Prognostic Value of PTENP1 Expression in Patients with Cancer: a Systematic Review and Meta-Analysis

Dai, Caili; Sheng, Xianneng; Wang, Jinqiu; Yong-ping, Dai; Kuang, Yuting; Xu, Zhao‐Dong; Yu, Xiao‐Qi

doi:10.7754/clin.lab.2021.210328

Cited by 2 publications

(3 citation statements)

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“…In addition, we found that PER3P1 possesses an excellent diagnostic capacity for distinguishing between T2D (AUC=0.79) and CRC patients (AUC=0.81). Several pseudogenes (double homeobox A pseudogene 10 (DUXAP10) and phosphatase and tensin homolog (PTENP) 1) have been introduced as diagnostic and prognostic biomarkers in various cancers [28][29][30]. A recent meta-analysis study emphasized the importance of PER1/2/3 genes as potential biomarkers in cancer prognosis.…”

Section: Discussionmentioning

confidence: 99%

Dysregulation of PER3 clock gene and its only pseudogene in colorectal cancer and type 2 diabetes

Najari-Hanjani

Najafi

Akbar

2022

ARCH BIOL SCI BELGRA

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The period (PER) family genes (PER1, PER2, and PER3) play a fundamental role in regulating the day/night cycle. PER3 has a pseudogene variant, PER3P1 or PER4, whose role and expression pattern is unclear in human health and diseases. This study was performed to evaluate the expression levels of normal PER family members and the PER3P1 pseudogene in colorectal cancer (CRC) and type 2 diabetes (T2D). Blood samples were taken from 50 diabetic patients and analyzed using real-time PCR for quantification of PER3 and PER3P1 expression. Colorectal tumor tissues of 50 individuals were also used to evaluate the expression of PER members. All PER members, including PER3P1, were found to be downregulated in colorectal tumor samples. Blood samples collected from diabetic subjects revealed an opposite expression pattern; both PER3 and its pseudogene were found to be upregulated when compared to the control group. Our results reveal coordination between the expression pattern of PER3P1 and normal PER family genes. Based on our findings and the pathological importance of this pseudogene, it can be suggested that PER3P1 may be one of the key regulators of the molecular clock network and PER family expression. This hypothesis needs to be confirmed by further studies.

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Section: Discussionmentioning

confidence: 99%

Dysregulation of PER3 clock gene and its only pseudogene in colorectal cancer and type 2 diabetes

Najari-Hanjani

Najafi

Akbar

2022

ARCH BIOL SCI BELGRA

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“…In head and neck squamous cell carcinoma cell lines, complete and partial losses of PTENP1 are known to be frequent; however, the deletion of genomic PTEN is not common, further providing evidence for PTENP1 being under selective pressure to undergo copy number loss in cancer [149]. Furthermore, in studies showing lower levels of PTENP1 in cancer, it has been predicted to be a promising candidate as a future prognostic biomarker [150].…”

Section: Expression Of Pten and Ptenp1 In Cancermentioning

confidence: 99%

“…A systematic review and meta-analysis of the data from the literature has recently been published revealing the prognostic value of PTENP1 expression in cancer. Dai et al indicate that low expression of PTENP1 might predict poor prognosis for various carcinomas [150].…”

Section: Ptenp1 Also Functions Independently Of the Pten Cerna Networkmentioning

confidence: 99%

PTEN, PTENP1, microRNAs, and ceRNA Networks: Precision Targeting in Cancer Therapeutics

Travis,

McGowan,

Simpson

et al. 2023

Cancers

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The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a well characterised tumour suppressor, playing a critical role in the maintenance of fundamental cellular processes including cell proliferation, migration, metabolism, and survival. Subtle decreases in cellular levels of PTEN result in the development and progression of cancer, hence there is tight regulation of the expression, activity, and cellular half-life of PTEN at the transcriptional, post-transcriptional, and post-translational levels. PTENP1, the processed pseudogene of PTEN, is an important transcriptional and post-transcriptional regulator of PTEN. PTENP1 expression produces sense and antisense transcripts modulating PTEN expression, in conjunction with miRNAs. Due to the high sequence similarity between PTEN and the PTENP1 sense transcript, the transcripts possess common miRNA binding sites with the potential for PTENP1 to compete for the binding, or ‘sponging’, of miRNAs that would otherwise target the PTEN transcript. PTENP1 therefore acts as a competitive endogenous RNA (ceRNA), competing with PTEN for the binding of specific miRNAs to alter the abundance of PTEN. Transcription from the antisense strand produces two functionally independent isoforms (PTENP1-AS-α and PTENP1-AS-β), which can regulate PTEN transcription. In this review, we provide an overview of the post-transcriptional regulation of PTEN through interaction with its pseudogene, the cellular miRNA milieu and operation of the ceRNA network. Furthermore, its importance in maintaining cellular integrity and how disruption of this PTEN–miRNA–PTENP1 axis may lead to cancer but also provide novel therapeutic opportunities, is discussed. Precision targeting of PTENP1-miRNA mediated regulation of PTEN may present as a viable alternative therapy.

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Prognostic Value of PTENP1 Expression in Patients with Cancer: a Systematic Review and Meta-Analysis

Cited by 2 publications

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Dysregulation of PER3 clock gene and its only pseudogene in colorectal cancer and type 2 diabetes

Dysregulation of PER3 clock gene and its only pseudogene in colorectal cancer and type 2 diabetes

PTEN, PTENP1, microRNAs, and ceRNA Networks: Precision Targeting in Cancer Therapeutics

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