Prognostic Value of Proliferation, Apoptosis, Defective DNA Mismatch Repair, and p53 Overexpression in Patients With Resected Dukes' B2 or C Colon Cancer

Garrity, Megan M; Burgart, Lawrence J.; Mahoney, Michelle R.; Windschitl, Harold E.; Salim, Muhammad; Wiesenfeld, Martin; Krook, James E.; Michalak, John C.; Goldberg, Richard M.; O’Connell, Michael J.; Furth, Alfred; Sargent, Daniel J.; Murphy, Linda; Hill, Eunice M.; Riehle, Darren; Meyers, Cecelia H.; Witzig, Thomas E.

doi:10.1200/jco.2004.10.042

Cited by 119 publications

(89 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the prognostic role of the Ki-67-labelling index in colorectal carcinoma is still highly controversial and probably different from other solid neoplasms. In fact, recent observations document that a high Ki-67-labelling index is associated with better OS (Allegra et al, 2003) in both treated and untreated patients (Garrity et al, 2004), as reported in the current series (Table 2).…”

Section: >100supporting

confidence: 82%

Independent prognostic value of fascin immunoreactivity in stage III–IV colonic adenocarcinoma

et al. 2007

View full text Add to dashboard Cite

Fascin, an actin-bundling protein involved in cell motility, has been shown to be upregulated in several types of carcinomas. In this study, we investigated the expression of fascin in 228 advanced colonic adenocarcinoma patients with a long follow-up. Fascin expression was compared with several clinicopathologic parameters and survival. Overall, fascin immunoreactivity was detected in 162 (71%) tumours with a prevalence for right-sided tumours (Po0.001). Fascin correlated significantly with sex, tumour grade and stage, mucinous differentiation, number of metastatic lymph nodes, extranodal tumour extension, and the occurrence of distant metastases. Patients with fascin-expressing tumours experienced a shorter disease-free and overall survival in comparison with those with negative tumours, and fascin immunoreactivity emerged as an independent prognostic factor in the multivariate analysis. Moreover, patients with the same tumour stages could be stratified in different risk categories for relapse and progression according to fascin expression. Our findings suggest that fascin is a useful prognostic marker for colonic adenocarcinomas.

show abstract

Section: >100supporting

confidence: 82%

Independent prognostic value of fascin immunoreactivity in stage III–IV colonic adenocarcinoma

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Regarding Ki-67, studies have shown that its immunohistochemical expression is not correlated with survival (12) . However, in contrast, Garrity et al (9) reported that this marker was significantly associated with increased survival.…”

Section: Discussionmentioning

confidence: 90%

“…This finding is in agreement with the results presented by Kim et al (16) , in a study on 542 patients. On the other hand, despite similar data for p53 and bcl-2, Garrity et al (9) presented a different result for Ki-67 and concluded that the latter marker was strongly associated with longer disease-free intervals.…”

Section: Discussionmentioning

confidence: 92%

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Menezes

Júca

Gomes

et al. 2010

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -Search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancer -Objective -To analyze the immunoexpression of the proteins p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors. Method -Tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissue resected from 82 patients who had undergone surgery but not chemotherapy or radiotherapy, at "Hospital São Paulo", São Paulo, SP, Brazil, between 2002 and 2005. Thin sections (4 μm) were subjected to immunohistochemical reactions, and immunoexpression staining scores were obtained. The scores were correlated with the degree of cell differentiation, staging, disease-free interval, recurrence, survival and specific mortality. The study variables were analyzed using the chi-square and Kaplan-Meier tests to investigate associations with the markers. The significance of the differences between the curves of the diseasefree interval and survival was analyzed using the Logrank and Wilcoxon tests. Results -The immunohistochemical expression of p53 was positive in 70 tumors (85.4%) and negative in 12 (14.6%). The expression of bcl-2 was positive in 26 (31.7%) and negative in 56 (68.3%). The expression of Ki-67 was positive in 62 (75.6%) and negative in 20 (24.4%). There was no statistically significant correlation between the expressions of these markers separately or in conjunction, in relation to the degree of cell differentiation, staging, disease-free interval, survival and specific mortality. In relation to recurrence, there was a statistically significant correlation with positive expression of Ki-67 (P = 0.035). Conclusion -The immunohistochemical expression of Ki-67 in colorectal cancer is associated with recurrence of this disease. HEADINGS -Colorectal neoplasms. Adenocarcinoma. Immunohistochemistry. Tumor suppressor protein p53. Proto-oncogene proteins c-bcl-2. Bcl-2 homologous antagonist-killer protein.

show abstract

“…Of particular interest, there was no association with any other clinicopathological characteristic, and in a multivariate analysis, MICA was shown along side tumor stage and extramural vascular invasion to be an independent marker of prognosis. Although markers of growth, apoptosis and tumor suppressor gene products have been shown to be associated with disease progression, [21][22][23][24] this is the first time that a molecule involved in immune recognition of tumors has been shown to be an independent marker of good prognosis in colorectal cancer patients. Of particular interest is the strong association between MICA expression and survival in TNM stage III patients.…”

Section: Discussionmentioning

confidence: 99%

Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients

Watson¹,

Spendlove²,

Madjd³

et al. 2005

Int. J. Cancer

133

View full text Add to dashboard Cite

The realization of targeted cancer therapy has driven the need to improve selection of patients with colorectal cancer for adjuvant therapy, leading to a search for potential new prognostic markers. There is accumulating evidence that immunosurveillance acts as an extrinsic tumor suppressor. As genetic instability is an early event in colorectal cancer, this can lead to altered expression of molecules conferring resistance to immune attack. Hence, molecules up or downregulated in this process may impact on patient survival. In our study, 449 colorectal tumors were screened for expression of the stress-related protein MICA, which functions as a ligand for the NKG2D receptor and whose expression confers susceptibility to both T-and NK-cell attack. Intensity of MICA expression was quantified using automated image analysis and MICA expression showed no correlation with conventional clinicopathological variables. In contrast, survival analysis showed a significant correlation between higher levels of MICA expression and improved disease-specific survival, with independent prognostic significance in multivariate analysis. Thus, patients with low levels of MICA and a poor prognosis may be good candidates for aggressive chemotherapy. In contrast, patients with high expression of MICA may be candidates for the antibody therapies, as they should be susceptible to NK killing by antibody dependent cellular cytotoxicity. ' 2005 Wiley-Liss, Inc.

show abstract

Prognostic Value of Proliferation, Apoptosis, Defective DNA Mismatch Repair, and p53 Overexpression in Patients With Resected Dukes' B2 or C Colon Cancer

Cited by 119 publications

References 56 publications

Independent prognostic value of fascin immunoreactivity in stage III–IV colonic adenocarcinoma

Independent prognostic value of fascin immunoreactivity in stage III–IV colonic adenocarcinoma

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients

Contact Info

Product

Resources

About