Prognostic value of pretreatment volume-based quantitative 18 F-FDG PET/CT parameters in patients with malignant pleural mesothelioma

Kitajima, Kazuhiro; Doi, Hiroshi; Kuribayashi, Kozo; Hashimoto, Masaki; Tsuchitani, Tatsuya; Tanooka, Masao; Fukushima, Kazuhito; Nakano, Takashi; Hasegawa, Seiki; Hirota, Shun

doi:10.1016/j.ejrad.2016.11.019

Cited by 21 publications

(25 citation statements)

References 29 publications

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“…In our study, we found TLG and MTV values as poor prognostic factors in the univariate analysis like reported in the previous study. Additionally, the cut-off values that we found for MTV and TLG were 113 cm³ and 419.5 g/ml*cm³, respectively and these values were reported in the previous study as 39.6-755 cm³ for MTV and 334-2914 g/ml*cm³ for TLG 17,18,20 .…”

Section: Discussionsupporting

confidence: 83%

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The Effect of Metabolic PET Parameters on Survival Outcome in Malignant Pleural Mesothelioma

et al. 2020

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Objective: 18-Fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) is one of the most valuable imaging types and tumor metabolic volume is another parameter that can be obtained from PET-CT. Our primary objective is to evaluate the effect of PET-CT metabolic parameters on survival in patients with malignant pleural mesothelioma (MPM). Methods:A total of 29 patients with MPM had been evaluated with 18F-FDG PET-CT between January 2016 and December 2017. Metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized uptake values (SUVmax) and TLG/liver SUVmean values were calculated. Also, effects of these parameters on survival rates were evaluated.Results: Histological subtypes of the disease were determined as epithelioid (n=24), biphasic (n=3), sarcomatoid (n=2). Median overall survival was 255 days (21-903). Median MTV was 225 cm³ (10-1879), median TLG was 1056 g/ml*cm³ (36-18927), median SUVmax was 7.7 (1.5-20) and TLG/liver SUVmean ratio was 561.2 (14.9-8113.7). Sensitivity and specificity for MTV 113 cut-off value were 86.4% and 85.7%, respectively. Determined cut-off value for TLG was 419.5, sensitivity and specificity of the value were 81.8% and 85.7%, respectively. Additionally, determined cut-off value for TLG/liver SUVmean ratio was 107.4, the rate of sensitivity and specificity for this value were 95.5% and 71.4%, respectively. The patients with higher MTV, TLG and TLG/liver SUVmean had worse survival rate. Conclusion:We confirmed significant association between MTV, TLG and TLG/liver SUVmean values and patients survival. These promising PET derived parameters can be used for evaluating treatment response and prognosis in MPM. ÖzAmaç: 18-Florodeoksiglukoz pozitron emisyon bilgisayarlı tomografi (18F-FDG PET-BT) en değerli görüntüleme yöntemlerinden biridir ve metabolik tümör volümü de PET-BT'den elde edilebilecek başka bir parametredir. Bu çalışmada MPM'de metabolik PET-BT parametrelerinin sağkalım üzerine etkisini değerlendirmeyi amaçladık.Yöntemler: Çalışmaya Ocak 2016 -Aralık 2017 tarihleri arasında tedavi öncesi 18F-FDG PET-BT çekimi yapılan 29 hasta dahil edildi. Tüm hastaların metabolik tümör volümü (MTV), total lezyon glikolizi (TLG), standardize tutulum değerleri (SUVmax) ve total lezyon glikolizi/karaciğer SUVmean (TLG/KC SUVmean) değerleri hesaplandı. Ayrıca bu parametrelerin sağkalım üzerine etkileri değerlendirildi.Bulgular: Histolojik alt tip olarak epitelioid (n=24), bifazik (n=3) ve sarkomatoid (n=2) alt gruplardan oluşmaktaydı. Ortanca sağkalım 255 (21 -903) gün idi. Median MTV değeri 225 cm³ (10-1675), median TLG değeri 1056 g/ml*cm³ (36-1776), median SUVmax değeri 7.7 (1.5-20) ve median TLG/KC SUVmean değeri 561,2 (14.9-8113.7) idi. MTV için cut off değer olarak 113 alındığında sensitivite %86,4 ve spesifite %85,7 idi. TLG için cut off değer olarak 419.5 alındığında sensitivite %81,8 ve spesifite %85,7 idi. Ayrıca TLG/KC SUVmean için cut off değer olarak 107.4 alındığında sensitivite %95,5 ve spesifite %71,4 idi. Yüksek MTV, TLG ve TLG/KC SUV...

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Section: Discussionsupporting

confidence: 83%

“…MTV and TLG are three-dimensional measurements that including total tumor volume and metabolic activity. Therefore, these parameters are more sensitive to the SUVmax value obtained from a single pixel in the assessment of prognosis and treatment response 17 .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Metabolic PET Parameters on Survival Outcome in Malignant Pleural Mesothelioma

et al. 2020

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“…In recent reports, some volume-based quantitative parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) on FDG-PET/computed tomography (CT) have been reported to have material prognostic capability for patients with MPM. [18][19][20][21][22][23][24] Because a morphologic diagnosis based only on imaging is challenging, previous studies have focused on the predictive biomarkers of survival in patients with MPM. For example, the neutrophil-to-lymphocyte ratio (NLR) and the serum lactate dehydrogenase (LDH) level have been reported to be associated with the accurate prognosis of patients with MPM.…”

Section: Introductionmentioning

confidence: 99%

Development of a Novel Prognostic Risk Classification System for Malignant Pleural Mesothelioma

Doi

Kuribayashi

Kitajima

et al. 2020

Clinical Lung Cancer

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“…In addition, MPM in early stage or MPM with a low proliferation rate could have a low FDG uptake (false negative results) while inflammatory disorders such as rheumatoid pleuritic, tuberculous pleurisy and prior pleurodesis could be FDG-avid (false positive results) (1,(24)(25)(26)(27). To overcome these limits, three-dimensional measurements incorporating total tumor volume and metabolic activity may potentially be more sensitive than the SUVmax not only for diagnosis but also for evaluating the response to treatment (28). Figure 2 reports cases of intrathoracic MPM: (I) a MPM case of unilateral intrathoracic spread; (II) a case of MPM with direct tumor invasion to the contralateral pleura.…”

Section: Pet-ct Scanmentioning

confidence: 99%

“…Molecular profiling technologies to assess DNA, RNA, protein and metabolites have led to better understanding of the molecular basis of cancer, with identification of new disease markers (28)(29)(30)(31)(32)(33)(34)(35)(36).…”

Section: Biomarkersmentioning

confidence: 99%

Clinical diagnosis of malignant pleural mesothelioma

et al. 2018

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Prognostic value of pretreatment volume-based quantitative 18 F-FDG PET/CT parameters in patients with malignant pleural mesothelioma

Cited by 21 publications

References 29 publications

The Effect of Metabolic PET Parameters on Survival Outcome in Malignant Pleural Mesothelioma

The Effect of Metabolic PET Parameters on Survival Outcome in Malignant Pleural Mesothelioma

Development of a Novel Prognostic Risk Classification System for Malignant Pleural Mesothelioma

Clinical diagnosis of malignant pleural mesothelioma

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