Prognostic value of prognostic nutritional index score and controlling nutritional status score in patients with glioblastoma: A comprehensive meta-analysis

Abstract

IntroductionSeveral nutritional indicators, including the prognostic nutritional index (PNI) score and the controlling nutritional status (CONUT) score, have been shown to predict the prognosis of patients with glioblastoma. The present meta-analysis was performed to further evaluate the prognostic value of PNI and CONUT scores in patients with glioblastoma.MethodThe PubMed, EMBASE and Web of Science databases were comprehensively searched for studies that evaluated the ability of PNI and CONUT scores to predict the prognosis of patients with glioblastoma. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated by univariate and multivariate analyses.ResultTen articles were included in this meta-analysis, involving 1406 patients with glioblastoma. Univariate analyses showed that a high PNI score was predictive of greater overall survival (OS; HR 0.50; 95% CI, 0.43, 0.58; I2 = 0%) and progression free survival (PFS; HR 0.63; 95% CI, 0.50, 0.79; I2 = 0%), whereas a low CONUT score predictive of longer OS (HR 2.39; 95% CI, 1.77, 3.23; I2 = 25%). Multivariate analyses showed that high PNI score (HR 0.64; 95% CI, 0.49, 0.84; I2 = 24%) and low CONUT score (HR 2.79; 95% CI, 2.01, 3.89; I2 = 39%) were independently associated with longer OS, whereas PNI score was not significantly associated with PFS (HR 1.02; 95% CI, 0.65, 1.59; I2 = 0%).ConclusionPNI scores and CONUT scores have prognostic value in patients with glioblastoma. Additional large-scale studies, however, are required to confirm these results.

Prognostic significance of systemic inflammatory parameters in high-grade glial tumor patients: Two center experience

“…[10] In a thorough meta-analysis, Peng et al showed that PNI and CONUT scores have predictive values in patients with glioblastoma. [11] In a meta-analysis involving 11 studies and 2928 patients with glial tumors, Liu et al found that serum albumin level, AGR, and PNI have predictive significance. [12] In contrast to these promising investigations, Lopes et al’s [13] analysis of 139 GBM patients failed to demonstrate an association between a higher NRL and worse prognosis.…”

“…The median tumor size was 5 cm. [2][3][4][5][6][7][8][9][10][11] Edema and shift were both present at the time of diagnosis in 52 (65.8%) and 33 (41.8%) individuals, respectively. The patient and tumor characteristics are shown in Table 1.…”

Prognostic and clinicopathological significance of the Controlling Nutritional Status (CONUT) score in patients with lymphoma: a meta-analysis

“…Recently, numerous meta-analyses have been conducted to explore whether CONUT scores can be used to predict the prognosis of various tumour types 43–45. Peng et al 43 showed that CONUT scores have a prognostic value for OS in patients with glioblastoma in their meta-analysis of 1406 cases.…”

“…Recently, numerous meta-analyses have been conducted to explore whether CONUT scores can be used to predict the prognosis of various tumour types. [43][44][45] Peng et al 43 showed that CONUT scores have a prognostic value for OS in patients with glioblastoma in their meta-analysis of 1406 cases. Xue et al 44 reported that a high CONUT score predicted dismal OS, cancer-specific survival (CSS) and recurrence-free survival (RFS) in upper tract urothelial carcinoma and renal cell carcinoma in their meta-analysis of 5410 cases.…”

Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

“…Here again, large and well-designed studies are necessary [156]. A recent meta-analysis reported that several nutritional indicators, including the prognostic nutritional index (PNI) score and the control nutritional status (CONUT) score, as well as the assessment of sarcopenia, may contribute to the prognosis of HGG patients [157,158].…”