszám mint a fej-nyak tumoros betegek túléléssel kapcsolatos esetleges prognosztikai faktora

Szilasi¹,

Jósa

Zrubka

et al. 2021

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Összefoglaló. Bevezetés: Régóta ismert, hogy a daganatokhoz társuló emelkedett vérlemezkeszám rosszabb túléléssel társul. Fej-nyak tumoros betegek esetében kevés információ áll rendelkezésünkre ezzel az összefüggéssel kapcsolatban. Célkitűzés: Vizsgálatunk célja a fej-nyak daganatos betegek prognózisa és a thrombocytosis közötti összefüggés tanulmányozása volt. Módszer: Különféle stádiumú és lokalizációjú, 312, fej-nyak tumoros beteg retrospektív adatait elemeztük. A műtét előtti vérlemezkeszámokat vizsgáltuk, a 300 G/l feletti értéket tekintettük emelkedett thrombocytaszámnak. A vérlemezkeszám és a túlélés közötti kapcsolatot Kaplan–Meier-módszerrel és multivariáns Cox-regresszióval elemeztük. Eredmények: Emelkedett thrombocytaszám mellett szignifikánsan rosszabb túlélést észleltünk (5 éves túlélés: p = 0,007, betegségmentes túlélés: p = 0,192). Ez az összefüggés még akkor is fennállt, amikor multivariáns analízissel nemre, korra, stádiumra, differenciáltsági fokra, lokalizációra, valamint fehér- és vörösvérsejtszámra korrigáltuk az elemzést (5 éves túlélés: p = 0,027). A különféle anatómiai lokalizációkban eltérő mértékben észleltünk 300 G/l feletti vérlemezkeszámot (algarat: 43,6%, sub- és supraglottis: 35,8%, szájüreg: 35,7%, hangszalag: 22,5%, szájgarat: 19%, multiplex: 50%), ez azonban nem befolyásolta szignifikánsan a túlélést (p = 0,603). Következtetés: A daganathoz társuló thrombocytosis összefüggésbe hozható a fej-nyak tumoros betegek rosszabb túlélésével. Az egyes lokalizációkban talált különböző vérlemezkeszámok nem befolyásolják eltérő mértékben a túlélést. Orv Hetil. 2021; 162(17): 676–682. Summary. Introduction: The association between cancer-related thrombocytosis and worse survival has been described with a variety of solid neoplasms. However, only limited data are available on the prognostic significance of elevated platelet count in head and neck tumours. Objective: We aimed to investigate the correlation between the survival of patients with head and neck cancer and thrombocytosis. Method: We conducted an analysis of the data from 312 patients with head and neck squamous cell carcinoma of various stages and locations. Preoperative platelet counts were analysed; elevated platelet count was defined as 300 G/l or higher. The influence of platelet count on survival was calculated with the Kaplan–Meier method as well as with multivariate Cox regression. Results: In patients with excessive thrombocytosis, survival was significantly worse (overall survival: p = 0.007, disease-free survival: p = 0.192). This association remained significant even after adjusting the multivariate analysis for age, gender as well as tumour stage, grade, location, red and white blood cell count (overall survival: p = 0.027). The magnitude of thrombocytosis differed among tumours of different anatomical locations (hypopharynx: 43.6%, sub- and supraglottis: 35.8%, oral cavity: 35.7%, vocal cord: 22.5%, oropharynx: 19%, multiple: 50%), but this did not affect survival significantly (p = 0.603). Conclusion: Elevated platelet count may be related to a worse prognosis in head and neck squamous cell carcinoma patients. The impact of thrombocytosis does not vary with the anatomical location of the tumour. Orv Hetil. 2021; 162(17): 676–682.

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Prognostic Value of Pretherapy Platelet Elevation in Oropharyngeal Cancer Patients Treated With Chemoradiation

Cited by 3 publications

References 33 publications

Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta‐analysis

A critical appraisal of the clinical applicability and risk of bias of the predictive models for mortality and recurrence in patients with oropharyngeal cancer: Systematic review

A magasabb vérlemezkeszám mint a fej-nyak tumoros betegek túléléssel kapcsolatos esetleges prognosztikai faktora

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